2DZE


Conserved Protein Domain Family
ASF1_hist_chap

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pfam04729: ASF1_hist_chap 
ASF1 like histone chaperone
This family includes the yeast and human ASF1 protein. These proteins have histone chaperone activity. ASF1 participates in both the replication-dependent and replication-independent pathways. The structure three-dimensional has been determined as a a compact immunoglobulin-like beta sandwich fold topped by three helical linkers.
Statistics
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PSSM-Id: 461412
Aligned: 68 rows
Threshold Bit Score: 147.666
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2DZE_B                     6 ILSVNVL-NNPAKFSDPYKFEITFECLEP-----LKSDLEWKLTYVGSATSQSYDQILDTLLVGPIPI-GINKFVFEADP 78  fis...
WGS:AAFB:cds.EHI_127360A   4 LTKINSLfPNPSTMNDGYSFEIYINVSEQ-----LQEDIGIKVIYVGSSFSNEYDQILEDIAVGPLSV-GLNKFTITTGP 77 
Q5CQH0                    15 VTSVKVF-KNPTEITDPFEFEISFECLQN-----LEEDLEWKIVYISCAESKDMDQELDCIALGPITR-GALKFIFKAPS 87  Cry...
EGR28891                   6 IQNIQFQ-NNPSPFQSPLRLDITFECLKQ-----IPEEIEWQLIYIGSAKDELYDQVLDKFSMGDLDQ-GVMQFTIESNP 78 
A0CU44                     6 ITNIVVE-DKPQPFTSPITMDIYFDVIAD-----IEDEIEWTLLYIGSPKDEAHDQILDQFSMGPLTK-GTKQFTLESNP 78  Par...
A0CKQ8                     6 VTNIIFE-NELALFQTPISMQITFEVLND-----LTDEIEWNLIYIGSPLSEKFDQVLDNFSMGPLQR-GVMQFTITSQP 78  Par...
A0DPW8                     6 ITNIVFD-QDTALFNSPIQMQITFDVMRQ-----LDEEIEWKLIYIGSPNSDKYDQVLEQFSMPPLQQ-GTMQFTLMSSG 78  Par...
Q4CQS3                     7 LRGISVVgSNPAPFSDPIVLKVLLEVFEKppvqaIDVKFTWKLIWDFPV-----DQELDEFEVGPLTTlGVHELTLQSDP 81  Try...
CAM66879                   7 LRKVQVLgPNPSKFDTPIRLHLVLDVFEKppkdaIDVTFTWSPVWDFPV-----DQELDEMEVGPFTTlGRHEFTIESDP 81 
Q4GZF6                     9 LLEIELIgDNPSSYTQPMHWRMRLEALEA-----LDDTISIAFVWVGSAASPNHDQVLDSFDVGPLAQ-GVTEFTMECDP 82  Try...
2DZE_B                    79 PNIDLLPQlSDVLGVTVILLSCAYEDNEFVRVGYYVNNEMEGlnLqemdDAEikkvkvdISKVWRSILa-EK-------P 150 fis...
WGS:AAFB:cds.EHI_127360A  78 IDMSKLPD-DEILGNTLILISASYKDKEFCRIGYYVNNEFEG--I----DPT-------IDVVKREMLvpEKitrtlseP 143
Q5CQH0                    88 PDFTKIPP-EDIHGMAVVLILGSYRNEEFIRIGYYVHNVYTDplLe--dNPPdi---piLDKLQRIILs-ES-------P 153 Cry...
EGR28891                  79 PDHTKIPSkEDLLGVTAIILTVSYRNQEFFRVGYYVYNQYTDpeLi--eNDPte---vlIDKVERNILa-NQ-------P 145
A0CU44                    79 PDWKKIPQ-DEVLGITAFILTCSYRQREFFRVGYYVYNTYTSpeNi--eNDPqe---viIEDIARQIFn-NK-------P 144 Par...
A0CKQ8                    79 PNYQLIPSkEDLFSVSALILTAKYRQKEFFRVGYYVYNNYTEaeLi--eNEPqv---vlIDRVYRQIMg-SN-------P 145 Par...
A0DPW8                    79 PNFELIPSkDDLFGASAIILSVKYRKQEFFRVGYYVYNTYLEpeLi--eNDPpq---vlIDRVYRQINt-SA-------P 145 Par...
Q4CQS3                    82 PDFSKIP---DPTGPTALIISFTYEGREFLHIGYNAVVTCEGempd---------vfesAEQLRRHLTq-CF-------P 141 Try...
CAM66879                  82 PNVADIP---DPTGPTALIVSLKYQGDEFLHIGYNITVTCEGdlpd---------vftsADMLTRHIGk-CY-------P 141
Q4GZF6                    83 PQVELVPT-QEVLGVTILVISFQYREQEFLRVGYYTQVAYFDgrMn--nCPPpv---pqVELMGRFIAm-PR-------P 148 Try...
2DZE_B                   151 RVTRFNIQWD 160 fission yeast
WGS:AAFB:cds.EHI_127360A 144 RVTLFPCYWD 153
Q5CQH0                   154 RLTRFNIGWD 163 Cryptosporidium parvum
EGR28891                 146 RITHFNIKWg 155
A0CU44                   145 RITRFEIDWN 154 Paramecium tetraurelia
A0CKQ8                   146 RITKFPIDWE 155 Paramecium tetraurelia
A0DPW8                   146 RVTRINIDWE 155 Paramecium tetraurelia
Q4CQS3                   142 KQ--LSIVWD 149 Trypanosoma cruzi
CAM66879                 142 KL--RDISWD 149
Q4GZF6                   149 TVTVTPIAWN 158 Trypanosoma brucei
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