Conserved Protein Domain Family
TPX2
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pfam06886: TPX2 
Targeting protein for Xklp2 (TPX2) domain
This family represents a conserved region approximately 60 residues long within the eukaryotic targeting protein for Xklp2 (TPX2). Xklp2 is a kinesin-like protein localized on centrosomes throughout the cell cycle and on spindle pole microtubules during metaphase. In Xenopus, it has been shown that Xklp2 protein is required for centrosome separation and maintenance of spindle bi-polarity. TPX2 is a microtubule-associated protein that mediates the binding of the C-terminal domain of Xklp2 to microtubules. It is phosphorylated during mitosis in a microtubule-dependent way. The TPX domain appears to be truncated in fungal species.
Links
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Statistics
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PSSM-Id: 462029
Aligned: 81 rows
Threshold Bit Score: 33.7089
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EDO36718      135 VVLNSDKRAQERAIYEMQKHEKEMEEEAILRQREEEREEEERRNIAMLRQQMVHKANPIARFKGVQiLPSEKP-LTE 210 
EKC25469      765 FELNTEQRSHKRENFEMHKKAREAEIEAAKRQRERQKEEEEKAYVAKVRAEAVHKSQPIKRFKSVEvLPSDRP-LTF 840 
XP_009021853  435 FSLNTQQRAEKRAEWESYVKLKEQRKEEERLLAERRKEEEKLQETKKLRALTVHKANPAPNFRSSVav---lAvASA 508 
EFX86820      493 FSLTTVKRAAERKNFDQFLKEREQEKEMHKLRREQEKLQKESEQAARLREETVFFANPIRHFKTVEiKKADAEiLTV 569 
OWR53665      642 FDLTTTKRAAERELFEKQLKEKEEENERLRLQKEREKQEAEERAIAELRAKLVHHAKPVPALHPFIpGKSDAP-ITV 717 
XP_022532559  648 FQLSTERRAKERLEFERALKEKEALRAQVEEQESRDREEHEKEEIIRLRQEQVHKAQPIRRYKPVElKHSEAT-LTV 723 
NP_001314674  636 FQLATERRAKERLEFEKELSEREALRARMEEERAREREQQEKEEIARLRQEQVCKAQPIRHYKPVElKKSDVS-LTV 711 
XP_002129759  812 PHLHSDERAKERRLFDEKLAFEKQQMAKLLEEQKKKQELQDKEEIARLRKSMEHKASEIKHYKTVTvALSEKK-LTE 887 
5_pfamImport    1 FNLHSDERAKERQIFEEKLAQEREEKKRLIEEETKRKEIAEKEEIARLRRSMEHKATEVKHYTRVKvTHSEKK-LTE 76  
EDQ87412      653 FQLSSDLRAKKRREFDEAQAEQRRLQEEQEALARAAAEEQEQQEIRRLRNKLVHKASKIRSFKSVDiAPSQKR-LTE 728
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