Conserved Protein Domain Family
SGT1

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pfam07093: SGT1 
SGT1 protein
This family consists of several eukaryotic SGT1 proteins. Human SGT1 or hSGT1 is known to suppress GCR2 and is highly expressed in the muscle and heart. The function of this family is unknown although it has been speculated that SGT1 may be functionally analogous to the Gcr2p protein of Saccharomyces cerevisiae which is known to be a regulatory factor of glycolytic gene expression.
Statistics
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PSSM-Id: 462089
Aligned: 28 rows
Threshold Bit Score: 726.749
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDV96819      18 VEYYIFPK--LSDGGDEEQVRQQLELVRVECLAIVEKKISDrcYIWHKDEFQLLTRTGSaeecllneednnkqeeeetet 95 
XP_001947588  16 VEYFLFVRs-DDSEEDAEELVKHINNLNTKALELVDRLSEQ--YIWHKDKFNLIPRFCPsaelrqs---------fsdts 83 
4_pfamImport   1 VEYFIFSD------HDKDNPLEFYGRLGQQVENAVKESSKD--YIWQKDEFHVISRNVNdlppi-------------idn 59 
XP_967648     17 VEYHLFPP---IDSQDDKEQELALTRVLNQCEKIVKRYTDE--YLWHKDEFKLTVRTWIsnslih-----------dsek 80 
XP_001955876  18 VEYYIFPRl-PDNLREPTKLHQQMVEVHKDINAIVKEKTLErsYLWHKDEFKLQIRTGSpeerllnee----tnpeeetn 92 
NP_001071738  13 THYTLYAN--------KLSDCNKLEEILLKCQAIVAKETHG--HIWQNEPFQLSICK----------------------- 59 
Q949K3        23 VFFSIYPDftLNPTSPPTSITSQLQSLHLQILQNLSPFTSN--YIWQHEPFTLTLSP----------------------- 77  tomato
KRH39459      19 VFYAIYPD------SPTTTSTATLRSLHLKILETLSPFTED--YIWQHQPFTLSVSTPPnpscp-------------cps 77 
XP_006381540  19 VYYAIFPD--SSSLSNPSASSQSLH-LYLQILDFISPYTSS--YIWQHEPFSLSLSSSS--------------------- 72 
Q9LSM5        22 VFFSLFPD--------SSLSSAALQSLHLEIIDFVSPFTSP--YIWQHEPFSLSIALSSsca-----------------c 74  thale cress
EDV96819      96 yGALPPHLHGVTHYGDNIGDEWFIVYLLGELTRSRPDCIVRVSDADGEFLLIEAADVLPDWASPETCEQRVYIVNGGLQL 175
XP_001947588  84 dEVLPPHLYGVTHYGDNIEDEWFIVFLMKEITKEYPELVARVIDSDGEFLLIEAAECLPNWANPDNCDQRVYISDGDVHI 163
4_pfamImport  60 eERLPPHLYGVTHYGENIEDEWFIVYLLIQLTKNIPGLIARVVDTDGEFLLIEAADFLPKWASPEVCEKRVYIFDGEVHI 139
XP_967648     81 tEYLPPHLYGVTHFGDNIEDEWFIVFLLRLLTKEIDGLIARVHDADGEFILIEAADYLPLWADPNNCENRVYIYQGNIHI 160
XP_001955876  93 mGDLPPHFHGVTHYGDNIADEWFVVYLLTEITRARGDCIARVCDSDGEFLLIEAAEALPDWASPESCERRVYIVNGGLQL 172
NP_001071738  60 -TTTPFSLKGNTNYGDSVDDEWFIVYLLHKITISLTQLVATINDSDGEFLLIEAAEYLPKWLTPTTCNNRVFISKGLVHI 138
Q949K3        78 -GPTPPHLSGKLRYGDNLEDEWFVVFLLFETSKRFPSVSIRVWDSDGEFLLIETAFYLPRWVNPDTAMNRVFIRGGFLHI 156 tomato
KRH39459      78 sSSHLLHLHGRLRFGDNLDDEWFAVFLLFRISQRFPSLSIRIWDSDGDFLLIEAAFHLPRWLNPDTAHHRLFLRNGSLHI 157
XP_006381540  73 -SPPLPHLHGKLRFGDNIEDEWFTVFLLFQISHHFPSLSIRVWDNDGEFLLIEAAFHLPRWINPETSDNRVFIRRGDIHI 151
Q9LSM5        75 tNTAIPHLHGKLKYGDNLEDEWFAVFLLFRISAAFPSNSIRVWDTDGEFLLIEAAFHLPRWLNPETSLNRVFIRGGDLHI 154 thale cress
EDV96819     176 VQNSATTSE---SESKRMPISSAVQRIRLNPTLFRCSRDIQNCIDSRLQEFlAAKPHASIHRQIVQLPQNAAQLLKQRPG 252
XP_001947588 164 IPLVSANSK------KSITVSQALEQITKYPTATIATQEVNSAISSRLHGY-PDKIKENLHCCHAYIPVGVAYLLKHQPS 236
4_pfamImport 140 IPKEKEKEI--------IFVGEALHKIRYNPQVTRAPDQIQGAITSRVQGY-PDKIQELLHQTNAYVPAAVAALLKERPS 210
XP_967648    161 IPLDTSDHL---PEMAQMAVNEAVSTIQNNPIDTLASSDIQNCIINKLKDY-PDKIQSSLHHATAYLPVGVAAILRHKPG 236
XP_001955876 173 LQNSAATSQ-----DAVISMANALQRIRLNPTLYRCSREIQSCIDTRLKEFqIAQPHFSIHRQVVELPQSAAQLLKQQPG 247
NP_001071738 139 VLKPASPSEidiLPIGDPTLLQALDAVSNYPWLTQASSSIISCIQKRISGF-P--CQDNVFHANVYLCESIVHLLDKNPS 215
Q949K3       157 IPNSVIPTT--------PSIHEALNLLRNVSS-TRAPEGVQRQLENRLKEY-PNRAEKNVHKVRVRVPLSVAKVLKHEPC 226 tomato
KRH39459     158 VPRNRLTN---------PSLIDSLNFVASSPHESLASDAIQRAIKKRISNY-PEQARNNMHRVRVRVPVSAASILKHEPR 227
XP_006381540 152 VPKSRLPN---------PKLIDSLKFLIDCEGESRAAESVQIAVKGRISDY-PERARRNMHQARVRVPVSVAQVLKQEPC 221
Q9LSM5       155 VPRSRLPD---------PSLVASLRFLIERGNESRASDSVQSALKNRISDY-PERAWRNMHRVRVRVPVSVAQVIRHEPF 224 thale cress
EDV96819     253 LVASAVRAFCDRDSLDTKALRTMRYFPP-----ESpRKRTNVAFTRCLYAMLMHNQYTPERRLGWQ-LTDAvAQPEaHKE 326
XP_001947588 237 LIAPAVIAFCHRDMLDVKACQTMKHFPP-----KE-RVMRTVTMTKCLYAMLIKQKCVPEKRTGWD-LVET-TDSR-YKA 307
4_pfamImport 211 LIAPAVSAFCHRDPVDMRACRAMRFFPP-----ET-RVMCQVKMSRCLYAMLLHHKYTPDRRTGWC-LPQQ-NSPD-YLA 281
XP_967648    237 LIAPAVQVFCNRDPVDAKTCKAMKYFPP-----EN-RVNARVTFTKCLYAMLTHSKYVPDRRTGWN-LPKS-DSPQ-FKA 307
XP_001955876 248 LVSSAVRAFCDRDSLDTKALRTMRFFPP-----EApRLRTNVGFTRCLYAMLMHQQYTPEKRLGWN-LTDSiAYPElYKE 321
NP_001071738 216 LISAAVQAFYLRDPVDLRACRTFTYFKP-----EN-RVWSQIPMTRCHYAQLMQQQFIADKRSGY--LPSSaLPPKqNKG 287
Q949K3       227 LISLAVEGFYDRDIDTMKFAAEMERFLGnggsgEE-LVRVLVTMSRAMYAQLVQQTFQAPKC--YPaLPPR-SDVGaYME 302 tomato
KRH39459     228 LISLAVEGFYDRDIDTMKFAARMERFVErg-ktEE-LVCVSVKMSRAMYAQLAQQRFQAPKC--YPeMPAR-SEREgFAE 302
XP_006381540 222 LISLAVEGFYDRDIDTMKYAAKMEKFLSkg-keEE-LVCVVIKMSRAMYAQLMQQKFQAPKC--YR-MPNRgDDLGaYLE 296
Q9LSM5       225 LISLAVEGFYDRDMDSMKHAAKMEKFLSkg-reEK-LVLVLVKMSRAMYGQLVQQKFQAPNC--YP-MPSV-SDRDaFSE 298 thale cress
EDV96819     327 QLLGVKLASGLEILASQAKra------gDEADEKSTAwRAYLRSLQSKGYFRDNVEGSAEYVRLLATAKEYFKSNQTr-- 398
XP_001947588 308 QITGIRIACGFEILVSQAKttvk--ddtPVDLTYDKRwHHYKSSLAEKGYFKNLYEGSNGYKLLEDQAKQYYLSNVDe-- 383
4_pfamImport 282 HSIGIKLACGFEILVSQCKvk------dGDDLENDKGwLRYKQSLQDKGYFNELLEGSVGYTRLETEAKEYYRAHA---- 351
XP_967648    308 QNLGVKIACGFEILAAQAKps--------qDIEQDKGwVNYFEKLKEKNYFRGLLEHSREYNDLLNKAKEYYINHRDs-- 377
XP_001955876 322 QLLGVKLASGLEILASQAKrv------dGQKLEEMPAwRAYLRSLQSKGYFKDNLEGSAEYQQLLSKAMDYFRGNQEr-- 393
NP_001071738 288 VDLGMKISHGLEILCSKVKptksaenpdAPALFDEDKfNSFVSYLKETGYFRNELEGSKLYNQLKIEAQKFFIENCVsdr 367
Q949K3       303 AELGMKIACGFEMIYQLKKr--------QGMDGKGSTwDAFRLSLERSGYFEGLLPGSKEYKRLMKNAEEYYKNSSLhar 374 tomato
KRH39459     303 AELGMKIACGLEMMYQQRKr--------DGEEGKGSSwEAFRKSLENSGYFQGQLPGSSEYQRLMQSAQEYYRSTSLhsk 374
XP_006381540 297 AELGMKIACGFEMMYQQRRr--------EGEEGKGSTwLKYKESLERSGYFEGFLPGSKDYKRLMENAEGYYRNSTLfsr 368
Q9LSM5       299 AELGMKIACGMEMMYQQRKk--------EGEDGKGISwSKYKDNLEKYGYFEGLLSGSKEYKRLMENAEEYHQKSSSfsr 370 thale cress
EDV96819     399 -FRTAPLVGAEIVDLL----LHtGEsSAAEQLRDEENNLLPSDADDWLNISAEDLDAMLQQRYGPQKLY----------- 462
XP_001947588 384 -YLSSPSISQRIKNIL----DSvTE-QELVQLKSDISDLEPADDETWLDVSPSDLDRILEQKFGLKNSE----------- 446
4_pfamImport 352 -MYSQSPIGKTVLDML-----NnLE-VDVEGMKRAENSLPPPDDDSWMEISSEDLDKILSERYG---------------- 408
XP_967648    378 -MHYSPAIGQEIVQLI-----KnLD-FKIDELKEESN--LPDDDDSWLNVSPEELDKMLEEKYGQKKFV----------- 437
XP_001955876 394 -FRTTPRVGAEILELL----LHpAE-AASEELRDEENNLQPSDSDDWLNISAEDLDSMLQDRYGPHKLY----------- 456
NP_001071738 368 nVPTEQDVLVNMVKMLkiwgKSgFPkLETLVIKDILEELPNESSDKWMYLDKNAVEELTKEMNLGFKNLhigkk------ 441
Q949K3       375 eSATLSAPVRRIDEILa------LP-DSADDFKDQE--IPPSDDDSWLYGGEDELNSVLQERQKEMELYnskrkqks--- 442 tomato
KRH39459     375 aSDLLNAPVRRIDEILa------LP-HSVDDFKDQE--VPPSDDDSWLYGGEEELNSVLMERQKEMELYdlkhkkkgkak 445
XP_006381540 369 tSQMMSAPVKRIDEILa------LP-HSADDFSCQE--VPPSDDDSWLYSGEDELNAALQQRQNEMDLYnakhkkkqmpk 439
Q9LSM5       371 tRDIMSAPVRRIDEILa------LP-YSEDDFKGQE--VPASDNDSWLYDGEDELNSVLQERQKEMEFYnskkerknkgk 441 thale cress
EDV96819     463 ----------NPNGDMNAAEFTKHLSQFLDQQSNFEGIEMpgeagnde---------------ldsdddePPpppksksa 517
XP_001947588 447 ----------QSSASNFASSFTDKIRSFLNQASDINGADFsknhlsddsddsddedkpdddklsnllvcgPDvmlptndd 516
4_pfamImport 409 ----------SNRPNTSVNDISTHLTSFLEHVSGLEGAEH------------------------------PLvnkdgvpl 448
XP_967648    438 ----------TVNNNSDAASFTEKISSFLNHVSDIDGVEH------------------------------PDldnsptrp 477
XP_001955876 457 ----------KPNGDMNAEEFTKQLSDFLDRQSNFEGIEHqgheld-------------------sdddePEprkpddst 507
NP_001071738 442 ------kkktADLSQETIKETVEKMKTFVGEVSGLEGVET---------------------------------------- 475
Q949K3       443 ---keqdgpsNHSDNFDLKDISNSMQAFVTKVASYEGAEV------------------------------PE-------- 481 tomato
KRH39459     446 egqdagpssaSNADEFDPSDIAKTMQAFVHKLSSYKGAEA------------------------------PE-------- 487
XP_006381540 440 esqdagpsssSNFDDFDLGEMAKAMQAFVDKASSYKGAEV------------------------------PE-------- 481
Q9LSM5       442 ekqeagsssdANMNNFDLGDISKSMQQFMHKVSSYKGAEV------------------------------PE-------- 483 thale cress
EDV96819     518 ssassshaakvkksasmrkACQRNSLIQSDEQDSTHVRNFLDFVIPEDnw-------dSNSDMSDYADEDDLQRNfdals 590
XP_001947588 517 kda-----vavrynkkknkINEKSNVNFEPEKYEAALRSILDFKIPEDnwd-----esNSSDMDSYGSDCD--------- 577
4_pfamImport 449 rpkr---gvkknksqdqtrDDDNNRISFDQEAFTCAVQNILDFAVPEDswd----lesEESGMSSYEDEVEMDLSrkkt- 520
XP_967648    478 prgvkkrtkvsfasgtkteTTANNRVSFDPNAFSCAVQNILNFVIPEDdsw----dldSGSDMSDYADDVAG-------- 545
XP_001955876 508 ssg-----akvkknpsmrkACQRNSLIQQEEPDSTHVRNFLDFVIPEDnw-------dSNSEMSDYADEDDLESNldrs- 574
NP_001071738 476 -------------------TNDITPVVFDVENFMLNVENMLGHA--ENms-------dESSSEFLTSDEE---------- 517
Q949K3       482 -------------------DRNVKEVDFDVDHFMKDLESFMRGQGNEDigrdv-dieeGSSSDMEFDESEDESDIae--- 538 tomato
KRH39459     488 -------------------DRN-KEVNLDVDQFIKDMESIMMHSDGEVansn---ieeGSSSDLDFDNS-DDSDIve--- 540
XP_006381540 482 -------------------NRNMKEVDLDVECFLNDMESVMKRYGPKDgaadv-dseeASSSDMDFDESEDESDIme--- 538
Q9LSM5       484 -------------------NRDFKEVSIDVDRFMKDIESMLGSQGRDEqadddsdgseGSSMDMDFDDVEDDSe------ 538 thale cress
EDV96819     591 sasasGGDDNYRLDRNIKAYMEQMDRELAQTTVGKSFHGKS-GTSNNTSPHHAAEDD----------FDDIEDFEPININ 659
XP_001947588 578 -----DIMSGSQAGASISSYMAQMDKELASTSLGSSFVKKPtSDKNKLQKTVRIDPTvqcqdseednFSDVEDFEPVDID 652
4_pfamImport 521 --dkrRESEDSQGKSELKQYMDQMDRELSKTTMGQSFHKKP-AKGMEDS------------------FSDIESFEPVDID 579
XP_967648    546 -----NEEMYEGVKNKMQEYMEQMDKELAATTIGESFEKKN-GDG----------------------FEDIESFKPVDID 597
XP_001955876 575 -lsgsGAGNVFPLDRQIKSYMEQMDRELAQTTVGKTFNGKK-KSA------QAEEDD----------FDDIEDFEPININ 636
NP_001071738 518 -----TDTDLEEEKNEIQEYMEKMDSELSATAVGKSFVKLK-SENAGVSENISTEE-----------QKLNDDNAPVNID 580
Q949K3       539 ----pHDDNDEGGAAFMHSYSDTLNDELKGTTLSNTFVRAN-GESESIKKDEGTSTAae------nmE--EEDFSPVDVD 605 tomato
KRH39459     541 ----lDEDNEDREDIFMRSYSDAMNEELKATTLQKSFVRAN-EQIP--KKDQGTSNAse------hiM--DEDFSPVDVD 605
XP_006381540 539 ----aSEDNVDGEDTFMNTYSDALNEELKNTTLKKSFVRTD-DQLS--KKNEETSNTme---------gmDEEFTPVDVD 602
Q9LSM5       539 ----gEESNEDAKESFEESYYGAMNEELKNSTLEKSFENVN-QQHSS-KQNEESSKTrd---------ekDDEFTPVDAD 603 thale cress
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