Conserved Protein Domain Family
TC1
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pfam15063: TC1 
Thyroid cancer protein 1
Thyroid cancer protein 1 (TC1) is thought to decrease in apoptosis and increase cell proliferation. It is found to be expressed in thyroid papillary carcinoma. This suggests its importance in thyroid cancer. The molecular mechanism of TC1, involves up-regulating cell signalling through ERK-1/2 signalling pathway and it positively regulates transition between the G1 and S phase in the cell cycle. It is thought to positively regulate Wnt/beta-catenin signalling pathway by interacting with its repressor. In humans, it is located in the chromosomal position, C8orf4. This family of proteins is found in eukaryotes and contains a conserved NIF sequence motif.
Links
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Statistics
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PSSM-Id: 464478
Aligned: 8 rows
Threshold Bit Score: 94.4558
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_007238793   4 YASSESRRVTPRVHGSGFDTARRKRAAPHIFEQVREDALVRLFRKAGDAKAEERARSVFaaaASHEPGETARALMALH 81 
XP_015201894   5 AAPAAAAPASPSQLWRLSGRRSRKAASPDIFRGVHLRQLQRLFRRSGDQQAEQRAQLVW---GRSDAAGLAQALTRLR 79 
XP_003433652   1 MGTPASVVSEPPLWQAPAEARGRKQASANIFQDAELLQIQGLFQRSGDQLAEERAQIIW---ECAGDHRVAEALRRLR 75 
AAI61303       8 AAMSVSLRVSPSVHGYHFDTASRKAATANIFQGVDQDSLQRLFKKSGDKKAEARARIIFc--IDQDSEEKARALQALR 83 
XP_001232955  10 SAMSTSLRVSPSVHGYRFDTALRKKAVANIFESVDEESLQKLFKHSGDKKAEERAKIILd--TDQDVEEKARALMALK 85 
XP_014325207   6 ASASPSVVASPSSLWRLAERRNRKSGSGNIFSTVNLWQLQRLFRAAGDEDAEQRAQLVW---GHRDEAELAKALVALR 80 
XP_022619439  15 ASPPSSMVAGPSSLWRLAERRSRKAGSGNIFSDVNLWQLQRLFKAAGDQDAEQRAQLVW---GHGDEAELAQALIGLR 89  greater amberjack
XP_016383802   4 YASSNSRRVSPAVSGVKFDTAHRKKASPNIFENVNQDVLVKLFEKAGDLKAVERARSILa--LHQDPEGISKALMALQ 79  Sinocyclocheilus ...
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