1PK1,1PK3


Conserved Protein Domain Family
SAM_Scm

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cd09578: SAM_Scm 
Click on image for an interactive view with Cn3D
SAM domain of Scm proteins of Polycomb group
SAM (sterile alpha motif) domain of Scm (Sex comb on midleg) subfamily of Polycomb group is a protein-protein interaction domain. Proteins of this subfamily are transcriptional repressors associated with PRC1 complex. This group includes invertebrate Scm protein and chordate Scm homolog 1 and Scm-like 1, 2, 3 proteins. Most have a SAM domain, two MBT repeats, and a DUF3588 domain, except Scm-like 4 proteins which do not have MBT repeats. Originally the Scm protein was described in Drosophila as a regulator required for proper spatial expression of homeotic genes. It plays a major role during early embryogenesis. SAM domains of Scm proteins can interact with each other, forming homooligomers, as well as with SAM domains of other proteins, in particular with SAM domains of Ph (polyhomeotic) proteins, forming heterooligomers. Homooligomers are similar to the ones formed by SAM Pointed domains of the TEL proteins. Such SAM/SAM oligomers apparently play a role in transcriptional repression through polymerization along the chromosome. Mammalian Scmh1 protein is known be indispensible member of PRC1 complex; it plays a regulatory role for the complex during meiotic prophase of male sperm cells, and is particularly involved in regulation of chromatin modification at the XY chromatin domain of the pachytene spermatocytes.
Statistics
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PSSM-Id: 188977
Aligned: 13 rows
Threshold Bit Score: 112.129
Created: 5-Mar-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
oligomeroligomer
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:oligomer interface ML [polypeptide binding site]
Evidence:
  • Structure:1PK3, Drosophila, SAM domain homooligomer of Scm protein, contacts at 4A.
  • Comment:SAM domains of Scm proteins can form head-to-tail homooligomers via interactions between the mid-loop (ML) and end-helix (EH) surfaces.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                        ##### ##  ##  ## ####                   
1PK1_B        11 RSQPIDWTIEEVIQYIESNDN-SLAVHGDLFRKHEIDGKALLRLNSERMMKYMGLKLGPALKICNLVNKVNG 81  fruit fly
1PK3_B        11 RSQPIDWTIEEVIQYIESNDN-SLAVHGDLFRKHEIDGKALLRLNSEMMMKYMGLKLGPALKICNLVNKVNG 81  fruit fly
Q9UQR0       625 SKDPSTWSVDEVIQFMKHTDPqISGPLADLFRQHEIDGKALFLLKSDVMMKYMGLKLGPALKLCYYIEKLKE 696 human
B0FZN9       252 TKHPSTWSVEAVVLFLKQTDPvALCPLVDLFRSHEIDGKALLLLTSDVLLKHLGVKLGTAVKLCYYIDRLKQ 323 Bornean orangutan
Q8N228       340 SRNPSAWTVEDVVWFVKDADPqALGPHVELFRKHEIDGNALLLLKSDMVMKYLGLKLGPALKLCYHIDKLKQ 411 human
Q9UN30       252 TKHPSTWSVEAVVLFLKQTDPlALCPLVDLFRSHEIDGKALLLLTSDVLLKHLGVKLGTAVKLCYYIDRLKQ 323 human
XP_426184    332 SKNPLTWTVDDVIWFVKDADPhALGPHVELFRKHEIDGNALLLLKSDMIMKYLGLKLGPALKLCYHIDKLKQ 403 chicken
CAX14812     299 SKDPSRWSVDEVVWFIKDADPqALGPHVELFRKHEIDGDALLLLKSDMIMKYLGLKLGPALKLCYHIDKLKQ 370 zebrafish
NP_001089967 627 GKDPAMWSVDDVMRFVKEADPqSLAPHAELFRRHEIDGTALLLLKSDMIMKYMGLKLGPALKLCYHIERLKQ 698 African clawed frog
XP_002435493 582 SAHPLEWSIEDVIRHISSLDA-ALASHSDLFRRHEIDGRALLLLNSDMMMKYMGLKLGPALKICNIIDKIKG 652 black-legged tick
NP_001071811 633 SRNPTKWSVNDVVSYIGEREP-ALQPHLHLFNKHEIDGAALLLLNNNNIVKFMSLKLGPTLKLCSLVEGLKE 703 Ciona intestinalis
Q96GD3       587 GRDPSSWTVEDVMQFVREADP-QLGPHADLFRKHEIDGKALLLLRSDMMMKYMGLKLGPALKLSYHIDRLKQ 657 human
XP_002197012 631 NKDPSTWSIEEVVHFVKEADPrALAPHAELFRRHEIDGKALLLLRSDMIMKYMGLKLGPALKLCYHIERLKQ 702 Taeniopygia guttata

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