5YU6


Conserved Protein Domain Family
Exportin-5

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pfam19273: Exportin-5 
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Exportin-5 family
Exportin-5 mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). Exportin-5 yeast homolog, also known as Msn5, is involved in nuclear import of replication protein A and export of Far1 and transcription factors Swi5, Swi6, Msn2, and Pho4. Its Arabidopsis homolog, HASTY 1, is involved in the nuclear export of microRNAs (miRNAs).
Statistics
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PSSM-Id: 437105
Aligned: 9 rows
Threshold Bit Score: 841.705
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5YU6_C        313 EKHYVFLKRLCQVLCALGNQLC------ALLGADSDVetpsnFGKYLESFLAFTTHPSQFLRSSTQMTWGALFRHEILsr 386  human
Q54PQ8        308 EDDYSFHKRITQALTILGTVHL------NAYDDKHKIpn--nYNIYLQLMLQMVSHPSILLSSFVLPFWHTFIKVESLel 379  Dictyostelium...
O14116        330 TPEYILLKKLSETIVALGQYNYldsnrrKCIKLTS-------LDTYSLLVLEIMKHPSLLISAISQHFWVLALRDPIIsk 402  Schizosacchar...
P52918        332 ETKYPIIKKFVDMISCLY----------VCVPKIKETng--qIQKYFKLVLKTTYNPSLIVSGLTLDLWCTCLRNDEYlp 399  Saccharomyces...
XP_002272927  313 ESEFEFAEYICESMVSLGSSNL------QCITGDSTI-----LSHYLQQMLGYFQHVKLTLHYQSLPFWLALMRDLVSkp 381 
XP_002973645  303 SAPLEFAECLCEALVALGSQNL------QVISSNNQK-----LATYYRQMLKFLQHSEFSLHVQALPLWLGLLRDSLSve 371 
PNR50684      319 EDVDQFGECLCEAMVAFGLQNL------HCVARNSPK-----VTDYLNQMLCFLQHPKLALHSLALPLWTTLLRESSLam 387 
AQK91597      281 ESEYEFASCVCETMVALGSSNM------QCILADGAR-----TFQFLQQMLEYYQHYKITLHFQSLLFWLVVLREP-Sks 348 
KMZ72157      314 ENEMEFMDVFCESMVSLATSNM------QCILRESTT-----LSLYIQQMLGYFQHFKFAIHFHSLPFWLLLLKGISPrg 382 
5YU6_C        387 dp-------------------------------lllaIIPKYLRASMTNLVKMGFPSKTDSPSC---EYSRFDFDSDEDF 432  human
Q54PQ8        380 sy--------------------------------leeVIKQIMETMLVKFVRIGDPEKSDSEQS---KYSEIDFGTSKEW 424  Dictyostelium...
O14116        403 he-------------------------------kfqiVYPELLSIASERLLRFEDAVVELIPESataKYLQEDVEGVSAV 451  Schizosacchar...
P52918        400 kl--------------------------------ekyVIPDLLQFAADALVYYEQIDGHISk-----KFAEIDFQSKSEF 442  Saccharomyces...
XP_002272927  382 kivapaagdgsvdnnpgsgsgqvdnekrklqsfvnddICGTMLDVCFQRLLKREKVLPGTSFSLgplELWSDDFEGKGEF 461 
XP_002973645  372 rnkviia---------------------rptvvvpieTASVLLDVAFQKLLKDGQ---------------EEEFTSAVDY 415 
PNR50684      388 sttdqqglteke------------kekrshavhispdFCAVLLDVAFQRLLIKDGGDTSAEDESg-----iQEFSSANDF 450 
AQK91597      349 ksiarvsgdnsaagnsastgdlstekkkgvsvfvtdeIYSTILDVSFKRMLKNN-----GSATSgllEIWSEELEGKSDF 423 
KMZ72157      383 hnsvqssidnstasisgsasvqadndkkalillinddICAAILDLSFQRFPKRI-TSTGEPFAAgslELWSDDFDGMVEF 461 
5YU6_C        433 NAFfnssRAQQGEVMRLACRLDPKTSfqmaGEWLKYQLSTFLDAGSVNSCSavgtgegslcsvfSPSFVQWEAMTLFLES 512  human
Q54PQ8        425 SNFfggvRTRYLDIIKLITIQRREMAyifiATKVADVLDALKANLNVASLS-------------HEQTLVLESHSHILDS 491  Dictyostelium...
O14116        452 HSFcgnfRRFMFDIVRLTVSITPIES----LNWIQNRFQSTVLGNMEDIQSqtef-----fsktSPLYLTMDVGFSTIEA 522  Schizosacchar...
P52918        443 QTFcstyRKRIRDIIRLISCVELDLT----YDWLNNRLNNYFSSPFGQQVLsstf-----ldhkLEPYLGALSQYMIVEC 513  Saccharomyces...
XP_002272927  462 SQY----RSRLLELARFVASDKPLIA----AIKVSERIATIIKSLLLSPMS-------------AQDIAVMESMPMALEN 520 
XP_002973645  416 SQY----RGRLIELIRLVAHHHHDLG----ITKVVQRLDVFLTK---EKIS-------------SQEYFILESTHTMLDA 471 
PNR50684      451 RQF----RSRLVELVRHVAAQQPRLA----TSKAAERLQMTISSSNYESVS-------------SKEITALETTQTYLEN 509 
AQK91597      424 CNY----RTKLLDLIKVIASQRSVIA----AAIVVQRINVVFGDANQATKS-------------PQDLDAMEGAQLGLEA 482 
KMZ72157      462 GLY----RSKLLEIIKLVVFHKPLLA----VTNISNRINSSINGGPNTS-P-------------INAMSLLECWQPGLET 519 
5YU6_C        513 VITQMFRTLnREEIPVNDGIE-----------LLQMVLNFDTKDPLILSCVLTNVSALFPFV-TYRPEFLPQVFSKLFSS 580  human
Q54PQ8        492 ILLNIKDFTpESSLFFNKEQQqqpniiqltdrVLNLLFEINSTEPNITSFQIDCLQAYILYY-QTNPESIKFLLNKIVPL 570  Dictyostelium...
O14116        523 FLHGVTRWNeN----TSDDPAtyeiilqnlflWCKQLVEINFKDPMLITRLISVLVLFTSILaRENTTLLGVVLEKIISA 598  Schizosacchar...
P52918        514 FINGCIRWKiWYPTGDDYDEKldsil-qkleiLSNQLIALNLREPLLLKKQIQNFALFLTML---KDNVLFTLLEKIITS 589  Saccharomyces...
XP_002272927  521 IASVVFDGS-NEYLGGSSETQlalcr--ifegLLQQLLSLKWTEPALVEVLGHYLDALGLFL-KYFPEGVGSVINKLFEL 596 
XP_002973645  472 VVTGCFARGgtse---------------llggLLQRLLTVHWSEPELVEIHAKCFDALVPYI-KNVPTAVPTVIQKLFQL 535 
PNR50684      510 ILNGIQEKTlAAALATTASSNelrt---iledILQLLLSVKWNGPALVELHTRHFDAMSPYF-KHASAAIPLVVGKFFDL 585 
AQK91597      483 VVNAIFDGS-VDCGKTDLDTKsqlhk--ifegLLQQLLSLKWTEPNLAVIHGHYLDALGPFL-KHHPDAVASVVNKLFEL 558 
KMZ72157      520 IINSTFD---ETKVCINSEIKleihr--ilegLLQQFMHSKTNDPAHAIILGRYLNTFGPFL-KCFPDSVGGVVNKLFEL 593 
5YU6_C        581 VT----FETVEESKAPRtRAVRNVRRHACSSIIKMCRDYPQLVLPNFDMLYNHVKQlLSNELLLTQMEKCALMEALVLIS 656  human
Q54PQ8        571 IP----FPGLDNPNRSFqNSVLHTRRRAISSLIGISTNISHLMKPYFDILYKSVVE-LFQKNVVTETEKVMLFHLLIVFS 645  Dictyostelium...
O14116        599 VTydntSASYGFSDV---QKINEMRSRCCFELVRLGELMPNPLMNIFDQLQSIIDQ-LDNATTLTGSEIVMLKTFLFVIT 674  Schizosacchar...
P52918        590 ATmdypEINLEERGAES-DAVRDLRYACGIELNRMALLMPESLKKIYPDLESVIARiMPN---LSYHEKISFKSFLLIIV 665  Saccharomyces...
XP_002272927  597 LT----SLPFVVKDPKT-SSARYARLQICTSFVRLAKSAEKSLLPHMKGIADTMDY-LQREGCLLRAEHNILGEAFLVMA 670 
XP_002973645  536 LV----TVPVVSKEASStNS--KARFQVCTSFLRIAKLAGPALFPHMQIVAETMTR-LQQERHLLRGEYILLGESLLVAG 608 
PNR50684      586 LT----SLPVYREYGDTvKDTMRARLQVCTSFLRLARAGDAAMLPYMQGIAETMTT-LHREGRMVRSELNLLGESLLIVG 660 
AQK91597      559 LT----SLPITFQDPS--NNSRLARLQICSSFIRISRAADKALLPHMKNIADTMAY-LQGEGRLLRGEHNHLCEAFLVMS 631 
KMZ72157      594 LT----SLPLVLSDPST-NNVRLARLQICTSFIRIAKAADKSLLPHMKGIADTMAY-LETEGRLLRSEHNLLAEAFLVMS 667 
5YU6_C        657 N-QfKNYERQKVFLEELMAPVASIWlsqdmhrvlSDVDAFIAyvgtdqkscdpgLEDPCGLNR----------------- 718  human
Q54PQ8        646 N-NlPSYQQTLDFYKGILTPIIEQW---------VSLEMSTA------------LSSPDAFIQylglsiads-------- 695  Dictyostelium...
O14116        675 QfSdVNIEVKNEYFEKLVGPVVKTW---------LDVQPP--------------VNSPMEFLNhigfpqmaeylsakypy 731  Schizosacchar...
P52918        666 L-K-SSLDMKEERFAAIVDPELLAWsdkttvvglSDLHW---------------FMERLGIVQiaeyfqrrdidensdll 728  Saccharomyces...
XP_002272927  671 S-V-AGVQQQQEVLAWLLEPLSKQW---------IQVEWQQTy-----------LSDPTGLIRl---------------- 712 
XP_002973645  609 S-T-AGQEQQNQVLEWLLGPFRDYW---------CHSDWQQKy-----------LCDPAGFVRl---------------- 650 
PNR50684      661 S-A-AGGEQQLQVLGWLFGPMQQQW---------IQPAWQDQy-----------LANPASLVRl---------------- 702 
AQK91597      632 S-S-AGIQQQQEVLAWLLEPLNKMW---------TQVEWQTAy-----------LSDPSGLTNm---------------- 673 
KMZ72157      668 S-S-SGQLQKQEILAWLLEPLNKQW---------TQLEWQISf-----------LSDPLGLTRl---------------- 709 
5YU6_C        719 ---------------------ARMSFc-------VYSILGVVkrTCWPTDLEEAkaggfvvgytssgNPI---------- 760  human
Q54PQ8        696 -------------qnldatlvSRRKN--------IQYVASTL--QIFWKKSQIP-------------TNSsdelfapfis 739  Dictyostelium...
O14116        732 nadytqfeldadaasyqsnleTGRKW--------LWPIKCLG--RFCEATCSNK-------------------------- 775  Schizosacchar...
P52918        729 -----sipiddegkelkseltKRWQS--------LFPVRATR--MFIHYSMQSIktdeefkmlqdlwRPR---------- 783  Saccharomyces...
XP_002272927  713 --------------------cSETSF--------MWSIFHTV--TFFERALKRSgirkg---slnsqNSStas------- 752 
XP_002973645  651 --------------------lGTTTTenlsgdegMWYIFHSI--HFFEKALRRC---------------Aagve------ 687 
PNR50684      703 --------------------fTENSSndda-haeMWSIYHTV--NFFERALRRCanps-----gktySGSsatvhnvdmd 754 
AQK91597      674 --------------------fADSQF--------MWSIYHTV--TFFEKALKRSgtkks---satpqAPTttv------- 713 
KMZ72157      710 --------------------cSDAQF--------MWSIFHTV--AFFERALKRSgirkg---hgslqACTsavd------ 750 
5YU6_C        761 ------FRNPCTEQ---------ILKLLDNLLALIRTHNTLYAPEMLAKMAEPFTKALDMLDAEKSAILGlpq------- 818  human
Q54PQ8        740 ngisynGKWPISSF---------VKQVLPGVLSLTRTLHQLWMPEHRAKIHPSLSTIFNLDDSITAPLLG---------- 800  Dictyostelium...
O14116        776 ------HIHPSEFEgqknlwqviLPNVVPNLLKLVEQLHCCYEPSFISGLGMHNSSILQKSIVERFWLHGvsqis----- 844  Schizosacchar...
P52918        784 -----------------------IVPILPYITRLLYQLQSYHDPDNWKGLPTVVQSFVKYSTIERFWEAGasnks----- 835  Saccharomyces...
XP_002272927  753 ----ftPLHPMSSH---------LSWMLPPLLKLLRAIHSLWSPPVSQSLPGEIKAAMIMSEVERTSLLGevnpklsks- 818 
XP_002973645  688 ---gnpSSHPMAVH---------MSWILPPLIQLLRCLHSLWIPSILSTLPPPVRQAIHLSASEQASILGe--------- 746 
PNR50684      755 gavtpaSSHAMIQH---------LTWMVSPLLKLLRCIHALWSPSVASSLPPQVQGALTMAEAEQASLLGelattrgpag 825 
AQK91597      714 ----pgYLHPMSSH---------LAWIVPPLLRLLRCIHVLWSEPFAQSQTAEIKAAKSMTVAEQASLLGetgkltkg-- 778 
KMZ72157      751 ---gsvSQNPMLSH---------LSWILPPLIKLLRCIHSLWSHQVANSLPLEMRAAMSISYTEKAGLLGevvskqtkg- 817 
5YU6_C        819 ------------plLELN--DsPVfKTVLERMQRFFSTLYENCFHILGKAGPsMQQDFYTVEDLATQLLSs-AF------ 877  human
Q54PQ8        801 --------------FEYHk-EqKSeSSNVTFLRNILDCLRDACYEIVGYGFN-HSDELFSLPDLPLVLLDs-VF------ 857  Dictyostelium...
O14116        845 ----------knqfLEESykMdVSaNKLIHSFGHFLRRLREYCYYAIA-SFMrLGQAFFCVPGLSKQFLTa-FF------ 906  Schizosacchar...
P52918        836 ----------kdefIDEHmkAmQTlRDFADSVGHIIRYTREYTLLVLSAISS-LGSVFYLLDESPDLLLNsiAIfkpgsn 904  Saccharomyces...
XP_002272927  819 -----vagfidgsqIDTNk-E-YA-ESHETDIRNWLKGIRDSGYNVLGLSTT-IGDSFFKCLDISSLAIA--LM------ 881 
XP_002973645  747 ---------------------sKTvDHKEDELRNWLKSVRDSGYNVLRYASSrLGNQFFVNMSGLSGPLAtgLM------ 799 
PNR50684      826 assmtdkgvdagssIEHNk---------VKEIRTWIKGIRDAGYNILGLAAIrLGEGFFVDTDGRPAAMAtaLL------ 890 
AQK91597      779 ------qvapadglLDVQr-Dg---ESKENNIKNWLRGIRDSGYNVLGLAAT-LGEAFFRCIEGSSVTLA--IM------ 839 
KMZ72157      818 -----llassdghqMEGNa-DgHA-ESGENSLRNWLKAIRDSGYNILGMSAS-IGEYFFQCLDSSSVTLA--LM------ 881 
5YU6_C        878 VNLNNIPDYRLRPMLRVFVKPLVLFCPPEHYEALVSPILGPLFTYLHMRLSQKWQVINQRSllcgede---------aad 948  human
Q54PQ8        858 SYLESIENRHLKLLVKHILNYLIKNCPTKLEHTIFEPILPLLFSVLFNRIKAGWELIKLRSqkge--------------- 922  Dictyostelium...
O14116        907 SHAAGLSLHQWTSMVNVVIKPYCVNCPAELRDECLLPLLPALLSELDHKLVSEWRRINDRGllveedae-------etge 979  Schizosacchar...
P52918        905 EISPGVSTHGWKHIMNIAIRPILKGCPKDCLGKFMPAFLPKLFEILDLLLCQKWS-----Shmndmdmn------pvptd 973  Saccharomyces...
XP_002272927  882 ENIQSMEFRHIRQLIHSVLIPLVKFCPSDLWEEWLEKLLHPLFIHSQQALSCSWSCLLREGrarvpdvh-------aila 954 
XP_002973645  800 ESLSSMEFRHLRSLVHSVIQSFVRFCPHSLREVWLGQLLPPLLVHCHATLPLAWENLVREGavktgtlf-------avdg 872 
PNR50684      891 ENIEHMELHHIRQLLHLVVIPVVKVCPANLWDPWLRLLLPPILIHCHRVLSISWTSLIKEGalnipsnwslntdvsnqss 970 
AQK91597      840 ENVQVMEFRHLRQLIHLVIIPFVKYCPADLW-LWLVNLLQPLFVHCQQALNYSWSSLLHEGrakvpdsi-------gnls 911 
KMZ72157      882 ENVQSMEFRHIQKLVHLAIIPIVRYCPPDLRKLWLHNLLLPLFLHCQQALSCSWSGILHEGrakvpdrf-------gdls 954 
5YU6_C        949 enpESQEMLEEQLVRMLTREVMDLITVCc----VSKKGAdhssappadgddeemmatevtpsamaeltdlgkCLMKHEDV 1024 human
Q54PQ8        923 kenEKNEIVEDKILRDVSMEFLMCCSNI-----ITQSPN---------------------------------YIFSSIDV 964  Dictyostelium...
O14116        980 dddLSEEMIEESLLRHLTYATAKLITETfl--qITPTQSrsnvsssligk-----------etvegpvklseYVLDNAII 1046 Schizosacchar...
P52918        974 ddqMTEEILEENLLRQLTTVVVRIVIDCvgqgnANPNSAksrlnnh--------------------qmemrkIIFNDLNT 1033 Saccharomyces...
XP_002272927  955 gsdLKVEVMEEKLLRDLTREICALLSVL-----ASPGLNtglpsleqsghvsrgdmsslkdldafastsmvgFLLKHKGL 1029
XP_002973645  873 ssgINTELVEERMLRELTREVCTLLAIM-----ASSELNpeqqp------------------------gmlcYVIQHSAA 923 
PNR50684      971 mqqIQSEVMKEKLLRDLTRETCQLLSTA-----ASPTHNratqqdasegdggsme--vvgtqqlnkmnnlvwFLLQLREA 1043
AQK91597      912 gseLKVEVMEEKLLRDLTREVCSVLWAL-----SSPGLNnglpsleqlgpsnrmd-svlknlesfasssltgFLMLHIGT 985 
KMZ72157      955 gldLKVEVMEEKLLRALTREICQLLSFV-----ASPSLNngippieqfgntqsvaisslkdldtftsnslvcFLLVNKDL 1029
5YU6_C       1025 CTALLITAFNSLAWKDTLSCQRTTSqLCWPL-----L-KQVLSGTLLADAVTW-LFTSVLKGLQMHgQHDGCMASLVHLA 1097 human
Q54PQ8        965 MTPMVYGISSCLMAMDTPILKKSLI-VSTQLl---vD-HEKVNDPKFFKLIGSeMFGCCIKILIVN-KFAEFSNDIQSII 1038 Dictyostelium...
O14116       1047 CEPLLCTLCHLLVIHDSRTVGLVVNaFLAITp---lL-VSEQAHSLVREFICQqVFQSVILAIHDP-YFESMQSDFIRLA 1121 Schizosacchar...
P52918       1034 LAPFLKLLNHLISFKDTKCS------FNSILvmkccLtSVLNQNNTVDEYFTFeVMKNLLLNVLCNsAFKDSFHEALYAF 1107 Saccharomyces...
XP_002272927 1030 ALPLSQISLEAFTWTDGEAVTKVSS-FCGVVv---lL-AISSSNVELREFVAKdLFYAIIQGLALE-SNAFVSADLVGLC 1103
XP_002973645  924 AFATVHLGIQSLQWPDSDAVHRGAV-FCGAVi---dV-AGPLNDTNLREIVGKdMFTAIIQSLTLE-SNSAAHAELLGLL 997 
PNR50684     1044 ATAALHVGIDALEWPDSESVHKAFV-FCAAVt---nV-ATLSGDSQLQEVVAKdMFSSAIRALMLE-SNASAQSELVGLL 1117
AQK91597      986 ALPALRISVEVFTWTDSDAVTKVIP-FCGALi---hL-AVASNQAELRQFVAKdLFSSIIHGLSVE-SNSVISAELVGLC 1059
KMZ72157     1030 ALPVLQIIIKAFSWTDGEAVSKVAS-FCSTMi---lL-TISTKNIELNQFVVKdLFSAIIGSLTLE-SNALYGSDLVELC 1103
5YU6_C       1098 FQIYEALRPRYLEIRAVMEQIPEIQKDS--LDQFDCKLLNPSlqkvADKRRKDQFKRLI-------------AGCIG--- 1159 human
Q54PQ8       1039 RLIYMKYYQICNYPQEILLSLPNITPPI--LQAFNKDLISTR----SEKSQKVLFKKLL-------------QDVIGipl 1099 Dictyostelium...
O14116       1122 CIILSYSQGITDSAFQLLASIPALANQEnlVPAFFNKFREAS----TLKIQKALLTRLL----------------NSgri 1181 Schizosacchar...
P52918       1108 TVIFLTLCKEYPSARAFLFEISNGYN----IDELYRNLRSVD----EYKTQRALMIDFIdwvkstsgkedgnVDHAGder 1179 Saccharomyces...
XP_002272927 1104 REIFVYLSDRDPSPRQVLLSLPCITPYD--LLAFEEALAKTS----SPKEQKQHMKSLL-------------LLATGnkl 1164
XP_002973645  998 REILVKLSPHTSTPKQVLMSLPSISQQE--FANFETAFNKTT----SVKEQRQHIKNLL-------------LAAGGdkl 1058
PNR50684     1118 RDIYLQIGSRLSTPRQVLLALPSISPDS--LSTFETALHKTA----SAKEQRQLIKSFL-------------LSAGGdql 1178
AQK91597     1060 REIYVYLSDRDPAPRQVLLSLPHIKQED--LLAFNDSLSKTA----SPKEQKQHMRSLL-------------LLATGnkl 1120
KMZ72157     1104 RLVFVYLSDRDPTPKQILLSVPGIKMED--IVALKESLEKIN----SPKEQKLQMKSLL-------------LLATEnkf 1164
5YU6_C       1160 KPLGEQF 1166 human
Q54PQ8       1100 NKLKKES 1106 Dictyostelium discoideum
O14116       1182 VPRTDRR 1188 Schizosaccharomyces pombe 972h-
P52918       1180 KRQEKRE 1186 Saccharomyces cerevisiae S288C
XP_002272927 1165 KALAAQK 1171
XP_002973645 1059 KALKPQK 1065
PNR50684     1179 KAFIPQK 1185
AQK91597     1121 RALAAQK 1127
KMZ72157     1165 RALVSQR 1171
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