1MZM,1BWO,1JTB,1CZ2,2B5S,1UVB,1T12,1SIY


Conserved Protein Domain Family
nsLTP1
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cd01960: nsLTP1 
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nsLTP1: Non-specific lipid-transfer protein type 1 (nsLTP1) subfamily; Plant nsLTPs are small, soluble proteins that facilitate the transfer of fatty acids, phospholipids, glycolipids, and steroids between membranes. In addition to lipid transport and assembly, nsLTPs also play a key role in the defense of plants against pathogens. There are two closely-related types of nsLTPs, types 1 and 2, which differ in protein sequence, molecular weight, and biological properties. nsLTPs contain an internal hydrophobic cavity, which serves as the binding site for lipids. The hydrophobic cavity accommodates various fatty acid ligands containing from ten to 18 carbon atoms. In general, the cavity is larger in nsLTP1 than in nsLTP2. nsLTP1 proteins are located in extracellular layers and in vacuolar structures. They may be involved in the formation of cutin layers on plant surfaces by transporting cutin monomers. Many nsLTP1 proteins have been characterized as allergens in humans.
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Statistics
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PSSM-Id: 238926
Aligned: 65 rows
Threshold Bit Score: 69.3009
Created: 23-Nov-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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hydrophobic
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:hydrophobic cavity
Evidence:
  • Comment:nsLTPs contain an internal hydrophobic cavity which serves as the binding site for lipid-like molecules. This cavity exhibits high plasticity to accommodate a variety of ligands.
  • Structure:1JTB; Hordeum vulgare nsLTP1 binds palmitoyl CoA; defined at 3.5A contacts.
  • Citation:PMID 9032083
  • Structure:1BWO_A; Bread wheat nsLTP1 binds two LPC phospholipid molecules; defined at 3.5A contacts.
  • Structure:1CZ2_A; Bread wheat nsLTP1 binds prostaglandin B2; defined at 3.5A contacts.
  • Structure:1UVB_A; Rice nsLTP1 binds two palmitoleic acid molecules; defined at 3.5A contacts.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #    #   #  #                #  ##        #  #  ##  #             #  ##    
1MZM        2 ISCGQVAs-aIAPCISYARGqg--sgPSAGCCSGVRSLNNaarttaDRRAACNCLKNAAAGvsg--lnAGNAASIPSKCG 76  maize
1JTB        1 LNCGQVDs-kMKPCLTYVQGgp---gPSGECCNGVRDLHNqaqssgDRQTVCNCLKGIARGihn--lnLNNAASIPSKCN 74  Hordeum vulgare
O04403     33 GPCGKVVh-hIMPCLKFVKGee--kePSKSCCSGTKKLSEevktteQKREACKCIVAATKGisg--ikNELVAEVPKKCG 107 Parietaria judaica
O04404     39 ETCGTVVr-aLMPCLPFVQGke--kePSKGCCSGAKRLDGetktglQRVHACECIQTAMKTysd--idGKLVSEVPKHCG 113 Parietaria judaica
CAB77978   32 RHCVMAQgqvISACLQQANGl-----PHADCCYAINDVNRyvetiyGRLALCKCFQEILKDs-----rFTKLIGMPEKCA 101 thale cress
Q41258     29 NICPRVNr-iVTPCVAYGLGr----aPIAPCCRALNDLRFvnt-rnLRRAACRCLVGVVNRnpg-lrrNPRFQNIPRDCR 101 onion
BAB10168   28 ADCAAVGt-lISSCTEFVNYgypdpiPGSSCCDAMTVIGTysdsseKRKWLCNCFMDLINVyn---snATAISTLSGFCG 103 thale cress
AAD04945   18 IECSDVLs-rPVHCLSYFVTpratltPTSACCRESEEVLGmansmgAKEDLCNCFVGLIRGfr---pnPNKIEGLLSSCA 93  Monterey pine
ABL11230   33 NDCAVAQt-aFGDCAGYVAGve--nkLSPRCCRALADIRDmaptfvRQRALCACIHKEMVAagk--vvTRRAAALPGRCG 107 barley
BAD46431   32 DLCGLAEt-aFGECTAYVAGge--paVSRRCCRALGDIRDlaataaERRAVCACILSEMLAagdgrvdSGRAAGLPAACN 108 Japanese rice

Feature 1       ###    ##      
1MZM       77 VSIPYt---ISTSTDCS 90  maize
1JTB       75 VNVPYt---ISPDIDCS 88  Hordeum vulgare
O04403    108 ITTTLp--pITADFDCS 122 Parietaria judaica
O04404    114 IVDSKlp-pIDVNMDCK 129 Parietaria judaica
CAB77978  102 IPNAVp---FDPKTDCD 115 thale cress
Q41258    102 NTFVRpf-wWRPRIQCG 117 onion
BAB10168  104 VVLGFt---IDPNTDCN 117 thale cress
AAD04945   94 LQLFFpidpVTALPDCT 110 Monterey pine
ABL11230  108 VRISFl--pTTHNFDCS 122 barley
BAD46431  109 VRVGFi--pTSPNFNCF 123 Japanese rice

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