Conserved Protein Domain Family
HMG-box_AtHMGB1-like
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cd22005: HMG-box_AtHMGB1-like 
high mobility group (HMG)-box found in Arabidopsis thaliana high mobility group B protein 1 (HMGB1) and similar proteins
This subfamily contains a group of Arabidopsis thaliana HMGB family proteins, including HMGB1, 2, 3, 4, 5, 7, 12 and 14. They bind preferentially to double-stranded DNA. HMGB1 modulates general plant growth and stress tolerance and confers sensitivity to salt and genotoxic (methyl methanesulfonate, MMS) stresses. HMGB2 and HMGB5 confer sensitivity to salt and drought stresses. HMGB7 is required for karyogamy during female gametophyte development, when the two polar nuclei fuse to form the diploid central cell nucleus. Members of this subfamily contain only one HMG-box domain.
Links
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Statistics
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PSSM-Id: 438821
Aligned: 28 rows
Threshold Bit Score: 64.6372
Created: 19-Jun-2020
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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putative DNA
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        ## #####  ##      #            ##  #  ##      #   #  #   #  #
O49595        54 KRAPSAFFVFLEDFRVTFKKenpnvkavsAVGKAGGQKWKSMSQaEKAPYEEKAAKRKAEY 114 thale cress
Q8LDF9       116 KRPLTAFFIFMSDFRKTFKSehng-slakDAAKIGGEKWKSLTEeEKKVYLDKAAELKAEY 175 thale cress
Q941D1        64 TTSLTDFAVFMNHFRKSFRTdyng-alvkEGSKIGWEMWKSMTEdEKKDYLDKAADEEDED 123 thale cress
RWS06074     174 KRPGTAFMLFMADFRKEMAGkepe-ggvaALAKLGGERWRNMSEeEKRPYVEKQNEEKLRY 233 Dinothrombium tinctorium
AAN31640     101 KRPPTAYFLFLADYRIRMANkgi---ehkELLKMAGEEWRSLSNeDKKPYEKKALEESKKY 158 bloodfluke planorb
ELU12309     100 KRPQSAYFLWLAGFRTRMKDkip---vnkELLRAAGEHWKRLTEvEKAPYEQMAEGERRKY 157 Capitella teleta
NP_001072036 268 KRPPSAYFLFLADFRKNYPGksd---pakEITKKAGEAWNSLSDaEKTPYYRSAQLVRAKW 325 vase tunicate
XP_013415987 109 KRPQSGYFLFLGDFRTKMKGkdl---ghkAIIQEAGKAWNAMDAeAKRPYEEEAQKKRDEY 166 Lingula anatina
XP_030516074  34 TRPGLDFRIFMKDFRESYRAef-----dsAVAKAGAEAWDSMSEaEKHPYAEKALELTDFF 89  Rhodamnia argentea
KHN76541      56 KKPHTAYVLFLATQKRSQTKgndt--sfsEHMSIIGRRWNALSDeQKRPFLEKAEAERVEY 114 dog roundworm

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