Conserved Protein Domain Family
zf-C4H2

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pfam10146: zf-C4H2 
Zinc finger-containing protein
This is a family of proteins which appears to have a highly conserved zinc finger domain at the C terminal end, described as -C-X2-CH-X3-H-X5-C-X2-C-. The structure is predicted to contain a coiled coil. Members are annotated as being tumour-associated antigen HCA127 in humans but this could not confirmed.
Statistics
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PSSM-Id: 462963
Aligned: 24 rows
Threshold Bit Score: 177.57
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001967001  20 AIKDIRDKTLALEKLKVRIIKEVKLSDDEEKCLEEYRKEMEHLLEEKMSHVEELRQIHADINDMENIIKQTKENQTRSFD 99 
AAI62002      13 SIKEIRNKTLQMEKIKARLKAEFEALESEERHLKEYKQEMDLLLQEKMAHVEELRLIHADINVMENTIKQSENDLNKLLE 92 
XP_002113013  18 mVRGIRNKVQLLDKLKSKMQKELELISGEEKKLQEFTSEIELLQEEKMNHVEALRLIHADINSMEAIIKQTDQECHQCRN 97 
EGT59635      25 KVANAKTKVADYFAKKNELYEEIDELKNTENFIKETAKTIDELNKEKEEHSEIILLINQDKSDLEREIAEAESERKERED 104
1_pfamImport   1 KVQNARSKYDDYNSKRNELLEEIGELENTIKFIKETSKTIDELNKEKEEHSEIIQLINQDKHDLEREISAAETEKKEKES 80 
CAP23824      29 KVANAKTKVDDYFAKRNELLEELSELENTEKFIKETAKTIDELNKEKEEHSEIIQLINQDKSDLEREIAEAESEKKEREG 108
EGT59638      35 NIGKLRNGIDEFHKLADEIRKEEEAVKALEHHIANCNGVKTELDLERRNHAEELRQINQDINSLEDITKSTNSEIEKRKR 114
XP_015788909  24 CLKELRDVTLELSKKKARLHSALEAMDEEAKCLETFKNEKALIEQEREAHCAELLLIRDDLNQMESVIQESESETDHHLA 103
XP_015790456  21 YLKELRDVTFELNSIKSRLKQEMDSMEAEKRCLLAYRKEKEFLEQEKTAHVEELRLIHSDLNQMENVIKESDEEHSQHLA 100
XP_015781488  24 YLKELRDVTFDLNSLKSRLKQEIETMESEKNCLSVYRKEKEFLEQEKMAHVDELRLIHSDLHQMESVIKESEEEHNNHLN 103
XP_001967001 100 MANRVYEEYLALKYQIDHMRRDYLGLSPLRDLHEEEGSPISKERFQTNFlkaaaaaaaaataasvtqptslarpharhpl 179
AAI62002      93 STRRLHDEYKPLKEHVDALRMT-LGLQRLPDLCEEEEKL-SLDYFEKQK------------------------------- 139
XP_002113013  98 NIQRTHKEYNELKYEVDKMRSS-LGLESLPGLEDDDRNLFT-GIMKAQEts----------------------------- 146
EGT59635     105 KIKKKYEALLKLMEATNEKLKE-TGCD----ISLNQDDLPKTHI------------------------------------ 143
1_pfamImport  81 KIVRKYEILLKLMEQTNDRLKE-SGID----VAINQDDLPQTNL------------------------------------ 119
CAP23824     109 KIVKKYELLMRLMEATNEKLKE-TGCD----IALSTDDLPQTHL------------------------------------ 147
EGT59638     115 KITSVMAEVDRMRSFINENLESMNIIHKLES--SEEEELFKETV------------------------------------ 156
XP_015788909 104 MAKSLILEWQKLADRANKIRSA-LGLNQLPNLPEEEK--LKEDIIKSTGsedgahhhamafeqdnafkp----------- 169
XP_015790456 101 TAKSLLIECQQLKDHANKMRSG-LGLGLLNDLQDEEEK-IRLELFKKHQlnessnrdfeand------------------ 160
XP_015781488 104 AAKSLLQEWQQLKEHANRMRTE-LGLNRLSELSDEEDK-IKHELFKGQHvtnhvhsnnesint----------------- 164
XP_001967001 180 mpeatvttlpnaggagggaagaggggagalgggscgglgyekltfmraaetyapraaiaraavVRLGKGDFSAPPPPP-- 257
AAI62002     140 ---------------------------------------------------------------AEW---QTEPQEPPI-- 151
XP_002113013 147 --------------------------------------------------------------kIIH--TEVKPPLPLA-- 160
EGT59635     144 ------------------------------------------------------------------KIELSTTPAPPIf- 156
1_pfamImport 120 ------------------------------------------------------------------KIEPSTAPATPVl- 132
CAP23824     148 ------------------------------------------------------------------KIEPPTSPVTPVi- 160
EGT59638     157 ------------------------------------------------------------------ERQSCNPPAPPA-- 168
XP_015788909 170 -------------------------------------------llmianqqpmqqqpylfpspTSSSSRDFQSVGPHSpg 206
XP_015790456 161 ---------------------------------------------------kqlnkpllsiatNSH--SSSITPFKPTlp 187
XP_015781488 165 --------------------------------------------------nlmmnksmlsmssNAP--HSYLNPVPPTaa 192
XP_001967001 258 ------------PPSNRLQ----------------------QSPSIgi------gHHPSFRsdfnvnlrQQP-------- 289
AAI62002     152 ------------PESLAAAaaaaqqlqv--------------------arkqdtrqtATFR--------QQP-------- 183
XP_002113013 161 ------------PPTAIDTvtplqav---------paenqdEEPVI-----------QQFK--------QQA-------- 192
EGT59635     157 ------------G-GGLPSpfpninfkhlfqpmfleqlggfPANPAaqqfrhpphVAAAMQqhqr-vtdHQS-------- 214
1_pfamImport 133 ------------S-GGLPSpfpnfnfkqlfqpmfleqlggaFPSTPptqfrppphMAAAMQhhqlkvtdHQS-------- 191
CAP23824     161 ------------STGGLPSpfpnfnfkqlfqpmfleqlggfGQNPPpaqfrppphMAAAMQhqqmrstdHQS-------- 220
EGT59638     169 --------------------------------------------MVpdvprvpsdIPAFLQsllncaqqQQPgpgnmssi 204
XP_015788909 207 mgmsslmnphhgPPSGLMSsgsssnl------------------------versqnrSSFC--------QQP-------- 246
XP_015790456 188 s--------iplRPGLLQGpssahssvts--gvssisvserQAPPA------------AFR--------QQP-------- 229
XP_015781488 193 rtf-----kqnlTGSRINPisgpashqfs--atpsnsiserQGPPA-------------FR--------QQP-------- 236
XP_001967001 290 ----------PP-------MKSCLSCHQQIHRNAPICPLCKAKSRSRNPKKPKKK 327
AAI62002     184 ----------PP-------MKACLSCHQQIHRNAPICPLCKAKSRSRNPKKPKRK 221
XP_002113013 193 ----------PP-------MKMCLSCHQQIHRNAPICPLCKAKSRSRHPKKKRKi 230
EGT59635     215 ----------PP-------MKQCQSCYQQIHRNAPICPMCKCKSKSKNPKKPKRK 252
1_pfamImport 192 ----------PP-------MKTCQSCFQQIHRNAPICPMCKSKSRSKNPKKPKRK 229
CAP23824     221 ----------PP-------MKTCQSCFQQIHRNAPICPMCKSKSRSKNPKKPKRK 258
EGT59638     205 prnmmnrhrmPPsfveaskMKVCENCGANIHRNAPTCPVCKMKTRSKNPKKKIRR 259
XP_015788909 247 ----------PP-------MKSCLTCFQQIHRNAPICPNCKAKSRSRNPKKPKRK 284
XP_015790456 230 ----------PP-------MKSCLSCHQQIHRNAPICPLCKAKSRSRNPKKPKRK 267
XP_015781488 237 ----------PP-------MKSCLSCQQQIHRNAPICPLCKAKSRSRNPKKPKRK 274
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