Conserved Protein Domain Family
DUF4704

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pfam15787: DUF4704 
Neurobeachin/BDCP, DUF4704 alpha solenoid region
This domain of unknown function is found in eukaryotes on neurobeachin and BEACH domain-containing proteins (BDCPs). Mutations in this proteins are associated with Lipopolysaccharide-responsive and beige-like anchor (LRBA) deficiency. According to structure prediction is adopts an alpha-helical solenoid structure.
Statistics
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PSSM-Id: 464870
Aligned: 18 rows
Threshold Bit Score: 385.1
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ERN14372     1301 TADKHCCEATVMAGTQLCSRRLFQHIIYCVGGVSVFFPLLNQFDSITEKSKSEQEecsmlkSILRERLAAEVIELIASVL 1380
EKC35427      450 PHFVHVQHALMSGEVKSVITHSIYSTLHSLGGVQVVFPLFGQLDMPVSK----GDni---pSEVDYTICAKLMSILCNLM 522 
EEN65155      360 SFFVHSPHALMLADVRAIVTQSIHSALHSIGGIQVLFPLFAQLDHVQQN----GE--------LDYSVCSMLLGLLSDLL 427 
XP_004345297  507 WFSAESSGAILLNGSRTVVTHSYHHALESIGGIQTLFPLVSQFDHADQPRD--GAlg--ivYEPDPAYSLTLLSLFAETL 582 
EFJ20988      568 QSDAVSHEATIMSGTQLCYRCLVQNNIHCVGGITVFFPLLTRFRHAGKDFDGSVT-------DADDYYLADVIELLTAVA 640 
XP_015693681 1265 GADRSTFEAKIIGGTKLCSRHLPQDIIYCVGGVSVFFPLFNQFRDTVTDGEQSSHa-----SLINYKLPAEVIELVASVL 1339
XP_002886711  692 LQERLAFEADIMVGTQLCSRRLLQQIIYCVGGISVFFPLITQSDRCESEALKEETs----aMPLKERMTAEVIELIASVL 767 
EFC50489     1373 DIHQAMLNSRILNGTQLCVTHNAKDIIGCLGGIKVLFPLFLQMDRLSHTDQVISE-------KADPFLVNTLFSLIIDLL 1445
EFA75292     1545 NIGGDRNYDATLVAINPCVSRDIKDIIYCLGGIKVLFPLIPQLNQTLADPQLDST--------SSSKLTIQVLGLFKDML 1616
XP_018673008  440 RWFVHNPHALMLPDVKAVVTHSIHSALHSVGGAEVLFPLFSQLNYKQKD----GS--------VDTSVCSTLLTFLLQLL 507 
ERN14372     1381 DDNLANQQQMHLLSGFSILGFLLQSVPPRQLTLETVSALKRMLTVVGNSg-----mSKILLPDSISRIFLNAHIWIYTDY 1455
EKC35427      523 ESSVTIQQQMMQNRGFLVIGYLLEKANRQHVTPEVLEIFLRLTQYLVALp-----tGSVILKHLFDHILFNPALWIHASV 597 
EEN65155      428 QSSVRTQQQMIQAKGFLVIGYLLEKATRKHITIQVLDSFLQLAKYLASLp-----tGGPLLRNLLDHILFNPTIWIYTPA 502 
XP_004345297  583 AASTTSQSQLDQHRGFTVLAHLLDDVLPTNMSRQVLEVLLQLAQSLRKAaetnslaAQSLFRDLFDQVLFRFNLWICSDV 662 
EFJ20988      641 TKNYVNQKVLHSTGGLGLLGYLLQFVSIKQLSVKVITALNNLLCVLSETadn--alSDLLVRETVLKVYLNPSAWIYAPY 718 
XP_015693681 1340 DGNVSNQQQMYLLSGLSIMGFLLQSATPKLLNIETLSALKYMFDVLRNCg-----mSKVLLKDAILQIYLNPQIWVHSSY 1414
XP_002886711  768 DENPANQQQMHLLSGFPILGFLLQSIQPKQLNLETLSSLKHLFNVISSSg-----fAEQLVEDAISSIFLNPHIWLHAAY 842 
EFC50489     1446 SAHNDNLEDMARCRGFLVISFLLKQISPQHLTRNTVALIPSLLSCAKD--------HSVLYSDIVNYLVFNFRLWIYTDV 1517
EFA75292     1617 RGSEANQEEMLRCNGLAVLSYLLQTIPPENLTLGALNIFKDMSNQI----------SEPSLVEEVYSLLLDFRLWIKTRF 1686
XP_018673008  508 QGSVKTQQQVLHGKGFLVIGTLLERAHKDHITMDVLNTIISMAKFLDELa-----tGSALMRQFCDYILFNPALWIHTKP 582 
ERN14372     1456 VVQRELYMFLVQYFDKDSHLLTSLCRLP---RIIDIIRQFYWDKS-------------------------------KGRS 1501
EKC35427      598 EVQTKLYCYLATEFINNAQIYNNIRRVSavlQTMHTLKLYYWVVNp------------------------------SDRS 647 
EEN65155      503 KVQMALYTYLATEFVQSANIYNNIRRVStvlQLMHTLKHFYWVVNp------------------------------QDRS 552 
XP_004345297  663 AVQKRLLGVLASDLVRTESV--NVRSLIgvqRLMDLISNFFWLPDpataaaaaaisatteppasraepapdnedetQSPT 740 
EFJ20988      719 VIQRELFLSLINFLENRK--YDNVCGVS---RFLDMLHQFYWD---------------------------------KPKH 760 
XP_015693681 1415 EVQRDLYTFLLKYFETDGRFLPLLCGLP---RIIDIVCQYYSEGV-------------------------------DSRF 1460
XP_002886711  843 NVQRELYMFLIQQLDNDPRLLGSLCRLP---RVIDIVWNFYWESEry---------------------------ckGSKP 892 
EFC50489     1518 EVQKLLFQQLLDISNEKKDNFTKIREILgvqKLLDLMRWFYWYERa------------------------------KSNS 1567
EFA75292     1687 EVQKSLMVMIKQIIFDK---HDQVKDIItvqVMLDIMANFYWYEFa------------------------------ESSA 1733
XP_018673008  583 VVQVALYTYLATEFVSSPTIQTNLRRVStvlLLIHALKHYYWVENp------------------------------LPRS 632 
ERN14372     1502 AFGSKPLLHpvtg-----eiigMRPSRQEVQKLRLLLLSLAEMTLRQH-------------------------ISASDVK 1551
EKC35427      648 GVVPKGTDG-------------PRPNYDEIVKLRSFMLMYLKQLLMKGp-----------------------gVQEDELQ 691 
EEN65155      553 GIAPKGMDG-------------PRPTQNEVKSLRAFMLLFMKQLILKDq-----------------------gVDEDELQ 596 
XP_004345297  741 GAARYQLAGqpvlhpvtkravaQRPNTSDIVELRMIVLTIIKQLVLDGs-----------------------gITADELS 797 
EFJ20988      761 RKMSKTVGTr------------DRPRQEELSQLRILILSLAETAIRNH-------------------------MSLSDAK 803 
XP_015693681 1461 GVGSKSLLHpvtk-----qavgDRPKIEEICKLRLLLLSLAERSLKLQ-------------------------VSLADIR 1510
XP_002886711  893 LMHPARTIE-------------ERPSRDEIHKIRLLLLSLGEMSLRQN-------------------------ISSGDVK 934 
EFC50489     1568 TESEYQLGTekicnpatgavlgQRPSQENIYEIRQKLTKLLKCLTSKSaeivivnnderlttttgtvlttatsISYPELE 1647
EFA75292     1734 ILTSKDILQ-------------KRPNQSDITDLRQVIFEIIRQLLRNP--------------------------TTSDVA 1774
XP_018673008  633 GVVPKGLDG-------------PRPSKDEILSLRAFILLFLKQLVSRTg-----------------------sILEDELQ 676 
ERN14372     1552 SLIAFF---EKSEDMVCIEDVLHMIIRATSQKSllTSFLE-QVSLHGGYQIFLNLLHRDLEPVRLQGLQFLGKLLVGLPL 1627
EKC35427      692 SILNYL---STLHEDDNLMDVLKLSVELMAEHP--MSMVP-SFDKKGGIRTVFKLLASPSEELRIQSLKLLGYWLMRSTH 765 
EEN65155      597 AILNYL---LTMHEDENLHDILQLLVALMSEHP--SSMIP-AFDKRNGVRVIFKLLASASEGIRVQALKVMGYFLKNTNA 670 
XP_004345297  798 AILNYIvanLSINQEWHVIDAVELILTLMCDHP--EPILG-LFEQQNGIQVALSLLSAKSVPVRGFGLKILGKLLSWLPT 874 
EFJ20988      804 SLISFI---DRNDDLICVEEVLQMLLGLLGEPIflSSFLE-CVHSLGGIHIFLNLLSRRQEVIRLLALHVLGSLFLAIPV 879 
XP_015693681 1511 ALASFF---GRNQDITCVEDMLKMIIRALSESSvlTSFLE-HTDSLGGCCIFINLLKREFEPIRLLGLEFVGKLLAGVPS 1586
XP_002886711  935 ALTAFF---ETCQDVACIEDVLHMVIRAISQTSvlVSFLE-QVNLIGGCHIFVDLLQRDYEPIRLLSLQFLGRLLYDVPS 1010
EFC50489     1648 AIINLL---ADCNDNMQYSDVVIFVLELLLSPD--GVVIAdMLANMKAYQVFVQLLYTHHEPTRLNILKCIGQMLILNPK 1722
EFA75292     1775 AIARYT---IYTMDKTQVIEMIEFLIDLLSKSSf-QQFFD-ELEKIGSTDIFLTLMSNKDEAVRGAALQLISKLHLTSHA 1849
XP_018673008  677 SILGYL---LTMHEDENILDVLQLLVAMVSEQG--GAVTP-VFDRRNGIVVIFKLLGSRSENVRVHALKLLAYFLKNLSL 750 
ERN14372     1628 EKKGprlfnlavgrskslsesnrrVNPGSQTLFS-AISDRLFMFP--PTDSLYATLFDVLLGGASPK----QVLQKHNQP 1700
EKC35427      766 KRKS--------------------EALGPHNLFS-LIGERLMLNEstITMPIYNVLFELLTERMTPE----TCTKKHNEP 820 
EEN65155      671 KRKN--------------------ELMQAHSLFT-LLGDRLMLHTdtLSMTTYNALYEILTEQVCTQ----VLHVPHPEP 725 
XP_004345297  875 KRAD--------------------KLIQQHQLFS-LISTTLSMYSteLDKTTYNALFEIMLNQVTKQ----LVPDRFVSR 929 
EFJ20988      880 ERKSiwlfgigg-----nkgqgdtVISRQKDLVWsIIKERLLQFP--FTDSLRVTLFDLLLGAAIPK----QVRENDFET 948 
XP_015693681 1587 EKKVaklftlpigqsspifdnsrkEITAASHLFFyTISERLFKFP--LSYNLSAAFFNVLLGGTSPN----KEYSQSDQS 1660
XP_002886711 1011 ERKGpkffnlavgrtkslsqghkkIGARTQPIFL-AMSDRLFQYP--QTDNLRATLFDVLLGGASPK----QVLQKHNQV 1083
EFC50489     1723 LRQR--------------------VFAETSYGFS-TITNILTIFN--ITIQTYGVLRDIFLGCISLNqrdiLEFDGFEQT 1779
EFA75292     1850 NNQTvsnnk----------ltlkkKVKSIFQDSI-IIARSLHLFP--LTEYTYRYLMAFALGFNVEPvnfnITMTLEDLM 1916
XP_018673008  751 KRKN--------------------EVMESQSLFM-LVGERLLLYSdeFSLTAYNAMYEVLVEEPSTQ----VLQKTHAEP 805 
ERN14372     1701 EKQknkknshndtgSHFVIPQILVLIFKFLSCCKDIST----REKILSDLLDLLETNHSNIEALMENA-WSSWLLTSASL 1775
EKC35427      821 ESS-----------FRIENSAVLKVVATMIRQSKVGPVvmevKRCFLSDLTILCNNNRDNRRTVLQMSvWQDWLFSQAYI 889 
EEN65155      726 DSS-----------CRVHNPMIMQVVARLIKNSRATEKvlevKKLFLSDMIKLFNNSRENRRTLLQCSvWQDWMFSLCYI 794 
XP_004345297  930 DAT-----------SRIAHPGVLRTLFDLVTHDSSSAGtttlFRL-LGDLVMLLSHEPDNRRIFLAFPnWQNWFVTFLKS 997 
EFJ20988      949 SISagnpa-htatfPEFFLPQVLGVLLKFVEASDDWTS----RQDVLKDILALIQTNPANCGVLLQEPgWQDWLFAVFSS 1023
XP_015693681 1661 KNKdcss----shlASFFLPQILVCIFRYLHSCQDSSA----RIRILSDLLGLLDSNPTNIEALMEHS-WNYWLETSTKL 1731
XP_002886711 1084 DKHrsk-----psnSHFFLPQIFVFIFEFLSGCKDGLA----RMKIISDILDLLDSNPMNVEALMEFG-WSAWLTASMKL 1153
EFC50489     1780 EQS-----------YKVQ--AVLQPIFRLLVNTQPn-----vKHHILQNFKIVLKSNRA-KDCLLQQVgWQEWLLNIICV 1840
EFA75292     1917 ADH-----------VNIVFPEIIGAILKLLPTAESii----lRQLILQNIKVLMGNNAANRTSLLQIDkWPEHLFSVLND 1981
XP_018673008  806 SAN-----------TLIGNPVMMKVIATILRQCSSSHTme-lKVTFLNDLLVLFQMSRDNRRILLQQSvWQDWMLELGHL 873 
ERN14372     1776 EVI--------------------------------------------------------------------------RNY 1781
EKC35427      890 YPR--------------------------------------------------------------------------TEE 895 
EEN65155      795 HPA--------------------------------------------------------------------------NKD 800 
XP_004345297  998 VTRvqdcgfsahhlvnpaaahssvlvvsgnrqsaapasarpasptpppadpssssdaslpptptppgaaaaaqsfsgSAA 1077
EFJ20988     1024 ASS--------------------------------------------------------------------------RKQ 1029
XP_015693681 1732 DVL--------------------------------------------------------------------------KNY 1737
XP_002886711 1154 DVI--------------------------------------------------------------------------KDY 1159
EFC50489     1841 SGI--------------------------------------------------------------------------SDA 1846
EFA75292     1982 AEI--------------------------------------------------------------------------KND 1987
XP_018673008  874 RPN--------------------------------------------------------------------------TVQ 879 
ERN14372     1782 KtktqvqvanskISEEILVRKLYVVVLFHNLCLVKGGWQQ----------LEETWTFLVL 1831
EKC35427      896 E-----------QKITDMVMSLFRMLLHHAIKYEFGGWRV----------WIDTLAILHS 934 
EEN65155      801 E-----------QKVTEMVYSLFRMLLYHAMKYEYGGWRV----------WVDTLAIAHS 839 
XP_004345297 1078 PaaivasaaqenLQCAELICTLFRVLLCHALKNEREGYQV----------WVDTIAVFKH 1127
EFJ20988     1030 Kedqd---skrwADEVLLIRKIFCALQVHAVFNTKGGWRQvermtvyvlkYTEQVCCSHK 1086
XP_015693681 1738 RsvskgeldtveIDEVTLVRNLYALVLAYYLSTVKGGWHQ----------LEDTTNFFLL 1787
XP_002886711 1160 Rselln-hddlaLNEQHFVRGLFCVVLCHYILSVKGGWQQ----------LEETVNFILL 1208
EFC50489     1847 SipsdvgqsaqfELCKDIVIELIAILLYHSLKTVKKGWRD----------IEDTICQVIL 1896
EFA75292     1988 Qq---------ySNVTDLIIDIMKILSIHSL-TEAKGYKT----------LEQILATLRP 2027
XP_018673008  880 E-----------RDCQELIFSIFKVLLYHAIKLEWGGWRV----------WVDTLAIVHA 918 
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