Conserved Protein Domain Family
MINDY-3_4_CD

?
pfam13898: MINDY-3_4_CD 
Deubiquitinating enzyme MINDY-3/4, conserved domain
Deubiquitinating enzymes (DUBs) remove ubiquitin (Ub) from Ub-conjugated substrates to regulate the functional outcome of ubiquitination. This entry includes MINDY-3/4. They belong to the MINDY (motif interacting with Ub-containing novel DUB) family (peptidase family C121), whose members are deubiquitinating enzymes releasing Lys48-linked ubiquitin. This is a conserved domain found in deubiquitinating enzymes, MINDY-3 and MINDY-4.
Statistics
?
PSSM-Id: 464029
Aligned: 35 rows
Threshold Bit Score: 376.571
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_016842780  55 RMLVFGSCASPP-KAEWART--GLTLRAVgQNLSFGLRAPRNST----RGLITAVQAIMLKHFLFKLTkqETRCSPDVL- 126
XP_002107678  75 RKILFGQLMVPK-EIDWCRE--SFIFHIHnYGLPFGLKIHKNGP----CGVIAVVQAFVLRHLIFDE---DDENNYKRL- 143
EFX82046      23 RQVVFGQCPASV-RPEFFNQgpGLVFREHgHPLAYGLSITNPSTlpmmRAILMTIQAQILRTLLFDSAilKLPKTCNPL- 100
XP_019882367  73 RTLVFGSCASPP-KIEWTRT--GLTLRPYgQSLAFGLRTPRNTT----RGLVTAVQAIMLKHFLFKCNrqDLRVEPETL- 144
EEB10908      71 RRIVFGSSTIPP-KSEWLKM--GFNYHNSnKEFSYGLKIVRNTT----SGLFSVVQAYLIKYFLFNKKk-NRNVVPEQL- 141
XP_001851429  12 RQTVFGSAASPP-RGEWTRT--GINYGAAsGEYPYGLRTPRNAT----RGMQSVLQAFIIKYFIFDCKprDKSVVMEEL- 83 
9_pfamImport   1 RTVCFGSAAAPPtRPEWTKT--SFIFGTPnEGNPYGLRCPRNAC----RGLIAVVQGFLVKNFLFDRRarSSLSTPEES- 73 
XP_001951036 108 RLTVFGACDTPP-RGEWLRT--GFVFRDPeKELSYGLRARRNGT----RGMQTAIQGYILKHLLFTSTn-------NSC- 172
4_pfamImport   1 RTVVFGTAVAPP-RGEWLRT--GIIMHEEeKEVPYLLKGPKNTT----RGLLTVLQAEILKYLLFEVSinLFIIVQNLL- 72 
XP_025753849  81 RRILLGGNFRVF-DYEWRRA--IFHFREPnSELAYALKadgGGA----QAIQMVVQARIIKHLLFAR---QSSSDGRTLh 150 Nile tilapia
XP_016842780 127 --LKPSYE------------KQVVVLTASIAEIIWRCAGGFavqnasasfnsaasslnipK-AVVVLPQET-PYLQ-HSv 189
XP_002107678 144 --KAVNER------------ERQNALALALADILWIAGEES-------------------KtAIVLLPPDDdRSKPiGAs 190
EFX82046     101 --KPTTVT------------IQQEALAYAIANIIWKSGNEQ-------------------S-ATLCLPQPNvVHIV-GSp 145
XP_019882367 145 --LKPSYD------------RQIEVLTSAISEIIWRCAGGFsgsmctn-----vvsntvpK-AVVALPQDT-PYLQ-HSv 202
EEB10908     142 --LKPDKV------------EQVEALWTSLSDLLWIVGEKK-------------------N-CKICLPRSP-PCLQ-SSs 185
XP_001851429  84 --LKPTEA------------EQAQALYLAISDILWNIGEKT-------------------K-ALIVLPGEN-SLIP-HSh 127
9_pfamImport  74 --TKNGKEaiskltssaftpKTNRCIDFGMSEILKQIAEKE-------------------P-IMVVLPGEE-IFVA-HSv 129
XP_001951036 173 --MKPSKQ------------QQLDALCKSITEILWKIGDNE-------------------K-VIVCLPQEK-SYVA-HSl 216
4_pfamImport  73 --I-------------------FCCLFELKSNVMVTANAKImfclfssralskttntqlkK-VILCLPQEN-VYLH-QSl 128
XP_025753849 151 slTEVGRR------------EQDRALAAALSDSLWLAGQEV-------------------S-ATVTLVTEDyCVTP-HL- 196 Nile tilapia
XP_016842780 190 QYFQDGLTETLHLFEFTTL----DDLEIFIKRYLYLFQDEGGpGAKILLYSAILSR---------------GLSKVRNDM 250
XP_002107678 191 QVRLNDMTEDGILYQFNAF----NDLRDFIKKKLPIFQHEFGyGVAFFLYSAILSR---------------GIENIRNDM 251
EFX82046     146 QFNEDGLTEKLQLCQMNRI----EELHHTIRRNIHVFQEDPGpAVMLILYSAILTR---------------GINQVTEDM 206
XP_019882367 203 QYFQDGLTETLHLFEFNSL----EDLEIFIKRYLYLFHDEGGpGAKLLLYSAVLSR---------------GLSKVQNDL 263
EEB10908     186 DYFSDGLTERLHIFDFTTL----EDLRAFLKRYIYVFLEESGpGALLILYSAILTR---------------GISQTSEDM 246
XP_001851429 128 AYFQDNVTEKLFFFEFTKL----DEMQIFMKRYLPYFTENPGpGALLLLYSAVVTR---------------GMENLRNDL 188
9_pfamImport 130 TFFHDSITEKLYVFQMQRP----DDVQFFLQRHISHFSN-----LIHTLYVLPVYRrrrprmyvvaiqccpDKDHIKTDL 200
XP_001951036 217 NYFQDNVTEKLHLFELTNI----QDLEIFLKRYLHLFQDDPGpGSLLLLYSAVLTR---------------GLSKIVSDL 277
4_pfamImport 129 DYFQDGITERIHMFDVESY----DDLEIMIKRYSYLFLDDPGpGAMLLLYSCVASR---------------GPDQVVKDM 189
XP_025753849 197 DYKLDTFTERLQLF----TfsekDAITNFILDHIqcFQEEGShGVILFLYSLICSR---------------TIERLREDL 257 Nile tilapia
XP_016842780 251 EDPRA-----------SILSgcpEEGPLS--LVVLAITGRASPHLHNGVIHVG--DENTYAIPQWGVLVRSEIGFLvheg 315
XP_002107678 252 DDPEK-----------ILLT---ENERCSqeLINLLLVGKAVSYVFNGILDYDykLRKPLQQPLFGIDKRGVVGLL---- 313
EFX82046     207 GKPSGgdgiltpmkslMSINgsiMFGPIS-----LFLLGRASPYLHNGVQYQD--DGDS-RTEETGVLIRSPIGLLlwmg 278
XP_019882367 264 EDPKA-----------SILGgcsEEGPIS--IVVLILTGRVSPHLHNGVVHVG--DENTYAVPQWGVLTRSEVGFLiheg 328
EEB10908     247 KTVGS-----------CFLSg-eDEGLNC--IITLLLTGRATPFLHNGVVYVG--DEDHYAMAQWGIMSRSDIGFLlynd 310
XP_001851429 189 DAPKG-----------AHLMgpyEEGSLN--IVTLMLTGRATPYLHNGVVYVG--DEDHYALPQFGILGRGSIGLLvweg 253
9_pfamImport 201 DNSL------------QYLTgtfEEGSLN--VVTLLLTGRATPHLHNGVIHVG--DEDNYALPQYGILNRCSVGLLiyen 264
XP_001951036 278 MDEKV-----------YLISs-aEEGSIC--IVTLMLTGRATPNLHNGIVNIG--DEQHYAIPHYGILARSEVGLLvhye 341
4_pfamImport 190 DGVKA-----------QLIgp-eEEGSIC--LVTLLITGRATPYLHNGVVYVG--DEDHYATAQFGILARSEIGLLvqmd 253
XP_025753849 258 DSPTS-----------YLLHlspGSSVCRqaLLNLLLTGRASPHLFNGTQHFGq-DGLPLQHPLQGVLSRSDVGYLrwsr 325 Nile tilapia
XP_016842780 316 DTTa-----sKQ----PGSRLKTPSLPIWVTLCLGHHGVLFNTNRELLRNYHAERRFDLQYYTCGGSHAT---LTVDTRA 383
XP_002107678 314 TLMehvaegnYT----VGSKLKTPKYPIWVVNIELSFAVIFSCKRDLLNDWKAERQFHLWYYTGLVSQTElqrIHIDTLQ 389
EFX82046     279 Ne-------aKTaaynVGSRFKTPTVPIWMVVASENSGVLFGEDKGLLRDHQAENRFQLHYHTSTFHQQNpviLKINNRV 351
XP_019882367 329 DVS-------KQ----PGSRLKTPSLPIWVTLCLGHHGVLFNTNRELLRNYHAERRFEVQYFTCGGSHAT---LTVDTRA 394
EEB10908     311 RDDckilnesKQ----PGSRLKTPNFPIWVTFNSGHYGVLFNTNSELLRNYHAERRFELYYYTVEGSCLT---MSVDTRY 383
XP_001851429 254 ENEamr-sasRQ----PGSRLKTPATPVWVSCCCGHYGVLFNSNRELLRNYHAEKRFELHYYTCAGCYIS---MTVDNRQ 325
9_pfamImport 265 EKRvd---qqKQ----PGSRLKTPNLPIWISSCMGYFGVLFNTNGDLLRNYHAESRFELYYYSLSGTQVS---MTIDNST 334
XP_001951036 342 ESSt-----pVQvtqiPGSRLKTPSYPIWITCAKGHYGILFNTNRELLRNHLAERRFPLTHYSCSGSENH---ATVDTRS 413
4_pfamImport 254 TIDa-----dNEcn-iPGSRLKTPSLPVWVVSTCGHYGVMYNTNRELLHNYHAERRFDLTYLTCGGNQCQ---LTVDTRQ 324
XP_025753849 326 EEMerg--alPQ----VGSMLKTPRFPVWVCSINSSCSVLFSATRLLLSDWRAEHLFQLYYYSGQSSQTAtarLTVDTHS 399 Nile tilapia
XP_016842780 384 RenaSGIegs----------------aarETMDIAATP---LEKLIHSKWQDAQVQWNG 423
XP_002107678 390 T---YMP----------------------KNKDNVEPL---INHCIRTKWSGVKISSHS 420
EFX82046     352 Rd--------------------------dSSADAPIPP---LERIIRTKWGDARLDWGN 381
XP_019882367 395 Nq-tSGLsda----------------atmEAADIAATP---LEKLIRSKWQDALIQWNG 433
EEB10908     384 KkfnKEEenn----------------dreKTEDFLSIPlssIEKLIHTKWEDAAIVFKG 426
XP_001851429 326 QedgADDgdgd---------------gerKQSDMVSTP---LERLIHTKWMEAKLTYHG 366
9_pfamImport 335 YhdqAAGmllrapsgsegfstsrrnsdvdDKDESNSSP---LQKLVHTKWQESVVKFHD 390
XP_001951036 414 HqgeQTRimk-----------------atDDINNTTSLlllVECLIHTKWEGASVQWTG 455
4_pfamImport 325 SsgtYMI----------------------HSEETTVTPianIEKLIQTKWPDAQISWHG 361
XP_025753849 400 HhweASSrdg------------------eaDPEKRFPS---LEMTIRTKWDGAAIDWNG 437 Nile tilapia
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap