1RH7,1RGX


Conserved Protein Domain Family
Resistin
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pfam06954: Resistin 
Resistin
This family consists of several mammalian resistin proteins. Resistin is a 12.5-kDa cysteine-rich secreted polypeptide first reported from rodent adipocytes. It belongs to a multigene family termed RELMs or FIZZ proteins. Plasma resistin levels are significantly increased in both genetically susceptible and high-fat-diet-induced obese mice. Immunoneutralization of resistin improves hyperglycemia and insulin resistance in high-fat-diet-induced obese mice, while administration of recombinant resistin impairs glucose tolerance and insulin action in normal mice. It has been demonstrated that increases in circulating resistin levels markedly stimulate glucose production in the presence of fixed physiological insulin levels, whereas insulin suppressed resistin expression. It has been suggested that resistin could be a link between obesity and type 2 diabetes.
Links
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Statistics
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PSSM-Id: 462049
Aligned: 28 rows
Threshold Bit Score: 91.6208
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1RH7_D         1 CSFESLVDQRIKEALSRQE------PKT--------ISCTSVTSSGRLASCPAGMVVTGCACGYGCGSWDIRNG-NTCHC 65  house mouse
EDO41771      26 GEDETALEGTAVEDEEPVSdpeaivSRKwhlwrkgrLHCLSVSSKGNTAACPAGYLVTGCACGYACGSWNPEANgTRCFC 105
XP_016846768  25 CSIDRAIDAKIKAAVDSKvsa-tlaKSQ--------LTCTTIKTSGALAACLHGYTVTGCSCGKACGSWDVRDN-STCHC 94 
XP_008102434  23 CPVEDAIDAKISAAIDSKvs---ilVPE--------LSCTSVSARGADVSCPSDYKATGCACGMACGSWDIRGE-TQCHC 90 
XP_007656086  24 WILDTDVIEKIQERVNSLvss-alkDLS--------LVCTSVFTQGALVACPSGYKATACSCGSACGSWDIRSD-TVCHC 93 
XP_003803468  22 CPMDEAVNKKLQEHTSSLisg-slsKMS--------LDCQTVTSRGNLATCPAGFTISSCTCGSACGSWDVRAE-TTCHC 91 
NP_001186158  24 CPVDDAINEKIKDGTSSLfls-gtrSLN--------LECRTVTSRGALATCPGGYSVTSCTCGSACGSWDVRAE-TTCHC 93 
XP_005332174  22 CPMDEAVDEKIQGGISSLifa-amqNIR--------LDCKTLTSRGNLATCPAGHAVTACTCGSACGSWDVRAE-TTCHC 91 
Q6QR67        22 CPVDEAINEKIRDVASFLipq-virNIG--------LECRSVTSRGDLVTCPSGFAVTGCTCGSACGSWDVRAE-TTCHC 91  pig
XP_004008606  22 CPIDKAVSKKIQDVTTSLlpe-avrNIG--------LDCQSVTSRGSLVTCPSGFAVTSCTCGSACGSGAGRAE-TTCHC 91 

1RH7_D        66 Q--C----SVMDWASARCCRM 80  house mouse
EDO41771     106 HkgCmpngQSLDWTLAMCCKV 126
XP_016846768  95 Q--C----ANVDWTAARCCKI 109
XP_008102434  91 Q--C----ANIDWTSARCCKV 105
XP_007656086  94 Q--C----RGIDWTSARCCQI 108
XP_003803468  92 Q--C----AGMDWTGARCCRL 106
NP_001186158  94 Q--C----AGMDWTGARCCRI 108
XP_005332174  92 Q--C----AGMDWTGARCCRV 106
Q6QR67        92 Q--C----AGIDWTGARCCRL 106 pig
XP_004008606  92 Q--C----AGMDWTGARCCRL 106
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