Conserved Protein Domain Family
XRCC2
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cd19490: XRCC2 
XRCC2 recombinase
XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells 2) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC2, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC3, helps recruit RAD51 to the break site.
Links
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Statistics
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PSSM-Id: 410898
Aligned: 28 rows
Threshold Bit Score: 143.642
Created: 16-May-2012
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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ATP binding
Feature 1:ATP binding site [chemical binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  ######                                         #                      
CAA70065      41 GDILEFHGPeGTGKTEMLYHLTARCILPkseg--------------gleVEVLFIDTDYHFDMLRLvtilehrlsq---- 102  human
XP_002111793  38 GDVVEFYGSeGCGKTEMLLHLMIKCIMPdnfrgi---------amngrsMSVVYIDCDYHFNLLRLmsileqryckacqg 108  Trichoplax adh...
EFA84255      84 GGVIEINGSsGTGKSECALHIVVQSILPnnwpiyesnsnsselvfggneIGVVYFDNDYKFDLERLrsiillkfnhcltn 163  Polysphondyliu...
XP_001630414  30 GDVVEFYGKeGCGKTEMLLHLAANCIMPrswhel---------ylggkgVSVIFIDTDYHFQILRLiaimeyrta----- 95   starlet sea an...
XP_002733158  38 GNIIELFGKgGCGKTEILLHWIANCILPvkwqgi---------elggcnIDVLFIDNDWHFSILRLvnvieccinhkirn 108  Saccoglossus k...
XP_001237167  38 GELIEISGDsNSGKSLLCLELIARIILPtscg--------------gleLGAVLIDCENSYSKTVLlsilekhilnhaep 103  Anopheles gamb...
NP_001152815  38 SDVIEIKGTiTSGMRCLLTKLIAKFILPskyd--------------gldVDVLFINTENQFQISHLfnflqqeisniq-- 101  jewel wasp
XP_001849499  39 GELVELTGKtNCGKSVLMLELIARIILPvehg--------------ghgVGAVFVNCDNNVHMLRLldimekqivnnssp 104  southern house...
EGB09390     728 GEIVELYGEpQTGKSELLYRCAATWALPasrg--------------ggaRRVVLFDTEHKFQLPRLravvaavaaafpaa 793  Aureococcus an...
EGI65175      36 KSIIEITGAsSTGKTVLLCQFIAKCILPaqykei---------kidgcdACAILINTLGHVQMSKIaelmtsmvrnayqv 106  Panamanian lea...

Feature 1                                                                                        
CAA70065     103 -------------------------------------------sseeiikycLGRFFLVYCSsSTHLLLTLYSLESMfcs 139  human
XP_002111793 109 s------------------------------------natmvkhseefirkcLERFYIIRCDtIHQLITSLHLLEYSiss 152  Trichoplax adh...
EFA84255     164 kqhqiaekiklqkdkdssstpdelfiqqldindssssssacyilfeklfnecLSRLYIYKCKdSVQFISTLNALPHLiks 243  Polysphondyliu...
XP_001630414  96 -------------------------------------------esetlikqcLTRLFIVRCNsSVELLATLLSMEQLiic 132  starlet sea an...
XP_002733158 109 hlt---------------------------------nensvsvdvesiikfsLQHLYVERCHdSLEFLISLEMLETLlgn 155  Saccoglossus k...
XP_001237167 104 ala---------------------------------stltdphlletiqraaLSRLHLITCYsLEQFEFSLLALPVLfvr 150  Anopheles gamb...
NP_001152815 102 ----------------------------------------gpinvdqlvreiLNSLKIINCYtHNQLLLTLHSLDNLllq 141  jewel wasp
XP_001849499 105 ag-----------------------------------rnmgreeirrireesFTRLTMIKCCtMDEFEFTLLSLNDVflk 149  southern house...
EGB09390     794 ---------------------------------------ddaepaaaaadaaLGRILIAPCGtTLDFLCQLELVEQRae- 833  Aureococcus an...
EGI65175     107 an-----------------------------------vqpsaetidyiinqsLENLTVINCCnNDQLLLILHTLENEfvs 151  Panamanian lea...

Feature 1                           #                                                    #       
CAA70065     140 ----------hpSLCLLILDSLSAFYWIDrvngges---vnlqestLRKCSQCLEKLVNd---yRLVLFATTQTimqkas 203  human
XP_002111793 153 ----------npDIGIMLIDGIGSFYWQDkfss----------ssgVDQLCKIVKYLCDe---hNLIVLATKSAirkqfe 209  Trichoplax adh...
EFA84255     244 vgkevrdgsakrEIQLVVIDSVSSFYWLDkqgesl------gsrlgQLVGLDLFHQIISq---yQLTVIGIKQSifkegt 314  Polysphondyliu...
XP_001630414 133 ----------kpEICVMMIDSLSAFYWVDrssgges---lqdqqenIRKTTSVLSRFSRe---nHLVIFTTVHAifgnnt 196  starlet sea an...
XP_002733158 156 ----------kpNIAVIMVDSISAFYWMDrnnf---------netkVEHLMGVLQKVVNd---yQIVAFLTNSWtnvnhk 213  Saccoglossus k...
XP_001237167 151 ----------qpELTFVLIDSIATFYWTKctaknl-----irqdtyQKAHCKTLSRLAGk---wKKIVLFTKPShfggrq 212  Anopheles gamb...
NP_001152815 142 ----------nkKVGVIVIDSISTYYWQQkndls--------ynsfIMKILNNIRKVTId---fKVLTIYTKQFnfesk- 199  jewel wasp
XP_001849499 150 ----------hpAASFLLIDSLVAFYWNKcteknl-----irmdtyLKSLCVRLEKLCKe---lQLVAIFTRPSyfgtgr 211  southern house...
EGB09390     834 ----------seEAPLLLVDSIGAFLFTEdrpadrklaapslthaaVRAIARLLARRRAtlvaaKPAYYEAKAGdprgd- 902  Aureococcus an...
EGI65175     152 ----------nkRITLLAIDNILAYYWQArkenll------tmnyyAISLLKIIRSQTSq---fHTVTVYTRWDgpvpky 212  Panamanian lea...

Feature 1                                                           #
CAA70065     204 ssseepsha------------srrlcdvdidyrpyLCKAWQQLVKHRMFFSK 243  human
XP_002111793 210 nsrlanksrlr-------ndiasnynsthskhmeyMPNVWRKLVKYRYILSK 254  Trichoplax adhaerens
EFA84255     315 nttpnfnnn-----------nnhqitkpplpkndfLGPQWSRLVKYRIKLET 355  Polysphondylium pallidum PN500
XP_001630414 197 ke--------------------------mmrnqdyLCKAWQQSVKYRYMFTK 222  starlet sea anemone
XP_002733158 214 dvpqmed---------------avdtpkfsnkfdpIYRVWQKLATQSYHMWK 250  Saccoglossus kowalevskii
XP_001237167 213 asgrdfeansaagalsldgstqassfagqltpsmsTASSAVSLIDHRIELTE 264  Anopheles gambiae str. PEST
NP_001152815 200 -------------------------------klstEQHEGKKIVRYEINMYK 220  jewel wasp
XP_001849499 212 estsdglfegsq-----sgavaavlaastsafgsgGGANWKQVVKHRIELAE 258  southern house mosquito
EGB09390     903 ------------------------------yhpeyLPRAWTALVRRRVCLSR 924  Aureococcus anophagefferens
EGI65175     213 -----------------------------esyaecTDTLERTGVNYRLQLSK 235  Panamanian leafcutter ant

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