Conserved Protein Domain Family
SLC6sbd_GAT3
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cd11508: SLC6sbd_GAT3 
Na(+)- and Cl(-)-dependent GABA transporter 3; solute-binding domain
This family includes human GAT3 (hGAT3) a high-affinity transporter of gamma-aminobutyric acid (GABA). GABA is the main inhibitory neurotransmitter within the mammalian CNS. hGAT3 is encoded by the SLC6A11 gene, and is similar to mouse GAT4, and rat GAT3/GATB. GAT3 is expressed primarily in the glia of the brain, and is a potential drug target for antiepileptic drugs. This subgroup belongs to the solute carrier 6 (SLC6) transporter family
Links
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Statistics
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PSSM-Id: 212077
Aligned: 4 rows
Threshold Bit Score: 1044.57
Created: 20-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:Na binding site 2 [ion binding site]
Evidence:
  • Comment:based on Aquifex aeolicus LeuT (SLC6) with structure
  • Comment:One of two Na+ binding sites in Aquifex aeolicus LeuT. It binds the Na+ ion designated Na2, and appears conserved in Vibrio parahaemolyticus vSGLT and other SLC5 proteins
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                     #  #                                                            
NP_055044  49 ERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPL 128 human
CAA60635   37 ERGHWNNKIEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVIFFIGCGIPVFFLETALGQYTSEGGITCWRKICPL 116 marbled electric ray
XP_414302  37 ERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPL 116 chicken
AAA41183   44 ERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRRVCPL 123 Norway rat

Feature 1                                                                                     
NP_055044 129 FEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENCVEFQKLNVsnyshvsLQNATSPVMEFWE 208 human
CAA60635  117 FEGIGYATQVIEAHLNMFYIIVLAWAIFYLFNCFTSELPWATCGHYWNTENCLEFQKLNStncnhtaVPNATSPVIEFWE 196 marbled electric ray
XP_414302 117 FEGIGYATQVIEAHLNVYYIIILAWAIFYLFNCFTTELPWATCGHDWNTENCVEFQKLNMsncsqisLQNATSPVMEFWE 196 chicken
AAA41183  124 FEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTEKCVEFQKLNFsnyshvsLQNATSPVMEFWE 203 Norway rat

Feature 1                                                                                     
NP_055044 209 HRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYP 288 human
CAA60635  197 RRVLGLSRGIEHIGRVRWELALCLLAAWIICYFCIWKGPKSTGKVVYVTATFPYLMLLVLLIRGVTLPGAAEGIKFYLYP 276 marbled electric ray
XP_414302 197 RRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLMILLIRGVTLPGASEGIKFYLYP 276 chicken
AAA41183  204 RRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYP 283 Norway rat

Feature 1                                                                                     
NP_055044 289 DLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIA 368 human
CAA60635  277 DVSRLSDPQVWLDAGTQIFFSYAICLGCLTALGSYNPYHNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAFEQGVPIA 356 marbled electric ray
XP_414302 277 DISRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIA 356 chicken
AAA41183  284 DLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIA 363 Norway rat

Feature 1                                          #  ##                                      
NP_055044 369 EVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGyRRELLILALSVISY 448 human
CAA60635  357 EVAESGPGLTFIAYPKAVTMMPLAPLWAFLFFLMLIFLGLDSQFVCMESLVTAIIDMYPSIFRRGyRREQLIFVIALASY 436 marbled electric ray
XP_414302 357 EVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGyRRELLILGLSIVSY 436 chicken
AAA41183  364 EVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGyRRELLILALSIVSY 443 Norway rat

Feature 1                                                                                     
NP_055044 449 FLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIF 528 human
CAA60635  437 LMGLVMVTEGGMYIFQLFDAYASSGMCLLFVAIFECICIGWVYGGNRFYDNIEDMIGYRPFVLIKWCWIFITPGICAAIF 516 marbled electric ray
XP_414302 437 FIGLIMLTEGGMYVFQLFDSYAASGMCLLFVAIFECVCIGWVYGSNRFYDNIEDMIGYKPLSLIKWCWMVITPGICAGIF 516 chicken
AAA41183  444 FLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECVCIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKVVTPGICAGIF 523 Norway rat

Feature 1                                                                   
NP_055044 529 IFFLIKYKPLKYNNiYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTP 590 human
CAA60635  517 IFFIVRYQPLKYNNvYVYPDWGYALGWALALSSMICIPLGFIFKMWSTEGTFLEKIKKLTTP 578 marbled electric ray
XP_414302 517 IFFLVKYKPLKYNNvYTYPDWGYGIGWLMALSSMICIPLWICIKFWKAEGTFIEKFRKLITP 578 chicken
AAA41183  524 IFFLVKYKPLKYNNvYTYPAWGYGIGWLMALSSMLCIPLWIFIKLWKTEGTLPEKLQKLTVP 585 Norway rat

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