Conserved Protein Domain Family
PDDEXK_6
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pfam04720: PDDEXK_6 
PDDEXK-like family of unknown function
PDDEXK_6 is a family of plant proteins that are distant homologs of the PD-(D/E)XK nuclease superfamily. The core structure is retained, as alpha-beta-beta-beta-alpha-beta. It retains the characteriztic PDDEXK motifs II and III in modified forms - xDxxx motif located in the second core beta-strand, where x is any hydrophobic residue, and a D/E)X(D/N/S/C/G) pattern. The missing positively charged residue in motif III is possibly replaced by a conserved arginine in motif IV located in the proceeding alpha-helix. The family is not in general fused with any other domains, so its function cannot be predicted.
Links
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Statistics
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PSSM-Id: 428087
Aligned: 88 rows
Threshold Bit Score: 182.011
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003529329  31 VEFEFLDDGeimsLAKsEGSgdefhqsneMELDDEDDGervDGGSVEENRS-----FWDNQHQLLQTN--------LYRT 97 
XP_003564912  42 LVQAFLETEnsaaLEE---------------DHPAPKGsgaADDDGSSASA-----AAAAAAAAMRELld-----pPAAE 96 
BAS80642      52 LVHEFYDDGergaDATa--------------R----------GGVSSSPEP-----EPTEWKDALREAl------aDATS 96 
O48807        41 LVASFIEKEgqivLRE--------------------------EEETSSDDN-----NLEDVNERLRKLl------eGLSC 83  thale cress
CDY53353      45 LIESFIDREvkvlSGEvPPG---------EEN----------DDKSDADDD-----DDEDVKERLREIl------eNHGG 94 
XP_004250255  45 LVNSFLEGEvitvNEKlEEIdgn---vetNCF------------------------DESEIKENLRNLld----pdGNSG 93 
EEF43787      42 LVNSFIERDdhptILFmESD---------IKI----------NHPPDDDNQehysvSDAENKNILESLl------nKEDD 96 
XP_006586767  67 LVKSFMEKNetttTGEkEEEeee----ggGVH----------EEELEKTEW-----SDSEKREMLQSFlygkedetDEDE 127
KRH11519      43 LVKSFMEKNeattGEKeEEEvgd---vreGHD----------EEEFEKTEW-----SYSEKREMLRSLlye--nddDEDE 102
XP_002271985  40 LVDSFLERDvielQVGdEDG---------KME----------EERSDFDSEnr--wSDSLTREMLQSLisgd-dgnDDGD 97 

XP_003529329  98 TSVESRIRNVTKEAVQDiQnAEivcscsrqiisRscrNCFMiQVSRRLQKSGYDSAICKTKWSSS-PSIPSGEHTFLDVI 176
XP_003564912  97 DPFRIRLAAAVSAALEA-EgSHg----------HvhgAALRrAMVRRLRAAGYDAGVCKSRWEASgGGLTAGAHEYVDVV 165
BAS80642      97 DAAAARIRAEAERAVRD-AvRNg-------------gDVIRkRVVERLRARGFDAGVCRSSWERT-GSVPAGSHEYVDVT 161
O48807        84 GEERMRILSATMEVAGT-FvGDi--------------SSSKrHLMAFLRNKGFDAGLCKSSWERF-GKNTGGKYEYVDVR 147 thale cress
CDY53353      95 GGERRRIIDEVVNASEL-VgE-------------------KrYLMAYLRKKGFDAGLCKSRWERF-GKNTAGKYEYVDVN 153
XP_004250255  94 DDLKKNVINAVENALLAe---------------EassPEFKrWLMTRLRDQGFDAGLCKLKWEKA-VNRTSGSYEYIDVN 157
EEF43787      97 DDVRKKIRSETEIACGI-IgERs-------------sHGFHrSLMSHLRHLGFDAGLCKSRWEKF-GRYPAGEYQYVDVN 161
XP_006586767 128 RDAKEKIRREVEVAFGL-VgNN-----------------YKrRLISLLREKGFDAGLCKSKWEKN-GRLTAGDYEYIDVN 188
KRH11519     103 RDDKEKIRREAEVAFGV-VvGN----------------YSKrRLMSLLREKGFDAGLCKSKWEKN-GRLTAGDYEYIDVN 164
XP_002271985  98 DDVKRKIRDELEVKCRS-Le-------------NcqaEGFKrRLMTLLRRRGFDAGLCKSRWEKT-GRCPGGEYEYIDVV 162

XP_003529329 177 Dsrsk-kqeiRVIIELNFRAEFEMARASEEYNGLVRKLPE-VYVGKIERLSNIIKVLCMGAKRCMKENKMHMGPWRKHKY 254
XP_003564912 166 Fspsa-apstRYIVDPEFRAGMEVARATAEYAAVVAAVPSpAVVAREESLGRAVRVAADAARRSLRAQGLHVPPWRKSRY 244
BAS80642     162 AaasatgrraRYIVEVNVAGEFEIARPSAEYQDLLLSLPP-VLVATPEAFRGVAAAMCAAAAESIRGAGMHLPPWRRARY 240
O48807       148 Cggd---ynnRYFVETNLAGEFEIARPTKRYLSILSQVPR-VFVGTSEELKLLVRIMCHEMRRSMKHVGIHVPPWRRNGY 223 thale cress
CDY53353     154 Egd-----knRFIVETNLAGEFEIARPTTRYISLLSQLPR-VFVGTPEELKQLVRIMSFEVRRSMKRAEIHVPPWRRNGY 227
XP_004250255 158 Igv------tRYIIEVSLVEEFEIARATPCYTSLLENFPH-VFVGKVEELKQVVRIMSRAMKRSMKKMNIYVAPWRRLAY 230
EEF43787     162 Vgg------nRLIVEVCLAAEFEIARPTLNYTALVDDFPP-VFIGKPEEMKQVVRLMCSAIRESMKEMKLHVPPWRKIGY 234
XP_006586767 189 Fkg------kRYIVEISLAGEFEIARPTDQYSSLLDVFPL-IFVGKVEEMKQVVRLMCTAIKGSMKRMKLHIPPWRRNVY 261
KRH11519     165 Fkg------kRYIVEVSLAGKFEIARPTDQYSSLLDVFPL-IFVGKVEEMKQVARLMCTALKGSMKRMNLHIPPWRRNMY 237
XP_002271985 163 Vae------sRYVVEVFLAGEFTIARPTSYYQTLLRLFPC-VMVVKQFELKQMVRLMCAEMKKSMKIRDMPVPPWRKNGY 235

XP_003529329 255 VHAKWLGPCKR 265
XP_003564912 245 MLAKWLGPYKR 255
BAS80642     241 VQAKWSAPYER 251
O48807       224 MQAKWFGFYKR 234 thale cress
CDY53353     228 MQAKWFGHYKR 238
XP_004250255 231 MEAKWFGSYKR 241
EEF43787     235 MQAKWFAPYKR 245
XP_006586767 262 MQAKWFGAYKR 272
KRH11519     238 MQAKWFSAYKR 248
XP_002271985 236 MQAKWFGPYKR 246
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