Conserved Protein Domain Family
FAM60A

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pfam15396: FAM60A 
Protein Family FAM60A
This protein family, FAM60A is a family of proteins is found in eukaryotes. It is known to be a cell cycle protein that binds to the promoter of a gene transcription repressor complex, named SIN4-HDAC complex. This means that FAM60A has an important role to play in 'switching on' gene expression. Proteins in this family are typically between 179 and 324 amino acids in length.
Statistics
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PSSM-Id: 464703
Aligned: 19 rows
Threshold Bit Score: 223.797
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDV99927       2 FNFHKPRVYRSADGCCICRAKSSSSRFTASRKYEKESTLCFNLQE--PRNGEICNACVLLVKRYKRLPVGSKRHWGHVVD 79 
ACQ58576       2 FGFHKSKIYRSNDGCCICKTKSSSSRFTDSSRYEETFGLCFGLSE--DRVGDICNACVLLVKRWKKLPNGSKKNWNHVVD 79 
XP_014340329   2 FGFHKSKIYRSLEGCCICKTKSSSSRFTDSRRYEESFRLCFGLLE--QRTGDICNACVLLVKRWKKLPVGSKKNWSHVVD 79 
XP_001627810   2 FPSHRPKIFRSRLGCCICKAKSSSSRFTSSAKYEHHFEGCFALTE--KRQGEICNACVLLVKRWSKLPPGTEKNWKHVKL 79 
EKC25990       2 FSFHKPKIYRSINGCCICRAKSSSSRFTDSKRYECEFEKCFRIRE--KRAGEICNACVLLVKRWKKLPEGTSRHWHHVVD 79 
EEC04885       2 FSFHKPKIYRSALGCCICRAKSSSSRFTDSKKYEPEFARCFRIVEedRRSGEICNACVLLVKRWKKLPPGTTRDWHHVVD 81 
XP_015781913   2 FSFHKPKIYRSISGCCICKAKSSSSRFTDSKKYEAEFEKCFRISE--KRSGEICNACVLLVKRWKKLPPGTARNWRHVVD 79 
1_pfamImport   1 FSFHKPKVYRSSTGCCICKAKSSSSRFTDSKKYEDDFVECFQLPE--KRCGEVCNACVLLVKRWKKLPEGNSRNWRHVVD 78 
EFA00368       2 FSFHRPKVYRSSTGCCICKAKSSSSRFTDSKKYEEDFMKCFKLAE--PRQGEICNACVLLVKRWKKLPAGSDRNWKHVVD 79 
XP_019697865   2 FNFHKPKVYRSATGCCICKAKSSSSRFTDSKKYEDDFLECFQLQE--RRTGEICNACVLLVKRWKKLPAGSNRNWRHVVD 79 
EDV99927      80 AR-AGPGTK----SLAKQKKRdseieaksgggggsgsgSFIPEKFAKIFKKNRKGKITAVAAPPTvdseq----qqqrSS 150
ACQ58576      80 AR-AGPGFKm--tKPKKIKNS-----------------------DGKRKSKLKKLHKLKRQNSDA-------------HS 120
XP_014340329  80 AR--GPGFKv--tKLKKIKSI----------------------SDKRRKIKPKILQKLRRQNSDA-------------HS 120
XP_001627810  80 STiTKGSLEkeekSIRDFKNR---------------------NDFRKKLSLNHE------------------------IS 114
EKC25990      80 AR-AGPGIK----SSMKIKNNk----------------SPSSSKYKSPLKSKKMYAHS--------------------IP 118
EEC04885      82 AR-AGPGTK----CVNKGKVK-------------------PPKRPLKKHRRRHRLGADKRCKMDIgggalsddvtgrwAP 137
XP_015781913  80 AR-AGPGTK----SMKYAKLNhsn------------ssPLTSSTNAKKHQKPKKLKSSLIDFSDIqgd-------nfhVP 135
1_pfamImport  79 AR-AGPGTK----SMTKFKSRnhnrp--------kpkrKSIDDDSEEIIRKKK-------------------------PR 120
EFA00368      80 AR-AGPGMK----SMSKFKSKn----------------KKIDENCDKIKKKKHF-------------------------- 112
XP_019697865  80 AR-AGPGIK----SLTKYKSRnkk------------kvKDKPEKIEKIVKKKYVYSK---------------------TE 121
EDV99927     151 SSHESSPH-----------------------------LSDSNESYDDEQQqqqqqqqtgvcavvtpyqtrkrtaaaaqla 201
ACQ58576     121 TTSSVSPAqsp------------------------sySNQSDDGSDIESK------------------------------ 146
XP_014340329 121 TTSSASPSqsp------------------------cySNHSDEGSDTEAQ------------------------------ 146
XP_001627810 115 EEYANSNSssn------------------------nnNNNSNNKDVTQVT------------------------------ 140
EKC25990     119 SSIYDMSVned------------------------scDKDEFEGSDSEESeve--------------------------- 147
EEC04885     138 PCLMPKPRdg---------------------------------------------------------------------- 147
XP_015781913 136 SRRIPSPIqsd------------------------ssDLDGDSDEDDYLSdlddegkeqgaegafnspkkklr------- 184
1_pfamImport 121 KLRDSSPCediqvsees-----------pegsrsptpSEDNDDAPVKRLT------------------------------ 159
EFA00368     113 -EREYSPLsdnedvdmtevdflcedgpsggssrtaspRDSDSEENVVKNR------------------------------ 161
XP_019697865 122 ADREHSPAmsdelteyysiae----vgsksssrsespADSDDIAE----------------------------------- 162
EDV99927     202 sacknkngssssssvaqrrlkltgsKRRRMLE-PQKHRRSIDNVPFFEEHDLLRLQVCCGIVFQSLslgSACYIIDPELY 280
ACQ58576     147 -----------------------------------QRRPTPSIFSFLDRSYWKRQKVCCGIVYKGR---FGEVIIDPRLF 188
XP_014340329 147 -----------------------------------KSRSTAPVLSFLDPTYWKRQKICCGIIYKGR---FGEVIINPQLF 188
XP_001627810 141 -------------------------STGCQTSfLFPTLSSSTKLPYIDLSLWRREEICCGTIFRGP---HGEVLVDPKLL 192
EKC25990     148 -----------------------esQENCQRK-NKRKQSDPRISPFLDLSYWKKTEVCCGTIFKGL---NGEVLVDPQLL 200
EEC04885     148 ----------------------------yLLG-RRAKSAPFRISSFLDMSFWRKEKVCCGIIFKGP---HGEVLIYPKLL 195
XP_015781913 185 ---ssskspisngllspssssstsrRNLAKRT-KPPTSSLSKVSSFLDMSFWRKEKICCGIIFKGP---NNELLIYPKLL 257
1_pfamImport 160 --------------------------------------PLPPAPSFVDLSIWRRQKICCGTIFVGP---MGAVIVDPRLI 198
EFA00368     162 -------------------------RHKGQAK-RRDGSSLPDLSDFICPEYWKREAICCGTIFRGM---CGEIIVDNRFL 212
XP_019697865 163 -------------------------KQIDVPPvENMEVEQSYINDFIDLSYFKREIICCGTIFKGP---YGEVIVDPSLL 214
EDV99927     281 KP-CDKH 286
ACQ58576     189 KP-CCSS 194
XP_014340329 189 KP-CCSV 194
XP_001627810 193 KPlC--- 196
EKC25990     201 HP-CYTC 206
EEC04885     196 RP-CRCR 201
XP_015781913 258 KP-CSCR 263
1_pfamImport 199 TP-CRRR 204
EFA00368     213 KA-CSAR 218
XP_019697865 215 KP-CVGC 220
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