6CBC


Conserved Protein Domain Family
Chorein_N

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pfam12624: Chorein_N 
N-terminal region of Chorein or VPS13
Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.
Statistics
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PSSM-Id: 463646
Aligned: 175 rows
Threshold Bit Score: 62.583
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6CBC_A           2 LEGLVAGLLNRFLGXYV--KNFDPKQLKWEV-WNG--KVRLDNLELQREALDQ-L--KL--P--INVIKGHLGHLVLHIP 69    Chaetomium ...
EGI67715        14 KKRACRYLLQRYLGQFL--EELTLDQLTVDL-YNG--TGRVVNVSLDVQALNE-MgeQQhlP--LEFVDGFIMEISLSIP 85   
XP_002427653    12 AKSVCKYLLQRYLGQFLe-EKLTLDQLTVDL-YKG--IGIISDVVLDVQALNE-VaeQQniP--FEFIDGFIEKMSVSVP 84   
XP_002027746    11 KTKMCRYLLQRYLGQFFe-NNLNLEQLKVDL-YNG--RAVVENISLKVNAFND-LfeDQgwA--FEVVSGHIGCLTVAVP 83   
Q17EJ5          12 KKKVCRFLLQRYLGQFIe-EKLSLDQLKVDF-YNG--TGTVSDVTLYCQALND-LceGQgwG--IEVICGHIGEVTVNIP 84    yellow feve...
Q23F63          26 VETLVKNIVQKYLGQYVdiKQFQLKSIQ-DI--------SLENVNLKIEEINS-KilYKs-P--FIMTYGQIGKMKIQIP 92    Tetrahymena...
Q54T12          24 LNKILRSLINKHIKSLLv-NPIQKSEFETRIlESH--NVKLKNVVFDQEKLKPkL---VglPfsFGMIK--VAEIELTIP 95    Dictyosteli...
ESS35768         6 LDQLIKTYGHEFLGDWDpiNNFRIDSL-----AEP--EVHLTNIPFPQQLFDL-A--EI--P--FAVDYSNIAKVRAKFS 71   
XP_002139180     9 TEKILYSAVRNAFDSIF--VNFEREQLSASL-TRG--CFEIRSLNIKRELFDG-I------PfpIRLCDALVGKARIEIS 76   
RLN83594         2 LEGALKSWIIYFLGQYVesHSV---NVSAKL-WQSseRLKLENLTLKASVVPSwL------P--FRLKAGFIGLFEADLP 69    Phytophthor...
6CBC_A          70 WKTLAS----EQ-VKINIEDVFLLAspk--eeaEYDEDE--EARRRH---------RLKXEKLDS 116   Chaetomium thermophilum va...
EGI67715        86 WSALLS----QA-SYVEVKGLRLTVqprq-rieTGTSMF--ESMWSS---------MTSSMQLAQ 133  
XP_002427653    85 WSSILT----DA-TNIEVEGLSLTIknve-rdkTRVSMI--ESMWSS---------MTTSLQLAE 132  
XP_002027746    84 WNALMT----ND-SSLEISNLTITLrpvt-rfqSGTTML--ESMWSS---------VSSSMQMAE 131  
Q17EJ5          85 YEAPLA----KD-SSIEVKNLSISLrpka-rvtDGTSMF--ESMWSS---------MSSSMQLAQ 132   yellow fever mosquito
Q23F63          93 IQDLLT----KQ-SKAEINQVEIHLrpng-kniSHNYFR--KQENKE---------KSDTQKLQE 140   Tetrahymena thermophila SB210
Q54T12          96 LDDIYN----KP-LSIKINGLEIEImpvdinfnNNNNN---NNSNNN---------NNKNNSSLN 143   Dictyostelium discoideum AX4
ESS35768        72 WQTFFGspssNP-FTIEAEDLEIRL-------------RllYPSEWDaehwlakvlKAKRKRIDL 122  
XP_002139180    77 WTKFFS----GGfLTIILQDIYIIFnti--dikEWDVEI--CEKSWS---------NLKSKLLQQ 124  
RLN83594        70 ISAIFG----SAsAKIKFQDVLLVLsplq-hddEEIQE---EIAALV---------DQKMARLEQ 117   Phytophthora kernoviae
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