2BYV,1NVV


Conserved Protein Domain Family
REM
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cd06224: REM 
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Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately N-terminal to the RasGef (Cdc25-like) domain. REM contacts the GTPase and is assumed to participate in the catalytic activity of the exchange factor. Proteins with the REM domain include Sos1 and Sos2, which relay signals from tyrosine-kinase mediated signalling to Ras, RasGRP1-4, RasGRF1,2, CNrasGEF, and RAP-specific nucleotide exchange factors, to name a few.
Links
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Statistics
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PSSM-Id: 100121
Aligned: 89 rows
Threshold Bit Score: 53.1852
Created: 8-Jan-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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GTPase
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:GTPase interaction site [polypeptide binding site]
Evidence:
  • Structure:1NVV: Human SOS binds Ras, contacts calculated at 3.5 A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 #                                                                    
2BYV_E     492 TPEKILEHFLETirlepslneaTDSVLNDFVMMHCVFmpnTQLCPALVAHYhaqpsqg------------------teqe 553  house mouse
1NVV_S      40 TVIKLIERLTYHmy-------aDPNFVRTFLTTYRSFckpQELLSLIIERFeipepepteadriaiengdqplsaelkrf 112  human
O15211      96 TLEALVRHLLDTrts-----gtDVSFMSAFLATHRAFtstPALLGLMADRLeales-----------------------h 147  human
Q9NZL6      73 TLEKLVENLLTAfg------dnDFTYISIFLSTYRGFastKEVLELLLDRYgnltspnce--------------edgsqs 132  human
Q12967     120 TLEKLVEHLVPAfq------gsDLSYVTIFLCTYRAFtttQQVLDLLFKRYgrcdaltassry--------gcilpysde 185  human
Q7RYJ8     607 TFDELIDRIIAPkmt-----raDNNFADIFLCLYRKFatpCELMSALLSRLdrlrdg--------------------tdm 661  Neurospora crassa
Q5TPG0      66 TLSRLVDALATDdg------elESTFVNVFLNTFRTFaqpEKVLELLLDRYeklhaep------------------allq 121  Anopheles gambia...
Q8BVR5      74 MVVKLVNNLVPSlq------egDHFFVSIFLSTYRSFvtpLQVLGLLFMRYpyfh------------------------p 123  house mouse
Q9DE48      52 TEEKLVLHLLHSfs------mgDSSFISIFLSTYRSFtstQRVLDILICRLenppg----------------------et 103  zebrafish
Q6P112     109 TLERLVETLLTAfg------dnDLTYTSIFLSTYRAFastQSVLELLLDRYgsfedcege---------------rsqcq 167  zebrafish

Feature 1           #   ##  #  ##                                          ##  #      #
2BYV_E     554 rmdYALNNKRRVIRLVLQWAAMYgdllq---eddvAMAFLEEFYVSVSdda-----rmMAAFKEQLPELEKI 617  house mouse
1NVV_S     113 rkeYIQPVQLRVLNVCRHWVEHHfydfe---rdayLLQRMEEFIGTVRgk-------aMKKWVESITKIIQR 174  human
O15211     148 ptdELERTTEVAISVLSTWLASHpedfg--seakgQLDRLESFLLQTGyaag---kgvGGGSADLIRNLRSR 214  human
Q9NZL6     133 sseSKMVIRNAIASILRAWLDQCaedfre-pphfpCLQKLLDYLTRMMpgs-----dpERRAQNLLEQFQKQ 198  human
Q12967     186 dggPQDQLKNAISSILGTWLDQYsedfcq-ppdfpCLKQLVAYVQLNMpgs-----dlERRAHLLLAQLEHS 251  human
Q7RYJ8     662 pslLSIESQMRVIEVVAKWLSLYpgdf----artaTRRRLEGLISDLAtnevfsaaarQMKGNLEQKVVDDD 729  Neurospora crassa
Q5TPG0     122 pesLSDQHKKTLVSVLHVWLDGFpedw-----dtdNLQRLLAFTSKRLpk-------sEIHMKALNRNSKRT 181  Anopheles gambiae str. PEST
Q8BVR5     124 hsvEHRQVRSSLCNFLHTWMDKNpedfcd-psdmlPLTYLKAYLSVHMphs-----elFIRVDRLLNELWEE 189  house mouse
Q9DE48     104 hsnSRQIFNKAVCTVFSTWMTDYpedfrslsdpsrLLRLAPLLPTDSSg---------AEIKSRLLRIAEEL 166  zebrafish
Q6P112     168 tgeSRKAVRKALASILRAWLDQCpedfqe-ppsypSLHRVLGFLQKAMpgs-----epMRRAQSLLEQLRVQ 233  zebrafish

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