6YLE


Conserved Protein Domain Family
RIX1
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pfam08167: RIX1 
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rRNA processing/ribosome biogenesis
Rix1 is a nucleoplasmic particle involved in rRNA processing/ribosome assembly. It associates with two other proteins, Ipi1 and Ipi3, to form the RIX1 complex that allows Rea1 - the AAA ATPase - to associate with the 60S ribosomal subunit. More than 170 assembly factors are involved in the construction and maturation of yeast ribosomes, and after these factors have completed their function they need to be released from the pre-ribosomes. Rea1 induces the release of the assembly protein complex in a mechanical fashion. This family is usually associated with NUC202, pfam08166.
Links
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Statistics
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PSSM-Id: 429855
Aligned: 89 rows
Threshold Bit Score: 84.9244
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6YLE_C                  8 VSTLARNLEIA---KGNEFHTILATLRSPVYINEQLLKSELSF-------LVTKILKLIRSGNDFDLWKGCHTSVVTCA- 76  
CCF54055               31 LDLLLSLIPSAs-sDPAQEDDILAIISQSGLLAHVPQDETQHK-------LTVRINSLISSQN----ALGYRLAHLWIQq 98  
EIE86195                3 ETLINFYLSKEa-vLIKNLPFVLDAIVNHGLFSESSELSEEsasl--hkkWTVRLNSLLQSKVSTVRWCGITLVRATCE- 78  
EPB91697               16 SSVISLYMSNDn-lIHQNLSFILDIIVNHRLFHEPSNEEPNDElaavyrkWTVRLNALLQSKNAAARWCGITLVKTTCE- 93  
ELU38380                9 ELVLQNHLGTDe-sAIKYLPNVLTVLQQPGILQETRvl----------gkWNARINSFLHSREVASRWVGLYIARYTAL- 76  
XP_007391825            7 KILLQLHLASDt-hAVLHLPYVLTTLNAEALQPSAHTQK-----------WITRIYSLLHSKDASVRWAGLCIALRTSV- 73  
EGO02144                8 KSLLQLQLVSDp-sTVLNISYVLTHLTQEYFIPSPHLQK-----------WTTRITSMLHSKDPGARWAALCLAHKTSL- 74  
WGS:AAWC:PGTG_16304.3  11 EYLLNTYLANDqqlSDQIANSICSTFDQTTAITTPAETTTTTEin----rWFNRINSLLISKNESLNSLGARLARLTLQ- 85  
EIM21774                7 KLVLRNYLSSP---DDKSGATALQLLQTDSQALDLSGSFEll------sqLNTRVLTLIQSRNQYERSLGLQIAILWVNe 77  
EOQ99490               13 KLVLRNYLSNP---EEKPALAALQLLESDASVFNPDESSEml------tqLNTRINTLQQSRDQFERSLGFQLAVVWANa 83  

6YLE_C                 77 --YNP-LVLSTHGGQLLAAIYSRLEQKtg----fySS--VISsshgkqlFNTLIS-SVAIIID-LMKNKPTLSREALVPK 145 
CCF54055               99 daAIWhDHLATSASTWATQIVNLLSAPeklltqreHS--DCL-------LASALQlAVTHLFPeGITARQEFYRQVVHPN 169 
EIE86195               79 --SSH-SLLVANAKTWCAQLLAFIAKN--------EA--DMI-------HKEALE-TLQFIFT-YTHDKPELHREVATPN 136 
EPB91697               94 --NSH-HLLVANAKTWSAQLLGFVGKTa-------EP--VAI-------HQECIE-TLSFLFS-YTIDKPELQREVATPN 152 
ELU38380               77 --GSR-QILIDNAQGWVGVVLPMLSKP--------ES--PPN-------HYSAIR-LLSYIFT-AVTDMPEFQRQVVVPN 134 
XP_007391825           74 --NSR-PVMIKCAQSWITATLPVLLKN--------EA--PAA-------LKATIR-LLRFIFA-EAVNYPEFQRQVATPN 131 
EGO02144               75 --LSK-FTMVECSQTWLGVALPLLSKN--------EP--LPI-------LKASIR-FLHHVFS-ATTDVPEFQRQVVTPN 132 
WGS:AAWC:PGTG_16304.3  86 --KDP-DCLTNQGARWIQASQNIIARH--------QPvdHIC-------LSHQIH-LILNIFE-WATRWPDFARENCDPK 145 
EIM21774               78 rvSSL-DCIRQFGKQWIEKALAIVNRAn-------DE--KAT-------MKLALE-LTTVIFS-SATRLPEFSRNVTQPL 138 
EOQ99490               84 rvSSL-DCIRQYGKQWLEKAIAVVNRGn-------EE--AAT-------LKHALT-LTTLIFT-AATRLPEFGRAVTQPL 144 

6YLE_C                146 -LKAIIPTLITLSQYE---------------PELVLPVLQRILKRNTTTFKPFTNKFRTVLIN-LIISDYASL 201 
CCF54055              170 -LPKFAVGLTQLLENIvskqdaegvtafgthLRTVLVFLNRLLHAHSAQFRPVSSRIHECISS-LLYRDDALS 240 
EIE86195              137 -MQRFNQLLLQLAQke-------------ilLPSVLSALAANNAHFPSNSKHIAEQTLQLCLS-CLDGSRDLD 194 
EPB91697              153 -LQRYNQLLLQLGRkq-------------elLATVLSALTANVKCFPSTARHISDQCLQLCLS-CLDGSRDLD 210 
ELU38380              135 -VQKCSQALLAIAKnses---------eldlKLLAIDTLTKLTTYHPTHHKALHQQLLNFTLE-HLQGSFPVP 196 
XP_007391825          132 -VPKLSLALVPLAEktdn----------eevQVLVLETLTHLVPLYPTLHRALLQSLSNLALR-FLNGSAPRP 192 
EGO02144              133 -IPKFSLALISLAEkqhd----------lelKTLVLDTIASLVPLHPTSHRGVTSALNAMCLR-LLNGSAPQP 193 
WGS:AAWC:PGTG_16304.3 146 aIITLARSLIAISEDRied---------pkiRSLGLRTLAILITRYASIMRPLASQLQTLALTnILNPEKIIS 209 
EIM21774              139 -AVKYAQKLLDILKHRsd------------lQIDAINAISDHLTTHSSSFRPQLNALNAQVVA-LLAKSPDNA 197 
EOQ99490              145 -SVKYAQRLVDLVKQRrd------------vQIDAMHAASDHLITHPSSFRPQLNALNGVVTE-LLAHSPDST 203
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