Conserved Protein Domain Family
Neprosin
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pfam03080: Neprosin 
Neprosin
Pitcher plants are insectivorous and secrete a digestive fluid into the pitcher. This fluid contains a mixture of enzymes including peptidases. One of these is neprosin, characterized from the pitcher plant Nepenthes ventrata. This peptidase is of unknown catalytic type and is unaffected by standard peptidase inhibitors. Unusually, activity is directed towards prolyl bonds, but unlike most peptidase that cleave after proline, there is no restriction on sequence length or position of the proline residue. The peptidase is secreted and is presumed to possess an N-terminal activation peptide. The neprosin domain corresponds to the mature peptidase. It is not known if other proteins with this domain are peptidases.
Links
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Statistics
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PSSM-Id: 460797
Aligned: 160 rows
Threshold Bit Score: 83.8314
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_018436412  186 TREFSLAQTWVV-NGd-W--Dt----gLNSLESGWQILHALYGDKNPRLFAYWTSdTYQetG----CYNLDCPGFVQVSR 253
EDR05125      237 VGDFSLSQQWYVgGSgaN---------LQTVEGGWVVYPGKFKTKNAVLFIFYTAdNYKtkK----CWNLDCAAFVQTNK 303
XP_001882591  224 VGDFSLSQQWYVgGSgaS---------LQTAEGGWVVYPQHF-STQAVLFIFWTPdDYt-tG----CYNLECKAFVQISN 288
EDR02747      226 VGDFSISQQWYVgGSgaS---------TQTVEGGWIVYPQKF-SAQAVLFIFYTPdDYs-tG----CYNLECKGFVQINN 290
jgi:Msil_1094 230 SQIFSLSQHWYV-GGngAg--------LQTAETGWQVYPKFYNTPKPVFFIYWTAdGYTntG----CYNLTCAAFVQTNN 296
CCA89892      156 DQIFSLCQHWYS-AGagAa--------HQTVEVGWQVYPAKYGHSQPVLFIYWTAdNYGpsG----AYNLDKAGFVQTNS 222
XP_007811872  153 DGDFSLLQVAV--VHerAdqPngaakqDQTVEAGWTNYPVL-HKGGPILFAFYTTnGYRgqAdyvgGYNFKVKGWFQQDR 229
EFJ13886      141 TSEFSLAQLWIIsKKlgP---------LNTIEAGWQIYPKFYGGTGPRLFVYWTAdGYDktG----CYNLRCQGFVQTSN 207
EFJ20181       38 SNNFSLSQFWVVh----La-Gq----tKTTLEAGWQVFPSMYGNNEPHLFVYWTAdDYQhtG----CYNLECPGFVQVSN 104
EFJ17631       31 PREFSLSQFWLI-SSydRh-Gv----pRSTMEAGWQIYPSLYGGDDPRLFVYWTAdGYNstG----CYNLGCDGFVQVSS 100

XP_018436412  254 HISLGAALNt-FSTYNg--eQYDFLLTIEKDQETGLWWLKFE-----TYlIGYWPSFIVPk-------lAVS-ARKIAWG 317
EDR05125      304 NWFLGRGFTh-YSAFGggqwGFEMQWKLV----GGNWWLYLKgp-gaYEaVGYYPTKIFGsg------qLSKsAEVVEYG 371
XP_001882591  289 KWNLGGTFDq-YSVTGdgqrGFDLQYKLF----QGNWWLFLRgssanYDaVGYYPGSIYNkg------qLTKnAELVEYG 357
EDR02747      291 NWQLGGTFGq-YSVTGgvqkGVDLQWYFY----QGNWWLYLRga-gaYDaVGYYPGSIYNgg------qLTKsAQLIEYG 358
jgi:Msil_1094 297 SWAVGGALKp-WSTSPk--kQVVLELSYF--LFQGRWWLYVNgt-aaANaIGYYPATLYKgg------aMSVgAQEIDYG 364
CCA89892      223 DWTIGGTLSp-VGSGGg--qQYEIEIAFY--LNGGNWWLYLGgl-saQHaVGYYPASLFNgg------aMASnATKALFG 290
XP_007811872  230 EIYPGMPISa-FSVEGgkqeEIEIRYKLF----NNCWWLYTMg----RY-IGCYPTSLFAregvnpkntLATsATNILLY 299
EFJ13886      208 KYVLGGSFSs-VSTPDs--tQYEKTLRVFQDDSSKNWWLQID-----GEsIGYWPASLFQs-------lQNG-AETLEAG 271
EFJ20181      105 KIVPGATLRp-ASQHGg--pQTVLSFLVYQDPETKNWWLRVE-----DEyVGYWPGSLVPn-------lANG-ATHVDFG 168
EFJ17631      101 SIVLGGAISsrTSTAGs--tQSHKVVCVLQDPRSGNWWLRVS-----GSyVGYWKASALPd-------fANG-ASAVSCG 165

XP_018436412  318 GEIVYYtrgqGTHTLTQMGSGHFAEKGFRKAAYFNSLEy-----------Idt----snYPitPSPQHLEATVT-RPECY 381
EDR05125      372 GEVTRDs---ADHRWPQMGSSIFPSYGFGQSAFQRTIYytardepg---------------gvgvwtnLQKLVIgSNKCW 433
XP_001882591  358 GEVTRFt---TADVWPQMGSGMFPSKGYSQAAFQNTIYynprdesd---------------gvgvwsfLTKVVVgSHSCW 419
EDR02747      359 GEVLRFt---TAVAWPQMGSGMFPDKGFEQAAYQNAIFysppdvngsaspTvw-------------sdLTKAVIgSRSCW 422
jgi:Msil_1094 365 GEVVg-----TK-SWPPMGSGKFASLGFGKAAYQSDIYyfpp-----agaNvpan-ltvSQ--DWPWAY---TG-SFSYL 426
CCA89892      291 GETVCGa---AG-PWPEMGSGAFSGAIYPHAAWQRAVFvmpk-----sggAqwas-ltgQS--PSPGCYDQFIG-SYTa- 356
XP_007811872  300 GEVYNTg---ERLTTTDMGTGRHASEGWKYAASMRVMKw-----------Vdtn--gqeHD--WS-GFVH--AD-DPARY 357
EFJ13886      272 GEVCYDkesgVRHTKTGMGSGEFPSQGYLKAAYQRRIQy-----------Lds----ngVM--QPAIGMKSGAE-VPKCY 333
EFJ20181      169 GEVFYYkg--seHTTTQMGSGEFPEAGFKNAAYHRDMYhv---------lLgndhalhyTL-----LALNDRFSrVPSCY 232
EFJ17631      166 GEVLe----aNRHTRTQMGSGAFPNAHYKYAAYHRDIQi-----------Vna----nfRL--QQAQNMARVAVkKPGCY 224

XP_018436412  382 N-LMVGSSQR----WGTYFFYGGP 400
EDR05125      434 DiNITQAAQGg--sWGTYFFFGGP 455
XP_001882591  420 DiNITESAQGg--gWGTFFFFGGP 441
EDR02747      423 DiNITESAQGg--dWGTFFFFGGP 444
jgi:Msil_1094 427 Ns-----------pNFSTLFFGGP 439
CCA89892      357 -------------pWNITLFYGGP 367
XP_007811872  358 SiMPRFQSGWq--gWHSHMFLGGP 379
EFJ13886      334 TaTSVAADKGd--dWGAYFFFGGP 355
EFJ20181      233 R-VGPALNTNgd-tWKNYFFFGGP 254
EFJ17631      225 D-IGTIQDAGrntsWGTYFFYGGP 247
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