Conserved Protein Domain Family
MAJIN

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pfam15077: MAJIN 
Membrane-anchored junction protein
Membrane-anchored junction protein (MAJIN) is a meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. It is a component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes.
Statistics
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PSSM-Id: 464488
Aligned: 7 rows
Threshold Bit Score: 395.421
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_023601419   1 MSLKPFTYPFPETRFLHSGSSVYKFKIRYGDSIRGEDIENKEVIVQELEDSIRVVLGNLDSLQPFATEHFVVFPYKSKWE 80 
Q9D992         1 MSLKPFTYPFPETRFLHAGPNVYKFKIRYGNSIRGEEIEDKEVIVQELEDSIRAVLANMDSLQPFVTEHFIVFPYKSKWE 80  house mouse
EHB04907       1 MSLKPFTYPFPETRFLHAGPSVYKFKIRYGHSIRTVATLLKSFQIYLFQDSIRAVLENLDNLQPFVTEHFIVFPYKSKWE 80 
1_pfamImport   1 MSLKPFTYPFPETRFLHAGPNVYKFKIRYGNSIRGEEVENKEVIVRELEDSIRVVLGNLDNLQPFTTEHFIIFPYKSKWE 80 
XP_014969318   1 MSLKPFTYPFPETRFLHAGPNVYKFKIRYGNSIRGEEIENKEVIIQELEDSIRVVLGNLDNLQPFATEHFIVFPYKSKWE 80 
XP_025860284   1 MSLKPFTYPFPETRFLHAGPNVYKFKIRYGNNIRGEEIEDKEVIVQELEDSIRVVLGNLDNLQPFATEHFIIFPYKSKWE 80  red fox
XP_013006196   1 MSLKPFTYPFPETRFLHAGPSVYKFKIRYGHSVRAEEITDKEVIIQELEDSIRAVLGNLDNLQPFITEHFIVFPYKSKWE 80  domestic guinea...
XP_023601419  81 RVSHLKFKHGEIVLIPYPFVLTLYVELKWFNENLSTGKPIDDSPLGLVPAERKAARAMKK--KRKRMELSVSPSRPGL-- 156
Q9D992        81 RVSHLKFKHGESILTPYPFVFTLYIEMKWFAEDLPSGKPADDIPLELVLAETEAEEATMRkwKRKLMEEPSSPSRQGP-- 158 house mouse
EHB04907      81 RVSHLKFKHEDVVLIPYPFVFTLYVEMKWFHENLSPGRPINDSPLGLVVVEKKAAGASKKq-KRKLVEQHSSPGGARQ-- 157
1_pfamImport  81 RVSHLKFKHGEVVLVPYPFVFTLYVEMKWFHENLSPGKLINDSPLGLVSAEKKSAEAMMR--KRRHTEVPSSPRKSGRff 158
XP_014969318  81 RVSHLKFKHGEIILIPYPFVFTLYVEMKWFHENLSPGKPISDSPLGLVPAEKKAVGAVMR--KRKHMDEPSSPSRPGL-- 156
XP_025860284  81 SISHLKFKHGEIVLVPYPFVFTLYVEMKWFHESLSPGKPIKDSPLGLVLAERKAAGA--R--KRKRVEVLSSPSRPGL-- 154 red fox
XP_013006196  81 RVSHLKFKHEEVVLIPYPFVFTLYVEMKWFHENLPPGKPINDSPLGSAVAEKKAAGDAGK--KRKLVEEHGSPRGTAL-- 156 domestic guinea...
XP_023601419 157 --DRAKMRTSSQGPSKKKFLMETSRNMERNTQQKCQETPAFDGTDVQEQGSRWEDNLAGEITPPVQQSNPPPPAGPtdlG 234
Q9D992       159 --HRAKMETSSEASSNKKPLKESKRSTDEEAQQEYQDTPASNAIAVKEQDAALGHGLQGLVVPPLQHSSPPPPKEP---G 233 house mouse
EHB04907     158 --PRDKMRSSSQRPSTKKPPMGTRRNRERKPQQERQKTVASDTTDVQEQHSKWGHNLPGAIVPPLQQNNSPPPKEL---G 232
1_pfamImport 159 phLRAKVETSSEAPSKKKPPMETRRTWNDNEQQE---TPAFDATDVQEQGPKWGDSLAGQMAPSLQWNNPPPPKGPkelG 235
XP_014969318 157 --DRT---------GKEKPNKDCRRLWPLISLVSRNKILSG-GTACQ-----------GQLSHPCSTTH-LHLRSE---Q 209
XP_025860284 155 --DRA------------KIGISSQSPSKKKPLMETRRILSQ-RTAHQ-----------GRSSPHCSKTIHFHLKDPqswQ 208 red fox
XP_013006196 157 --PRAKMGSPSRRARSKKPPMETTRnrkktqqetwkt-vtsdttdvqtqdSKRGHNLPGAMVPALQQSSSPPPQEP---G 230 domestic guinea...
XP_023601419 235 TSGFFGF 241
Q9D992       234 ARGFLGF 240 house mouse
EHB04907     233 IRSFFGF 239
1_pfamImport 236 TTGFFGF 242
XP_014969318 210 PAASLGF 216
XP_025860284 209 LVASLGF 215 red fox
XP_013006196 231 TRSFFGF 237 domestic guinea pig
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