1OXJ


Conserved Protein Domain Family
SAM_Smaug
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cd09557: SAM_Smaug 
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SAM domain of Smaug subfamily
SAM (sterile alpha motif) domain of Smaug proteins is an RNA recognition domain. It binds a specific RNA motif known as Smaug recognition element (SRE). Among members of this group are invertebrate Smaug (Smg) proteins and vertebrate Smaug1 and Smaug2 proteins. They are involved in post-transcriptional control during early embryogenesis in animals. In Drosophila, Smaug protein is a translational repressor of mRNA of Nanos (Nos) protein. Gradient of Nanos is required for proper abdominal segmentation. SAM domain interacts specifically with the Nanos mRNA regulatory regions. Moreover, Smaug protein is involved in regulation of specific maternal transcripts degradation in Drosophila early embryo via recruitment of the CCR4/POP2/NOT deadenylase.
Links
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Statistics
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PSSM-Id: 188956
Aligned: 17 rows
Threshold Bit Score: 111.265
Created: 1-Jul-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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RNA binding
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The electropositive surface of SAM domain mediates RNA contacts. The important basic residues were identified based on genetic and structural analysis of SAM/PHAT domain complex of Smaug protein.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                         # ##                           #  ###      # # 
1OXJ_A          2 THMVGMSGIGLWLKSLRLHKYIELFKNMTYEEMLLITEDFLQSVGVTKGASHKLALCIDKLKE 64   fruit fly
XP_002170483  293 NAHPGMKDIPLWLKSLRLHKYAHIFTDVTYEEMMSFSDEYLEKHEVTKGARTKILLCIQKLKD 355  green hydra
XP_002432906  270 SDIPGMRDVGTWLKALRLHKYIWLFAQLSYDEMLALTEEKLEAAGVTKGARHKIILSIRKLKD 332  human body louse
XP_002410201  424 FSSGWCADVPGWLKSLRLHKYAYLFANMSYDEMMNLTEDKLEAQNVTKGARHKIVLSIRKLKE 486  black-legged tick
XP_392982     290 SLASGMRDVPSWLKTLRLHKYSYLFVTLSYEEMLQLTEEQLAEQGVTKGARHKLALSIAKLQQ 352  honey bee
XP_001187902  974 EEKSGMKDVPTWLKSLRLHKYTSLFESIDYNEMMALSERQLEEMDVTKGARNKIMLSIHKLKE 1036 purple urchin
EFA02097      266 SNLPVMKSILSWLKSLRLHKYSWVFHNLTYQQMLDLSDESLQTIGITKGARHKLLLSIAKLKE 328  red flour beetle
XP_001640702  221 SYGNYNSDVPMWLKSLRLHKYGSLFSQLSYEEMLNLSDEYLESKGVTKGARNKILLSTRKLQE 283  starlet sea anemone
XP_002109039  236 MPAMSKTSVPAWLKSLRLHKYSHLFAHFSYSEMLNLTEDELERKNVTKGARNKILVNIKKLPD 298  Trichoplax adhaerens
Q5PRF9        296 EDGSGMKDVPSWLKSLRLHKYAALFSQMSYEEMMTLTEQHLESQNVTKGARHKIALSIQKLRE 358  human

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