3EBQ


Conserved Protein Domain Family
Peptidase_C97

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pfam05903: Peptidase_C97 
PPPDE putative peptidase domain
The PPPDE superfamily (after Permuted Papain fold Peptidases of DsRNA viruses and Eukaryotes), consists of predicted thiol peptidases with a circularly permuted papain-like fold. The inference of the likely DUB function of the PPPDE superfamily proteins is based on the fusions of the catalytic domain to Ub-binding PUG (PUB)/UBA domains and a novel alpha-helical Ub-associated domain (the PUL domain, after PLAP, Ufd3p and Lub1p).
Statistics
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PSSM-Id: 461775
Aligned: 29 rows
Threshold Bit Score: 90.472
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3EBQ_A      9 YPVKLYVYDLS---KGLARRL-------------SPIMLGKQLEGI--WHTSIV-------VHKDEFFFgS--------- 54   human
O56042   1040 HSYATISYDYVlpkTGGNRRVlcfagvgdpnpynLP--TGDKNVGIgsYMVEFD-------IIGLDKDTgVkvmrpvpwk 1110 Rice ragged stunt...
Q7SF35     22 TEILINVYDLL---PPGRISS-------------TLWFLG--T-SL--LHSGVV-------INGREYAYgGhth----rg 69   Neurospora crassa
Q8X1T0      1 MKVYINVYDLMpdsPVNK----------------LAWTLGL---GI--YHTGLV-------LEGKEYAFgAhei----pg 48   Schizosaccharomyc...
Q6H6I0     10 TPVLLNVYDLTpanD-------------------YLYWLGF---GV--FHSGIE-------VHGMEYGFgAhdf-----p 53   Japanese rice
Q93VG8     26 TPVYLNVYDLTpvnN-------------------YLYWFGI---GI--FHSGIE-------AHNLEYCYgAhey-----p 69   thale cress
O49393     17 VPVYLNVYDLTpmnV-------------------YGYWLGI---GI--YHSGLE-------VHGVEYGYgAhek-----s 60   thale cress
Q6NQ19     18 VPVYLNVYDLTpinG-------------------YAYWLGL---GI--YHSGVE-------VHGVEYGFgAhdh-----s 61   thale cress
Q8LA90     15 VPVYLNVYDLTpinG-------------------YAYWLGL---GV--YHSGVE-------VHGIEYAYgAhey-----p 58   thale cress
BAD72532   44 SPVYLNVYDVTpanG-------------------YARWLGL---GV--YHSGVQgmyallsSPSILYAYgAhdg-----a 94  
3EBQ_A     55 -GGIS------------------SCPPGGt----LLG-PPDSVV-----DVGSTEVTEEIFLEYLSSLGESlFRGEAYNL 105  human
O56042   1111 qCGYTeeqvwsiyktlgkeyrkvELKPYTvedawRVIaKSSHKRvlsdkAIISTPISYERQRAIEYMLSS---HGFDYNL 1187 Rice ragged stunt...
Q7SF35     70 kTGVY------------------WTAPRTe----PPGgTFRCEL-----LHGFTLATPAEIDAIIREASEE-FLGTAYNL 121  Neurospora crassa
Q8X1T0     49 sTGVF------------------ATMPRPp----LEGcRWRCSI-----ALPNCTLPKPDVDRILIRLSQE-FTGLSYSL 100  Schizosaccharomyc...
Q6H6I0     54 sSGVF------------------EVESKS-----CPGfIYRKTV-----WLGTTDMSHGEYRSFIEKLAGK-YHGNSYHL 104  Japanese rice
Q93VG8     70 tSGVY------------------EVEPRN-----CPGfIFRRSV-----LLGTTSMSRSDFRSYMEKLSRK-YHGDTYHL 120  thale cress
O49393     61 sSGIF------------------EVEPKK-----CPGfTFRKSI-----LVGETEMKAKEVRSFMEKLSEE-YQGNKYHL 111  thale cress
Q6NQ19     62 tTGIF------------------EVEPKQ-----CPGfTFRKSI-----LIGRTDLDPENVRVFMEKLAEE-YSGNSYHL 112  thale cress
Q8LA90     59 sTGIF------------------EGEPKQ-----CEGfTFRKSI-----LIGKTDLGPLEVRATMEQLADN-YKGSSYNL 109  thale cress
BAD72532   95 gSGIF------------------EVAPRR-----CPGyAFREAI-----LVGTTELTRAEVRAVMADLAAD-FPGDAYNL 145 
3EBQ_A    106 FEHNCNTFSNEVAQFLTGRKIPSYITDLPSEVLSTPFgqalRPLLD 151  human
O56042   1188 VLNNCQDFTRGLFDYARGGPVPDFIENDVRIAMIHSTsr---hfAE 1230 Rice ragged stunt virus (isolate Thailand)
Q7SF35    122 LTKNCNHFTSHLCQKLTGLPGPAWLNRAASIGV---AlpcmVPKDW 164  Neurospora crassa
Q8X1T0    101 LERNCNHFTNAAAIELTGSPIPSFLNRISRIGLAFPTi---TNALL 143  Schizosaccharomyces pombe 972h-
Q6H6I0    105 VSKNCNHFTDDVCKNLTGKPIPSWVNRLARVGS---FfdclLPESV 147  Japanese rice
Q93VG8    121 IAKNCNHFTEEVCLQLTGKPIPGWINRLARVGS---FcnclLPESI 163  thale cress
O49393    112 ITRNCNHFCNHVSLKLTHKSIPSWVNRLARLGF---LcncvLPACL 154  thale cress
Q6NQ19    113 ITKNCNHFCNDVCVQLTRRSIPSWVNRLARFGL---FcncvLPAEL 155  thale cress
Q8LA90    110 ITKNCNHFCDETCIKLTGNPIPSWVNRLARIGF---McncvLPATI 152  thale cress
BAD72532  146 VSRNCNHFCDAACRRLVRARIPRWVNRLAKIGV---VftcvIPGNG 188 
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