2IAG,3B98,3B6H,3B99


Conserved Protein Domain Family
PGIS_CYP8A1

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cd20634: PGIS_CYP8A1 
Click on image for an interactive view with Cn3D
prostacyclin Synthase, also called cytochrome P450 family 8, subfamily A, polypeptide 1
Prostacyclin synthase, also called prostaglandin I2 synthase (PGIS) or cytochrome P450 8a1 (CYP8A1), catalyzes the isomerization of prostaglandin H2 to prostacyclin (or prostaglandin I2), a potent mediator of vasodilation and anti-platelet aggregation. It belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410727
Aligned: 8 rows
Threshold Bit Score: 747.739
Created: 8-Sep-2017
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
heme bindingchemical
Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:
  • Structure:3B98: Danio rerio prostacyclin synthase binds heme; contacts at 4A
  • Structure:3B6H: Human prostacyclin synthase binds heme; contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                             #      #   
2IAG_A        30 SFLTRMKEKHGDIFTILvggRYVTVLLdPHSYDAVVWEprtrlDFHAYAIFLMERIFDvqlphysPSDEKARMKLTLLhr 109 human
3B98_A        42 KFLTRMKEKHGDIFTVRaagLYITVLLdSNCYDAVLSDva-slDQTSYAQVLMKRIFNmilpshnPESEKKRAEMHFQga 120 zebrafish
3B6H_A        42 SFLTRMKEKHGDIFTILvggRYVTVLLdPHSYDAVVWEprtrlDFHAYAIFLMERIFDvqlphysPSDEKARMKLTLLhr 121 human
3B99_A        42 KFLTRMKEKHGDIFTVRaagLYITVLLdSNCYDAVLSDva-slDQTSYAQVLMKRIFNmilpshnPESEKKRAEMHFQga 120 zebrafish
CAG06955      51 KFLARMKEKHGDVFTVRvagQYVTVVLdANSFDSVVNDtv-slDFISSKNQLLERIFHlklpglqPAAEREWMERYFQgc 129 Tetraodon nigro...
XP_007909553  53 TFLLKMKRKHGDIFTVQmagRFVTVLLdPHSYDSVLWEstaklDFAAYSRLLMDRIFDvqlpnydPHKEKNMMKTQLQge 132 elephant shark
EMP35753     159 SFLSQMKQKHGDIFTIQvagKYITILLdPHSYDSVLWEsscqlDFSKYARLLMDRMFDvklpdydPTEEKVMLRSALQnk 238 green sea turtle
XP_018090395  55 KFISKMKEKHGDIFTIQvagKFITILLdPHSYDAVVWApsshlDFGKYARMLMDRMFDvrlpptgVTEEKTLLTSHFQss 134 African clawed ...
Feature 1                                                         #                              
2IAG_A       110 elQALTEAMYTNLHAVLLGDAteags-gwhemGLLDFSYSFLLRAGYLTLYGiealprthes-qaqdrvhsadVFHTFRQ 187 human
3B98_A       121 slTQLSNSMQNNLRLLMTPSEmglktsewkkdGLFNLCYSLLFKTGYLTVFGaennns----------aaltqIYEEFRR 190 zebrafish
3B6H_A       122 elQALTEAMYTNLHAVLLGDAteags-gwhemGLLDFSYSFLLRAGYLTLYGiealprthes-qaqdrvhsadVFHTFRQ 199 human
3B99_A       121 slTQLSNSMQNNLRLLMTPSEmglktsewkkdGLFNLCYSLLFKTGYLTVFGaennns----------aaltqIYEEFRR 190 zebrafish
CAG06955     130 rfAKLCQTMKANIESLLLGEVqgssasewkqdSLFSFCYSLLFRAGYLTMFEstgn--------------anvVYEEFRK 195 Tetraodon nigro...
XP_007909553 133 nlSTLTQAMSSNLQNVLLSEAkgttk-twmkeGLFNFCYNILFRAGYLTLFGnerehsnketsknkdrihsetVYHEYRR 211 elephant shark
EMP35753     239 nlPSLTKAMFFNLQTLLLSDPsnlsr-qwtdeGLFHLSYSMMLRAGYLTLYGneeenyndpscqnkdrahsaeVYNEFYK 317 green sea turtle
XP_018090395 135 nlTILTKSMFHNLNIILLNDRwlpdt-ewkdqGLFEFVYGVMLRAGYLTLFGtesepdtatcsavrdlerskeIYHEFRK 213 African clawed ...
Feature 1                                                                                 ##  ## 
2IAG_A       188 LDRLLPKLArgslsvgdkdHMCSVKSRLWKLLSPARLARrahrSKWLESYLLHLEEmgvsEEMQARALVLQLWATQGNMG 267 human
3B98_A       191 FDKLLPKLArttvnkeekqIASAAREKLWKWLTPSGLDRkpreQSWLGSYVKQLQDegidAEMQRRAMLLQLWVTQGNAG 270 zebrafish
3B6H_A       200 LDRLLPKLArgslsvgdkdHMCSVKSRLWKLLSPARLARrahrSKWLESYLLHLEEmgvsEEMQARALVLQLWATQGNMG 279 human
3B99_A       191 FDKLLPKLArttvnkeekqIASAAREKLWKWLTPSGLDRkpreQSWLGSYVKQLQDegidAEMQRRAMLLQLWVTQGNAG 270 zebrafish
CAG06955     196 FDQLLPKLAqgslkkeesqTVNSSRERLWKLGSADWLSQgsgpLSWQQSYLRFLHEegvgAEMQKRASLLQLWTTQCNNG 275 Tetraodon nigro...
XP_007909553 212 LDQLLIKLAystlsadekkEAASVKKRLWSLLSGENLNGklnrSNWLEGYRNHLQDlelqDDMLARAMVLQIWATQGNIG 291 elephant shark
EMP35753     318 LDQLLMSAArstltaaekkEAASLKRHLWKLLSVKRLNSkankSLWLESYKLHLEElgvdEDMQSRAMLMQLWATQGNAG 397 green sea turtle
XP_018090395 214 LDQLLMKSArntlspgekeEAALVKSRLQQLLSMKSHKGkcckSSWFEYYQQHLEEieatEDMQSRALVLQLWATQGNAG 293 African clawed ...
Feature 1         #                                                            #     #           
2IAG_A       268 PAAFWLLLFLLKNPEALAAVRGELesilwqaeqpvs---qtttlpqkvldSTPVLDSVLSESLRLTAaPFITREVVVDLA 344 human
3B98_A       271 PAAFWVMGYLLTHPEALRAVREEIqggkhlr-------------leerqkNTPVFDSVLWETLRLTAaALITRDVTQDKK 337 zebrafish
3B6H_A       280 PAAFWLLLFLLKNPEALAAVRGELesilwqaeqpvs---qtttlpqkvldSTPVLDSVLSESLRLTAaPFITREVVVDLA 356 human
3B99_A       271 PAAFWVMGYLLTHPEALRAVREEIqggkhlr-------------leerqkNTPVFDSVLWETLRLTAaALITRDVTQDKK 337 zebrafish
CAG06955     276 PAVFWLLAFLLTHPEAMEALKSEIrrlnlqdpsgh-----hltsnslelyHTPVFDSILSETLRLTAaVLIKRVVVEDKV 350 Tetraodon nigro...
XP_007909553 292 PATFWLLAFLLKHPEAMTAVLDEInrngklhgnkiqfnnplltisqdlldNTPVFDSILNEILRLTAaPYISREILQNMT 371 elephant shark
EMP35753     398 PAVFWLLLFLLKHPAAMAAVQGEVekiirnrgqtmk---qmqgisqemldSTPVFDSVLNETLRLTAaPFISREVLADMN 474 green sea turtle
XP_018090395 294 PATFWLVLYLLKHPEAMAAVQGEFqrifprnrqekr---hieemnqdlldKMIILDNVLSETLRLTAaPFISREVLTDMS 370 African clawed ...
Feature 1                                                                          ###   # ###  #
2IAG_A       345 MPMadGREFNLRRGDRLLLFPFLSPqrDPEIYTDPEVFKYNRFLNpdgseKKDFYKDGKrlKNYNMPWGAGHNHCLGRSY 424 human
3B98_A       338 ICLsnGQEYHLRRGDRLCVFPFISPqmDPQIHQQPEMFQFDRFLNadrteKKDFFKNGArvKYPSVPWGTEDNLCPGRHF 417 zebrafish
3B6H_A       357 MPMadGREFNLRRGDRLLLFPFLSPqrDPEIYTDPEVFKYNRFLNpdgseKKDFYKDGKrlKNYNMPWGAGHNHCLGRSY 436 human
3B99_A       338 ICLsnGQEYHLRRGDRLCVFPFISPqmDPQIHQQPEMFQFDRFLNadrteKKDFFKNGArvKYPSVPWGTEDNLCPGRHF 417 zebrafish
CAG06955     351 LQMasGQRYKLRRGDKVILFPWLSPqmDPEIHPEPQSFKFDRFLNndrsvKDKFYKNERrlKYYTMPWGAGRHACIGKEF 430 Tetraodon nigro...
XP_007909553 372 LRLadSREYNLRKGDRLCLFPYLSPqmDPEIYEEPEKFKYDRFLNadgteKKNFFKNGKqlKYYNMPWGGGGNVCIARVY 451 elephant shark
EMP35753     475 LRLadGRKFSLRKEDRLCLFPYLSPqmDSEIYEEPEKFKYDRFLNadnteKKDFYKGGErlKYYNMPWGAGINTCIGKFH 554 green sea turtle
XP_018090395 371 LKLadGQQYQLRRGDRLCLFPFVSPqmDPEVHQQPQVFQYNRFLKsdgtaKTEFYKNGRrlKYYNLPWGAGSNVCVGKKH 450 African clawed ...
Feature 1        #   #                                 #        
2IAG_A       425 AVNSIKQFVFLVLVHLDlelinADVEIPEFDlsryGFGLMQPEHDVP 471 human
3B98_A       418 AVHAIKELVFTILTRFDvelcdKNATVPLVDpsryGFGILQPAGDLE 464 zebrafish
3B6H_A       437 AVNSIKQFVFLVLVHLDlelinADVEIPEFDlsryGFGLMQPEHDVP 483 human
3B99_A       418 AVHAIKELVFTILTRFDvelcdKNATVPLVDpsryGFGILQPAGDLE 464 zebrafish
CAG06955     431 AIATIKQFVFFILTHFDvkklePQAQLPPVNpsryGFGMLQPDGDLQ 477 Tetraodon nigroviridis
XP_007909553 452 AINSIKLFVFMMLSQFDfqladPEARIPVFDtsryGFGLMQPEHDII 498 elephant shark
EMP35753     555 AVNSIKQFVFILLTNFDlelkdPEARIPGYDkgryGFGMLQPKNDIM 601 green sea turtle
XP_018090395 451 AINSIKQFVCLLLFYFDfelknPAEEIPEFDrtryGFGLLQPERDII 497 African clawed frog

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