Conserved Protein Domain Family
DUF3522

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pfam12036: DUF3522 
Protein of unknown function (DUF3522)
This family of proteins is functionally uncharacterized. This protein is found in eukaryotes. Proteins in this family are typically between 220 to 787 amino acids in length. This family belongs to the CREST superfamily, which are distant members of the GPCR superfamily.
Statistics
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PSSM-Id: 463441
Aligned: 50 rows
Threshold Bit Score: 104.67
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006827525                  635 MWQSIALIFSNIAAVFPALWALRQKAFAEWVLFTSSGLSSGLYHACD-VG---SWCALSFHVLQFM----------DFWL 700
Q4DL71                         12 WVTFITCCLSHLALLPAIRYLQKRGMHYEVCVSVFSTLVSFLYHSSEs--------LRTP-LF-LStirw---hrlDNIG 78  Trypanosoma cruzi...
ESS32612                       44 HAQLVTTGATNVVLLFGILRSWQVGLPVDAFVGFAAMVTSVAYHTLQtLEgnnPHVFEKARFLGGTegdw---hraDNIF 120
Q55D80                         13 VLQAFIAFSTNLSVIPVVYHCLKRGSAYEGIIGISCALASMMYHVGEv--------FENTWWFKLSgmtsgqwhrlDNVF 84  Dictyostelium discoideum AX4...
XP_004367252                    9 ALQALIAFGTNLSCLPLGIMCVKRGTAYEAIVGTACALCSMLYHVGEv--------YEKTWWFKLSgmtsgqwhrlDNIF 80 
EFA83638                        9 MMTAVIAFTTNLSCIPLGVMCVKRGHAYEAVVGVACAISSMMYHIGEi--------YEKTWWFELSglnadkwhrlDNIF 80 
A0CLA3                         18 FLMVIITAVSNGVMIPQIIYTYKIKNVHTLFLSGLLFVSSFMYHLSEs--------IGVEPII-LKevdw---hqlDNIA 85  Paramecium tetraurelia...
WGS:AAGF:cds.TTHERM_00497870A  22 FMMVLITAITNFACMPALCLLYKKNLVFETYVGVFTFVTSFMYHFVEs--------IGAEKLF-MKelew---hqlDNIG 89 
A0DY57                         20 FMMVLITGITNFVVIPAIIIIRKQRMDFQFYISIFTLITSFMYHTLEs--------VDCK-YFIIEeggw---hrlDNVG 87  Paramecium tetraurelia...
EEY61896                        8 TMMLAVTGITNFCMFPAIYSLYRRQFVFEAFIGLFTMATSFMYHVCDs--------IDGP-LW-LTegqw---hrlDNIG 74 
XP_006827525                  701 SFVAVVSTFIYMAKI--EEVSKRAIHTSVAILTALIAAEGPTRSENIIIV-VSLGILGLVVGWmielyssrahtlscpqf 777
Q4DL71                         79 AISSITIVCLHVCSFe-SEKLVNYLKYFFLFVTIVLQEADPWNILYTAIP-ILCALAMVLVAMllsp------------- 143 Trypanosoma cruzi...
ESS32612                      121 AITCIISFFAMPLQLv-SPVWVLMTRMVPLCVVAISQCLQPWNFAYTIFPiIFFGVGFLVLLAvsr-------------- 185
Q55D80                         85 TILTFQALCFFLMDIq-SQQSTELLRWTFLVITLYCQERAPWQIEFTIIP-IVSALILLIIRHslrr------------- 149 Dictyostelium discoideum AX4...
XP_004367252                   81 TILAFQALMFYLTDVs-NPQIMDLLRWTFLVFTLYCQERAPWDITYTILP-IGASFLLLIVSHlyrr------------- 145
EFA83638                       81 TILAFQAMMFYLMEYn-HPQIVDLLRWIFLVFTLYCQMINPWNLAFTILP-IVSSLFLLICTHiykk------------- 145
A0CLA3                         86 SICGLMELFNYLMQN--NRSTRKSIQWINFIFVVIIQESHAWNVWATVIP-ILISLIIFIIKQtfyp------------- 149 Paramecium tetraurelia...
WGS:AAGF:cds.TTHERM_00497870A  90 AIMCFITVFIHMANFq-NYNLQMQLNYSAMFIVIILQVADPWNLTFTVAP-IVIYALI-IIALaiyl------------- 153
A0DY57                         88 SIVCFQMLFTQLSDLq-NLHLETMLNYFGLFVTFIAQAKSPWDLNYTVGP-ILMQLFICIFLIikr-------------- 151 Paramecium tetraurelia...
EEY61896                       75 SIMSFVMWSIHLMDLgvHPVLERYVQYFFLGMVLVFQEKNPWDERNSVIP-VASSFVLLLMTYamr-------------- 139
XP_006827525                  778 nlnvmerwqelktgvvklidwlrKRFQWRFIFLGFIALLAAG--TCWN-LESVESYWIWHSLWHV 839
Q4DL71                        144 --------------------irrRRIAGKNLYVGMASSLLGVicFLRGlDEDRDTYRAWHGLFHV 188 Trypanosoma c...
ESS32612                      186 ---------------------vrPRLQRRSCLYSGVTFILAMvfFFFGmDDANDYLRIKHGFWHI 229
Q55D80                        150 --------------------kipDWIKSKFFLYGFGFFGVAAffFARGlDDNNDYLRINHGIWHF 194 Dictyostelium...
XP_004367252                  146 --------------------rvpEWIKNRYFLYGLGCLVVAGffFARGlDDDTDYLRWNHGVWHF 190
EFA83638                      146 --------------------kipEWIKNRYFLYGIGSLGIAAffFARGlDDENDYLRINHGIWHL 190
A0CLA3                        150 --------------------kkgQIVNKDYLHKGLFYLFIGFiaFYFGlDEYKDYLRLWHGLWHL 194 Paramecium te...
WGS:AAGF:cds.TTHERM_00497870A 154 --------------------ktqPFTNRQMTIKGFSLIFLGAifFSLSqDEHTDYLRIYHGLWHs 198
A0DY57                        152 --------------------rrlPKLNKQKMKKGLLILLAAIvfFSLSqDEYQDYLRFYHGMWHT 196 Paramecium te...
EEY61896                      140 --------------------rrvPTYDYQQFRRGLLLLVCGIlcFVRGlDDDTDPFRFFHGCWHg 184
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