Conserved Protein Domain Family
PspC_subgroup_2

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NF033839: PspC_subgroup_2 
pneumococcal surface protein PspC, LPXTG-anchored form
The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.
Statistics
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PSSM-Id: 468202
Aligned: 6 rows
Threshold Bit Score: -1
Created: 24-Apr-2023
Updated: 3-May-2023
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAF73803   1 MFKSNHERRMRYSIRKFSVGVASVAVASLFMGSVVHATEREGSTQAATSSKMANESQIERRKAaeqaivslsgymtslln 80 
AAF73791   1 MFKSNYERKMCYSIRKFSIGVASVAVASLVMGSVVHATENEGTTQAPTSSNRGNESQAEQRRE----------------- 63 
AAF73826   1 MFKSNHERRMRYSIRKFSVGVASVAVASLFMGSVVHATEKEGSTQAATSFNRGNGSQAEQREE----------------- 63 
AAF73782   1 MFKSNHERRMRYSIRKFSVGVASVAVASLFMGSVVHATEKEGSTQAATSFNRGNGSQAEQRGE----------------- 63 
AAL90446   1 MFASKNERKVHYSIRKFSIGVASVAVASLFMGSVVHATEKEVTTQVATSSNKANKSQTEHMKAakqvdeyiekmlseiql 80 
AAF73793   1 MFASKSERKVHYSIRKFSIGVASVAVASLVMGSVVHATENEGSTQAATFSNMANKSQTEQGE------------------ 62 
AAF73803  81 dgldtsdsrfeellkrakgiveeyrkkidgasdrekieklqqegqtkldelvdkfkkglssseqnghatpkdpsrndgvq 160
AAF73791     --------------------------------------------------------------------------------    
AAF73826     --------------------------------------------------------------------------------    
AAF73782     --------------------------------------------------------------------------------    
AAL90446  81 drrkhtqnvglltklgaikteylrglsvskekstael------------------------------------------- 117
AAF73793     --------------------------------------------------------------------------------    
AAF73803 161 gddssvgqgeqpgasnqknpesvpptasgetdsptkpktsndsvnslerelkevketakttlntymltrlkqenpgvfwf 240
AAF73791     --------------------------------------------------------------------------------    
AAF73826     --------------------------------------------------------------------------------    
AAF73782     --------------------------------------------------------------------------------    
AAL90446 118 ---------------------------------------------------------------------------pseik 122
AAF73793     --------------------------------------------------------------------------------    
AAF73803 241 adllreskesvekykrmcdeasskenvenlvkeakqeiealvvkhkgrgIDLERTKAKTVIAKYLTGLLDDIKKNLKKEQ 320
AAF73791  64 -------------------------------------------------LDLERDKVKKEVREYKEKKVKELYSKSTKSR 94 
AAF73826  64 -------------------------------------------------LDSERDKARKEVEEYVKKIVGESYAKSTKKR 94 
AAF73782  64 -------------------------------------------------LDLERDKAMKAVSEYVGKMVRDAYVKSDRKR 94 
AAL90446 123 ekltaafeqfkkdtlksgkkvaeaqkkakdqkeakqeiealivkhkgreIDLDRKKAKAAVTEHLKKLLNDIEKNLKKEQ 202
AAF73793  63 -------------------------------------------------INIERDKAKTAVSEYKEKKVSEIYTKLERDR 93 
AAF73803 321 HINTVELIKKLGDIKRTYLYKLDESTQK----PTTGTGPESHQTRSFSNLKWLSSSSVRILINQKSA------------- 383
AAF73791  95 HKKTVDIVNKLQNINNEYLNKIIQSTSTyeelQKLMMESQSEVDKAVSEFEKDLSSSSSSGSSTEPEasdtakpnkptel 174
AAF73826  95 HTNTVALVNELNNIKNEYLNKIVESTSEsq-lQILMMESRSKVDEAVSKFEKDSSSSSSSDSSTKPEtp----------- 162
AAF73782  95 HKNTVALVNQLGNIKNRYLNEIVHSTSKsq-lQELMMKSQSEVDEAVSKFEKDSFSSSSSGSSTKPEtp----------- 162
AAL90446 203 HTHTVELIKNLKDIEKTYLHKLDESTQKaq-lQKLIAESQSKLDEAFSKFKNGLSSSSNSGSSTKPEtp----------- 270
AAF73793  94 HKDTVDLVNKLQEIKNEYLNKIVESTSKie-iQGLITTSRSKLDEAVSKYKKAPSSSSSSGSSTKPEtp----------- 161
AAF73803     --------------------------------------------------------------------------------    
AAF73791 175 ekkvaeaqqkveeaekkakdqkeedhrnyptityktleleiaefdvkvkeaelellkvkakesrdekkikqaeaeveskq 254
AAF73826     --------------------------------------------------------------------------------    
AAF73782     --------------------------------------------------------------------------------    
AAL90446     --------------------------------------------------------------------------------    
AAF73793     --------------------------------------------------------------------------------    
AAF73803     --------------------------------------------------------------------------------    
AAF73791 255 aeatrlkkiktdrkkaeeeaklkeaveknaatseqgkpkrrvkrgalgeqatpdkkdyfekdfrpafnknqqmvaiqesl 334
AAF73826     --------------------------------------------------------------------------------    
AAF73782     --------------------------------------------------------------------------------    
AAL90446     --------------------------------------------------------------------------------    
AAF73793     --------------------------------------------------------------------------------    
AAF73803     --------------------------------------------------------------------------------    
AAF73791 335 nklddetktvpdgakltgeagnaynevrdyaikvvsenkkllsqtavtmdelamqltklndamsklkeakaklvpevkpq 414
AAF73826 163 -------------------------------------------------------------------------------q 163
AAF73782 163 -------------------------------------------------------------------------------q 163
AAL90446 271 -------------------------------------------------------------------------------q 271
AAF73793 162 -------------------------------------------------------------------------------q 162
AAF73803 384 PEKPEHQ---NPTTPAPDTKPSPQPEGKKPSVPDINQEKEKAKLAVATYMSKISDDIQKHHLQKEKHRQIVALIKELDEL 460
AAF73791 415 PENPEHQ---RPTTPAPDTKPIPQPEGKKPSVPDINQEKEKAKLAVATYMSKILDDIQKHHLQKEKHRQIVALIKELDEF 491
AAF73826 164 PENPEHQ---KPTTPAPDTKPSPQPEGKKPSVPDIYPGIEKAKLAVATYMSKILDDIQ-------KHRQIVALIKELDEL 233
AAF73782 164 PENPEHQ---KPTTPSPDTKPSPQPEGKKPSVPDINQEKEKAKLAVVTYMSKILDDIQNIICRKKNIVRLLALIKELDEL 240
AAL90446 272 PE-----------TPKPEVKPELE-----TPKPEL----ETPKPEVK--------------------------------- 298
AAF73793 163 PETSKPEvkpEPETPKPEVKPEPE-----TPKPEVKPEPETPKPEVK--------------------------------- 204
AAF73803 461 KKQALSEIDNVNTKVEIENTVHKIFADMDAVVTKFKKGLTQDTPKEPGNKKPSAPKPGMQPSPQ---------------- 524
AAF73791 492 KKQALSEIDNVNTKVEIENTVHKIFADMDAVVTKFKKGLTQNTPKEPDNKKPSAPKPGMQPSPQpegkkps--------- 562
AAF73826 234 KKQALSEIDNVNTKVEIENTVHKIFADMDAVVTKFKKGLTQDTPKEPGNKKPSAPKTGMQPSPQpevkpqpknqnqrlnr 313
AAF73782 241 KKQALSEIDNVNTKVEIENTVHKIFADMDAVVTKFKKGLTQDTPKEPGNKKPSAPKTGMQPSPQpevkpqpknqnqrlnr 320
AAL90446 299 -----PELETPKPEVKPE----------------------PETPKPEVKPELETPKPEVKPEPEtpkpevk--------- 342
AAF73793 205 -----PELETPKPEVKPE----------------------PETPKPEVKPEPETPKPEVKPEPEtpkpevk--------- 248
AAF73803 525 ----------------------------PEVKPQLEKPKPEVKPQPEKPKPEVKPQLEKPkp---evKPQPEKPKPEVK- 572
AAF73791 563 ---------------------vpaqpgtEDKKPSAPKPGMQPSPQPEGKKPSVPAQPGTE-------DKKPSAPKPGMQp 614
AAF73826 314 nqknqnqrlnrnlekpkpevkpqpekpkPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPkp---evKPQPEKPKPEVN- 389
AAF73782 321 nqknqnqrlnrnlekpkpevkpqpekpkPEVKPQPEKPKPEVKPQPEKPKPEVKPQLEKPkp---evKPQPEKPKPEVN- 396
AAL90446 343 ---------------------pepetpkPEVKPELETPKPEVKPEPETPKPEVKPELETPkpeletpKPELETPKPEVK- 400
AAF73793 249 ---------------------peletpkPEVKPELETPKPEVKPEPETPKPEVKPELETPkp---evKPEPETPKPEVK- 303
AAF73803 573 -PQPEKPKPEVKPQPEKPkpevKPQPEKPKPEVKPQpekpkpevkPQPEKPKPEVkPQPEKPKPEVKPQPEKPKPEVKPQ 651
AAF73791 615 sPQPEGKKPSVPAQPGTE----DKKPSAPKPDMQPS---------PQPEGKKPSV-PARQPGTEDKKPSAPKPDMQPSPQ 680
AAF73826 390 -PQPEKPKPEVKPQPEKPkpevKPQPEKPKPEVKPQpekpkpevkPQPEKPKPEVkPQPEKPKPEVKPQPEKPKPEVKPQ 468
AAF73782 397 -PQPEKPKPEVKPQPEKPkpevKPQPEKPKPEVKPQpekpkpevkPQPEKPKPEVkPQPEKPKPEVKPQPEKPKPEVKPQ 475
AAL90446 401 -PELETPKPEVKPEPETPkpevKPELETPKPEVKPEpetpkpevkPELETPKPEL----ETPKPEVKPELETPKPEVKPE 475
AAF73793 304 -PELETPKPEVKPEPETPkpevKPELETPKPEVKPEpetpkpevkPEPETPKPEVkPEPETPKPEVKPEPETPKPEVKPE 382
AAF73803 652 PEKPKPEVKPQLEKPKPEvkpqLEKPKPEVKPQlekpk----pdnskPQADDKKPSTTnNLSKDKQPSNQASTNEKatnk 727
AAF73791 681 PEGKKPSVPAQPGTEDKK----PSAPKPDMQPS--------------PQPEGKKPSVP-EINQEKEKAKLAVATEK---- 737
AAF73826 469 PEKPKPEVKPQPEKPKPEvkpqPEKPKPEVKPQpekpk----pdnskPQADDKKPSTTnNLSKDKQPSNQASTNEKatnk 544
AAF73782 476 PEKPKPEVKPQPEKPKPEvkpqPEKPKPEVKPQpekpk----pdnskPQADDKKPSTTnNLSKDKQPSNQASTNEKatnk 551
AAL90446 476 PETPKPEVKPEPETPKPE----LETPKPEVKPEleipkpevkpdnskPQADDKKPSTPnNLSKDKQSSNQASTNENkkqg 551
AAF73793 383 PETPKPEVKPEPETPKPEvkpePETPKPEVKPEpetpkpevkpdnskPQADDKKPSTPnNLSKDKQSSNQASTNENkkqg 462
AAF73803 728 -----pkkSLPSTGSISNLALEIAGLLTLAGATILAKKRMK 763
AAF73791 738 --------KLPSTGVASNLVLEIIGLLGLIGTSFIAMKRRK 770
AAF73826 545 -----pkkSLPSTGSISNLALEIAGLLTLAGATILAKKRMK 580
AAF73782 552 -----pkkSLPSTGSISNLALEIAGLLTLAGATILAKKRMK 587
AAL90446 552 patnkpkkSLPSTGSISNLALEIAGLLTLAGATILAKKRMK 592
AAF73793 463 patnkpkkSLPSTGSISNLALEIAGLLTLAGATILAKKRMK 503
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