Conserved Protein Domain Family
PIG-U

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pfam06728: PIG-U 
GPI transamidase subunit PIG-U
Many eukaryotic proteins are anchored to the cell surface via glycosylphosphatidylinositol (GPI), which is posttranslationally attached to the carboxyl-terminus by GPI transamidase. The mammalian GPI transamidase is a complex of at least four subunits, GPI8, GAA1, PIG-S, and PIG-T. PIG-U is thought to represent a fifth subunit in this complex and may be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
Statistics
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PSSM-Id: 429085
Aligned: 51 rows
Threshold Bit Score: 171.256
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002291238  71 LTQLLGRGILPSiRaavldpIHTWSHLEEacfwkdnapslwmdvavahSTVGNSADA-SDdVVRKAKGGySAIYTPGTrI 149
Q22672        31 SAAIAVRAVCASyS------DLFEERVEL-------------------TSVVYSFEKlKD-SIAMVDDG-LNPFEAKN-M 82  Caenorhabditis ...
XP_002639921  27 SAAIAVRAASFAyS------DYFEERVEF-------------------TSTVYSFERvKD-GIAMLDDG-LDPFETKN-M 78 
A0DGJ7         1 MYRIILILKCLLwYfgk-wdVDLTWLPYF-------------------SNPYTQYSNiRE-AKYLIANN-YNPYNTDG-I 57  Paramecium tetr...
ETW34786     127 LELYFQKNKRYN-NlrsfllKNDYMHYLF-------------------NTDIYNLKYlYDsYVLRILKK--DMYSSLV-I 183
CAQ41297      95 LQEYFQRNKRNG-KikqfllKNDSMHYSF-------------------NSDLYNLKYiYEsDILGRLSA--DVYSSLT-V 151
ESS28069      75 aVGVALRLFLYSvg----ltLSESTEPLV-------------------SPASASFSSfRE-ALTLHALS-FSPYTGGV-Y 128
Q5CYY5        10 IISILIKLSF---FilvehdLEDYTNGFF-------------------GILGQNFGEvLE-FCALKEYG-ISTYYESKrV 65  Cryptosporidium...
Q16H22         9 LLGAALRYLL---Mhsh-ygVTIQNRVEV-------------------ATPLNSWKRaIE-GAYLYANG-TNPYEGDL-Y 62  yellow fever mo...
XP_001843669   8 FVGALVRYLL---Msse-ysGLIRGRVEV-------------------ATPLNSWKRaVE-GAYLYANG-TNPYDGDL-Y 61 
XP_002291238 150 VSPPLVVAFLGETlvcps-----------ihinTTLLWVI-------------QQLLLLAADGIGALCIYHIgkriceme 205
Q22672        83 HFPPLTLHLFRFL--------------------LNTAPTM-------------ILPLFISIDVATTWILSSA-------- 121 Caenorhabditis ...
XP_002639921  79 HFLPLTLYVVRYL--------------------LKTSPVL-------------LAPLWILLDISTAWIAAQS-------- 117
A0DGJ7        58 FQKPLIVYGLNLI--------------------------D-------------NDIIFLIADILVCFLIVQL-------- 90  Paramecium tetr...
ETW34786     184 RINPIFLKILHFLlfkpikinidvlikicnnyeFR------------------FFLFICIIDILIAIFLFLIidkln--- 242
CAQ41297     152 RINPLLLKALQFVlfreipiksgitkgnrngrsGEGATSRgvepfslnrpelrFFLLICAVDLLIGVLLFLItqrla--- 228
ESS28069     129 RQQPLVFLSLKWLtgagrg--------adescnTSSCQWR-------------YYLVLIFIDLVAATALAVAaaeartwa 187
Q5CYY5        66 NFPAVFMELISGLcss---------------inSKNGLIF-------------PFLAINLIQILQGILIYSYli------ 111 Cryptosporidium...
Q16H22        63 HQNPFVLVSVWFLmekl---------------------------------fafASAIFINLEVGTILMLKSVaaifirkl 109 yellow fever mo...
XP_001843669  62 HQNPFILVSLWYLmqka---------------------------------aayVGMVFIQLEIGTAFMLKAAatvfirel 108
XP_002291238 206 ekse-------egeierqttsskNtlgerstdlmvpeilrpergwvfglaykvllsdESLGILEKRPEkqktdkaansng 278
Q22672       122 -----------------------A---------------------------------DVVWRQTHGSS------------ 133 Caenorhabditis ...
XP_002639921 118 -----------------------A---------------------------------QKVWKSVHGRDd----------- 130
A0DGJ7        91 -----------------------F---------------------------------GAKQGYRMS-------------- 100 Paramecium tetr...
ETW34786     243 -----------------------------------------------------nwntyFLYIISNNYTtph--------- 260
CAQ41297     229 -----------------------------------------------------rwevyFRYVNEDTRDaqw--------- 246
ESS28069     188 vswrqkdwenstdvtrekgpserG---------------------------------KTLAKGseeshqqp--------- 225
Q5CYY5       112 ----------------------kS---------------------------------YPILSTISKTIiekn-------- 128 Cryptosporidium...
Q16H22       110 y-------------------------------------------------dnqrsrlsSFAKGTKELQispd-------- 132 yellow fever mo...
XP_001843669 109 y-------------------------------------------------ekqrrrrdSFAKDTEELQieta-------- 131
XP_002291238 279 nssyvtndhyqqiltlqLVPLVASIVYFSNPISMIANATGSLRSLWDALLLLSLYYATlPpttltkeg------apikrp 352
Q22672       134 -----------------SIRKLIFSLYAFNPITIVSTGILSLTVIQNFVSAVILLSLVtDr------------------- 177 Caenorhabditis ...
XP_002639921 131 ----------------rNIGKLVFSLYAYNPIAIISTGILSLTVVQNFVFAAIFFFLVsDr------------------- 175
A0DGJ7       101 ----------------------ISLFYHLNPITFANLILKNTNVFDHIFLLLTILSALkM-------------------- 138 Paramecium tetr...
ETW34786     261 --------------fniINPLLLINIYLNNPINILANSFLSLDNFKLLIITANFYLTLsRiqnvsnqqkqnvyknkykri 326
CAQ41297     247 ---------------nlIDPILLMNIYLNNPLTILSNSFLSFDNFKLLLITTSFYLTLrRirseasp-----------pq 300
ESS28069     226 ---------rdgveeivATPALVAASYFLHPMTIGAILSLTIHTLPLAFFASALACAT-Ragw----------------l 279
Q5CYY5       129 --------------nyeLCVNMLVGIFWINPISIYTSSLLSFGIEFELFLQLLLLWISiDssh----------------k 178 Cryptosporidium...
Q16H22       133 --------------dvrSVPYYVALAYMFNPYSILNCVGQTTTVLSNFLLALFLLGMA-Nr------------------- 178 yellow fever mo...
XP_001843669 132 --------------dlgNLPYYVGLAYLFNPYSILNCVGQTTTVASNFLLALFLVGTA-Yr------------------- 177
XP_002291238 353 sASKSALSLALATY-VDLAYAVFLLPILlwrgs----------------------------------lsekPSQVNQHHD 397
Q22672       178 -PTICAILIGAWSS-FTIYPFILISCLV-------------------------------------------FRSNGSIVK 212 Caenorhabditis ...
XP_002639921 176 -PAVCALLIGAWSS-FTIFPFILISCLA-------------------------------------------FRANGSLFK 210
A0DGJ7       139 -KILSPILFGILLY-LNPQYFIVLAAISvifr------------------------------------rdsSKTSKFAFK 180 Paramecium tetr...
ETW34786     327 cSFFNLLLILFHNA-ILLYITSFHFILVviginnfiiyie--------------------edflkryhikqNVQFCKLAH 385
CAQ41297     301 sstpNLIAILFVNA-MLLYITSFHFILVligvnhlliyih--------------------qgimykyklkvPLNFLHMLL 359
ESS28069     280 sRWLSVVFFGFSLY-VGPPQALLLALPLahllhavrtqt---------------------vqrldllevlpSPKKDILPG 337
Q5CYY5       179 fRALLPIISGINVYySPTVSISLIPSTLtlflsgnqhflkfntcpqlfdnfkmhfkhfwinflsnyfnfrnIL------K 252 Cryptosporidium...
Q16H22       179 vRLVACMALALETQ-INIYPCVLIIPAAlfi---------------------------------------aqDDKHKMQS 218 yellow fever mo...
XP_001843669 178 sRIVAGVALALETQ-MNIYPCVLVVPAAlfi--------------------------------------aeSTPRNKWLS 218
XP_002291238 398 WKT---VLVLFLSYLGGLHLlASALvGGDw----NEYkqvMLQTVLPNVSFVeqdSSGSvpgPCMGLHWYFFVQMFDRFQ 470
Q22672       213 FLS---LVLVSALTTITFVG-INYLlNNQ-----SLN---FLGPVYASILNF---SSIQ---PNSGLYWYFFVQIFEHFR 274 Caenorhabditis ...
XP_002639921 211 FLS---LVALSIFSATTFFA-LNFLlNGN-----SLN---FVEPTYTSILKF---TSIQ---PNVGLYWYFFVQIFEHFR 272
A0DGJ7       181 LII---FLLVSIATICLLLY-NSYK-ITG-----DWQ---FIEKTYIDYYFP---KDHK---PTIGFLWALFSGLFSKYK 241 Paramecium tetr...
ETW34786     386 MLFknmFLLLITLIIYALFIvISYFqNSH-----SLS---FLNNTVINEYKI---LLLL---PNLGNFWYIFSTMFRDYY 451
CAQ41297     360 ILLqnlALLIATLALYALLLlASAYvNSG-----SFS---FLNNTLINEYKV---LFLL---PNLGNYWYLFSTTFRDYY 425
ESS28069     338 LLRg-tLLFFAGLAFCVLLHvASYFaLRAyt-adAAD---YLDSTVVSMWGV---RDLG---PNLGIFWYIFSLIFERYR 406
Q5CYY5       253 IIL---FFTSFTITFLSLHI-FSFIiINHqnshhILTfkeYFYTFIVQNFTLlenKDLN---PYLNIYWFLMYCIASEFR 325 Cryptosporidium...
Q16H22       219 ILI---TCGMFLMTFLFVNY-ASFM-IMG-----DWS---FLDATYGFIFNC---RDLQ---PNIGLFWYFFTEMFDHFR 279 yellow fever mo...
XP_001843669 219 IGT---TCGTFLGAFLWFNY-AGFV-IMG-----DWS---FLDATYGFILNC---RDLQ---PNIGLFWYFFTEMFDHFR 279
XP_002291238 471 PYFVVLINGIP-AMFPIPLVIRLHRY-----PAVLVATFQLLWSIFR--PTTTVHTLALALILALLSPRsLVRMGN-PS- 540
Q22672       275 SFYTMSFVVLY-FFMPIPITFLIRKD-----TILHFTIIGFLVSIFF--PYPTLNQVSLLLAFLPVHDV-YKKHFRyTI- 344 Caenorhabditis ...
XP_002639921 273 SFYTNSFVILY-FFMPIPITIMIRRD-----PVLHFTIIGLLVSIFF--PYPTLNQVSFVLAILPLLEE-YKKHFRyTL- 342
A0DGJ7       242 SLYHAFFMLLP-ACYILPLYNLFVKYakrekEYLGFMIGVSLFCSFLyfQYIAISDLIIIFILLFQR----YDWLFnSLp 316 Paramecium tetr...
ETW34786     452 YSFLFLFHFHI-FLYPVPLFFRLVKT-----PLIYLKVLIAIALVFQ--PNITINDIVYSLLLLVID----YERTIyAIp 519
CAQ41297     426 HSFLFLFHFHV-FFYPLPLLFRLVKT-----PLIYLKIMISIALVFH--PNITVNDIVFSLLLLVID----YKRTVyAIp 493
ESS28069     407 LLFVMIFQGHC-FILVVPLFVRMFRY-----PLAYCQVVIAIALLFQ--PSFCISDSAFLVSLLISRWH-IVER-KvAF- 475
Q5CYY5       326 LYFQIILGSCL-IIYAFILNISLEKI-----PFKALQSQLLLCFVFK--SNPTFINYLLIFFFILFDSVt-LFESKsGFl 396 Cryptosporidium...
Q16H22       280 TLFLYTFQINAtLLYLFPLTFKLHKE-----PIMLLTMLLALGVVFR--PYPCVGDIGMYLSLLPLWKS-ISKFMGhNY- 350 yellow fever mo...
XP_001843669 280 TLFLYTFQINAtLLYLFPLTFKLHKE-----PVMLMTILLALGVVFR--PYPCVGDVAMYLSLLPLWKS-ISKFMGhNF- 350
XP_002291238 541 -LISfFALPVTVILFVTFHRMWLVTGNGNPNY-IFFQCLAY 579
Q22672       345 -LIA-GTIVSTVFLMPVMWHMWIVSSSGNANF-FFGTTIVY 382 Caenorhabditis elegans
XP_002639921 343 -LIG-GAIITTIALMPVMWHMWMVSSSGNANF-FFGATIVY 380
A0DGJ7       317 tIVIvHAGCLILFLGGGLQLTWTHSFTGNPNFtFFQVFVSY 357 Paramecium tetraurelia
ETW34786     520 fIKLlLILLSNLCLCFVTLNLWLRKNTGNANYvFFNQLVVF 560
CAQ41297     494 fIKLiIIMLGNLGLFFVTTNLWLRKNTGNANYvFFNQLIVF 534
ESS28069     476 -VKLiVVAFVAVSIYPVTTELWLGRNTGNPNF-VYNIQIIF 514
Q5CYY5       397 aSFSfVTWMICIPSAFLIRPIWILENSLDSNF-YYFLTLAG 436 Cryptosporidium parvum
Q16H22       351 -IVG-ATMLVTSILGPTVWHLWIYSNSANANF-YFGMTLVF 388 yellow fever mosquito
XP_001843669 351 -IVG-ATMLVTSILGPAVWYLWIYANSANANF-YFGMTLVY 388
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