2I5K


Conserved Protein Domain Family
UDPGP

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pfam01704: UDPGP 
UTP--glucose-1-phosphate uridylyltransferase
This family consists of UTP--glucose-1-phosphate uridylyltransferases, EC:2.7.7.9. Also known as UDP-glucose pyrophosphorylase (UDPGP) and Glucose-1-phosphate uridylyltransferase. UTP--glucose-1-phosphate uridylyltransferase catalyzes the interconversion of MgUTP + glucose-1-phosphate and UDP-glucose + MgPPi. UDP-glucose is an important intermediate in mammalian carbohydrate interconversion involved in various metabolic roles depending on tissue type. In Dictyostelium (slime mold) mutants in this enzyme abort the development cycle. Also within the family is UDP-N-acetylglucosamine or AGX1 and two hypothetical proteins from Borrelia burgdorferi the lyme disease spirochaete Swiss:O51893 and Swiss:O51036.
Statistics
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PSSM-Id: 460300
Aligned: 76 rows
Threshold Bit Score: 373.002
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2I5K_A          41 LDSFFTLFRRYLVE-KSsrTTLEwDKIKSPNPDE----VVK-YEIIs--QQPENVSNL----SKLAVLKLNGGLGTSMGC 108 baker's yeast
XP_009435025    45 LNFFFQKAIEGFNQ-SShqKNVD-ARMEPVPREVlgsaTRD-QDQL---QAWESEGLFqisqNKVAVLLLAGGQGTRLGV 118
WP_014259044    39 inifkyyYSLLLS---GsqGKMAeADITPISPDD----LKD-YLELd-aYEAAGRKAL----PKVAIIKLNGGLGTSMGL 105 Desulfocurvib...
WP_015773692    36 intFKCYFNQFLY---GaqVKLSdRDVMAVHDDE----LAD-YDAMe-qFKDKGEKAL----GKTAVIKLNGGLGTSMGL 102 Desulfomicrob...
kribb:BBB_0904  35 isQFRHAYHVWASE--KesAWIReDAVEPLHGVRs---FHDvYKTI---DHDKAVHAF----AKTAFLKLNGGLGTSMGL 102
WP_015752000    24 iDLFREYYQQLAS---GhtGKLSeAAIRPLDKANd---LLH-QDDLtaeAGTNGRHTL----DQTVMIKLNGGLGTSMGM 92  Desulfohalobi...
WP_015424819    19 irtFEAYYQKLVK---GekGLIGeDAIRPPSEKN----LID-YQQI---KHLSRTSIL----KNTVVIKLNGGLGTSMGL 83  Candidatus Cl...
EJT43938        46 LSLFLHIFQRYILEnTSitHDLDpNEIRLLSAEE----IVE-FEDIq-nEELFDPALI----SKVAILKLDGKNNSIISK 115
NP_997786       45 INNFFKSAMKTSGQ--SsqEKVD-TRMEPVPRDVlgsvTRD-RECL---KEWEKEGLRciaeNKVAVLLLAGGQGTRLGV 117
XP_014343146   439 iNAFFSKAMKASNC-CSgqEKVD-RRMEPVPRDVlgsvSRD-RERL---REWEQEGLFqisqNKVAVLLLAGGQGTRLGV 512 coelacanth
2I5K_A         109 VGPKSVIEVR----EGNTFLDLSVRQIE------YLNRQYDSDVPLLLMNSFNTDKDTEHLIK--KYSA-NRIRI-RSFN 174 baker's yeast
XP_009435025   119 AYPKGMYDVGl--pSRKTLFQIQAERILklqqvaEKYYGNKCIIPWYIMTSGRTMESTKEFFTkhKYFGlKKENV-IFFQ 195
WP_014259044   106 ETAKSLLAIK----AETCFLDVIIEQVE------RLRERYDIPVPLTLMNSFHTHSDSMLAIE--GFDN-GRTRVpLAFI 172 Desulfocurvib...
WP_015773692   103 ESAKSLIPVK----EGLSFLDLILLQAS------TVRTHYGVDFPQVFMNSFKTHMDTM--LKvgDFHN-GTTGIdLAFL 169 Desulfomicrob...
kribb:BBB_0904 103 QCAKSLLPVRrhkaRQMRFLDIILGQVL------TARTRLNVPLPVTFMNSFRTSDDTMKALR--HQRKfKQTDIpLEII 174
WP_015752000    93 PYAKSLLEVK----QGNNFLDVIVMQCN------GCDGQLQYSIPLALMDSFATHQETNDYLQ--QQGIrLGQDV-FTFL 159 Desulfohalobi...
WP_015424819    84 SKAKSLLPVK----NNLNFLDIISRQVL------TLRSLSGYDVLLLFMNSFNTEADTLKYLE--KYPDlGKQDLpLSFL 151 Candidatus Cl...
EJT43938       116 ASP--LLEVK----NGKCSLDIIVQQTQ------NLNTKWNSDVPLIFMTSLETESHTTNFLE--KHYSsDEVTW-KTIV 180
NP_997786      118 SFPKGMYDVGl--pSHKTLFQIQAERIRkleqlaEKQHSRKCCIPWYIMTSGRTMDMTKDFFIqhKYFGlKEENV-VFFQ 194
XP_014343146   513 SYPKGMYDVGl--lSHKTLFHIQAQRILklevlaEEHYGTKCTIPWYIMTSGRTMESTEEFFTkhNYFGlKRDNV-IFFQ 589 coelacanth
2I5K_A         175 QSRFPRVYKDSLLPVPTEYds-plDAWYPPGHGDLFESLHVSGELDALIAQGREILFVSNGDN-LGATVDLKILNHMIET 252 baker's yeast
XP_009435025   196 QGMLPAMSFDGKIILEEKNk----VSMAPDGNGGLYRALAAQNIVEDMEQRGIWSIHVYCVDNiLVKVADPRFIGFCIQK 271
WP_014259044   173 QHMYPKIMRDTFLPARWPKnp--eLEWNPPGHGDLYTAMVTSKTLKRLEESGFEYAFISNSDN-LGAVMDLKILGYMASE 249 Desulfocurvib...
WP_015773692   170 QHRYPKIMAKDHSPASWPRnp--eLEWNPPGHGDIYTAMITSGILDALLDKGYLYAFISNSDN-LGAIMNRRLLGYMVHH 246 Desulfomicrob...
kribb:BBB_0904 175 QHQEPKIDAATGAPASWPTnp--dLEWCPPGHGDLFSTLWESGLLDTLLEHGFEYLFISNSDN-LGARPSRTLAQYFEDT 251
WP_015752000   160 QHKFPKIRQDTLEPATYPEdp--eLEWNPPGHGDIYAALETSGLLNQLLSDGYRYAFVSNSDN-LGAVVDSRLLGAFADS 236 Desulfohalobi...
WP_015424819   152 QNKFPRIRQDTLMPYENKEt---kLMWNPPGHGDIYTAL--GDLLDKMIAKDYRYAFVSNADN-LGAVVDTSIPAYMENN 225 Candidatus Cl...
EJT43938       181 QSCFPVIDKNRLLPIDLQAnsnkeDLWYPCGTGNLTDTLYFSGELDNLIARGKEFLFVSNVNN-LGATVDLNILSYMVSE 259
NP_997786      195 QGMLPAMDFNGKIILEGKCk----LAMAPDGNGGLYRALGTQNIVKDMETRGISYIHVYCVDNiLVKVADPAFIGFCTLK 270
XP_014343146   590 QGMLPALTFEGKIILEGKSk----VSMAPDGNGGLYRALGAQKIVDDMERRGVEHIHVYCVDNiLVKVADPVFIGFCVKK 665 coelacanth
2I5K_A         253 GAEYIMELTDKTRADVKGGTLI--SYDGQVRLLEVAQVpKEHIDEFKNIRKFTNFNTNNL---WINLKAVK-RLI-ES-S 324 baker's yeast
XP_009435025   272 GADCGAKVVEKTNPTEPVGVVC--RVDGVYQVVEYSEI-SLATAQKRSSDGRLLFNAGNIanhFFTVPFLR-DVVnVYeP 347
WP_014259044   250 DLPFLMEVAQRTPADKKGGHLCkvKESGRLALREVAQCpDEELAEFQNIEKYAFFNTNSI---WINLKVLE-KVFaYH-G 324 Desulfocurvib...
WP_015773692   247 NLPFLMEVARRTEQDKKGGHLCrlKKNKQLALREVAQCpDNEMESFCDIEKYKFFNTNSI---WIDLRILQ-SVFiSH-R 321 Desulfomicrob...
kribb:BBB_0904 252 GAPFMVEVANRTYADRKGGHIVrdTATGRLILREMSQVhPDDKDAAQDIAKHPYFNTNNI---WVRIDVLR-DMLaEHdG 327
WP_015752000   237 GTPFMIEVCRRTGADTKGGHLAr-HKDGRLILREIAQCpDEELDAFQDVERFKYFNTNNI---WIDLQQLR-DFIdAH-G 310 Desulfohalobi...
WP_015424819   226 NIPFVMEVCLRSQMDKKGGHLCe-DKSGQLLLREIAQCpEEDLPRFQDIDYYKYFNTNNI---WIDLRALEwQMIaNE-G 300 Candidatus Cl...
EJT43938       260 KIDYLVEVVERTANDSNTGVLA--TYKNKLRLVDYDCL------SNESARNCRIVNTNNI---WIDLRSLK-RLV-ES-D 325
NP_997786      271 GADCGAKVVEKTNPTEAVGVVC--KVDGRYQVVEYSEI-TLATAEKRSTDGRLMFNAGNIanhFFTLTFLR-EIVrTHeP 346
XP_014343146   666 GGDCGAKVVEKTNPTEPVGVVC--KVDGLYQVVEYSEI-TMATAQKRSADGRLLFSAGNIanhYFTQSFLK-DVVtIHeP 741 coelacanth
2I5K_A         325 NLEMEI------IPNQ-KTIT-RDGheinVL--QLETACGAAIRHF--------DGAHGVVVPR-SRFLPVKTCSD---- 381 baker's yeast
XP_009435025   348 QLQHHV------AQKKiPYVDtQGQ----LI--KPDKPNGIKMEKFvfdifqfaKKFVVYEVLReDEFSPLKNADSqngk 415
WP_014259044   325 MMPLDL------IANH-KTLDpRDPdsppVI--QVETAMGSAISAF--------HTAAAVRVPR-TRFAPVKTSND---- 382 Desulfocurvib...
WP_015773692   322 MMPLDL------IINP-KSLDpRDPsspkVF--QLETAMGSAITNF--------LNAQAVIVPR-KRFAPVKTTND---- 379 Desulfomicrob...
kribb:BBB_0904 328 VLPLPV------IINN-KTVDpTDPqspaVV--QLETAMGAAIGLF--------EGAICVQVDR-MRFLPVKTTND---- 385
WP_015752000   311 FPQLPI------IVNP-KTVNpRDEnstpVF--QIETAMGAAVAAF--------PGALAVQVNR-DRFIPVKKTND---- 368 Desulfohalobi...
WP_015424819   301 LMLLPL------IVNP-KVVdg-----tpVY--QLETAMGSAISVF--------NNSKALVVSR-ERFVPVKKTNE---- 353 Candidatus Cl...
EJT43938       326 GLNLPIrsfdakIIHNnRELE--------CL--QFRTQLADCIGCF--------SSAQAMKVAR-SRFLPLTTCRD---- 382
NP_997786      347 QLQHHV------AQKKiPYVNtEGQ----LI--KPDKPNGIKMEKFvfdifqfaKKFVVYEVLReDEFSPLKNADSqdgk 414
XP_014343146   742 QLQHHV------AQKKiPYTDpQGR----VIkpD--KPNGIKMEKFvfdifqfaKNFVVYEVLReDEFSPLKNADSqdgk 809 coelacanth
2I5K_A         382 --------LLLVKSDLFRLEHGslkldpsrf--gpnpliklgSHFkkVSGFNARIP-HIP-KIVELDHLTITGNVflgkD 449 baker's yeast
XP_009435025   416 dnpttarhALMSLHHCWVLNAG--------------------GHF--IDENGSRLP-AIPrSATNGKSETITADV----N 468
WP_014259044   383 --------LLNVMSDNFILSTDyeivpnpernrspvlvdldpTFYkkVDDFQDRFPeGVP-SLLNCTTFTVRGDVrfkgg 453 Desulfocurvib...
WP_015773692   380 --------LLLVMSDCFVRTERetiipnpdrstpmpsisldeNYFkkIDAFLARFPkNPP-SLLKCDSLVIEGDVrfeeD 450 Desulfomicrob...
kribb:BBB_0904 386 --------LFIMRSDRFHLTDSyemedgnyi---fpnvdldpRYYknIEDFNERFPyNVP-SLAAANSVSIKGDWtfgrD 453
WP_015752000   369 --------LLAVWSDCYIFTPDcrivpnperrlgtivikldsTYFkkIEQLTERFQhGAP-SLVACSSLTIHGDFafgpN 439 Desulfohalobi...
WP_015424819   354 --------LLALWSDAYELNEQyqivlkrgve-kapvieldeKYYgkIEDLQKRFSkGIP-SLSECKELKIYGDVsfgeD 423 Candidatus Cl...
EJT43938       383 --------LFLLKSNLYDLDANgtfnlyplkf-gllpsiklgDEFanYETFRIGIP-HIP-DILELDYLDVMGNVffgrR 451
NP_997786      415 dnpttarhALMSLHHRWILNAG--------------------GHF--VDENGTHIP-AIP-SLKDGTDLPIKCEIsplvs 470
XP_014343146   810 dnpttarhALMSMHHRWVLNAG--------------------GHF--VDENGTRIP-AIPsS-SDRGSAALIADVhqnlk 865 coelacanth
2I5K_A         450 VTLR 453 baker's yeast
XP_009435025   469 HNLK 472
WP_014259044   454 vacr 457 Desulfocurvibacter africanus
WP_015773692   451 Vrcv 454 Desulfomicrobium baculatum
kribb:BBB_0904 454 VImf 457
WP_015752000   440 VVcr 443 Desulfohalobium retbaense
WP_015424819   424 VIce 427 Candidatus Cloacimonas acidaminovorans
EJT43938       452 VILR 455
NP_997786      471 ygge 474
XP_014343146   866 ditd 869 coelacanth
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