Conserved Protein Domain Family
Folate_carrier

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pfam01770: Folate_carrier 
Reduced folate carrier
The reduced folate carrier (a transmembrane glycoprotein) transports reduced folate into mammalian cells via the carrier mediated mechanism (as opposed to the receptor mediated mechanism) it also transports cytotoxic folate analogues used in chemotherapy, such as methotrexate (MTX). Mammalian cells have an absolute requirement for exogenous folates which are needed for growth, and biosynthesis of macromolecules.
Statistics
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PSSM-Id: 460318
Aligned: 17 rows
Threshold Bit Score: 393.961
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9BZV2    10 SSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGPDKNLTSAEITNEIFPVWTYSYLVLLLPVFVLTDYVRYKPVIILQGIS 89  human
Q9EQN9    28 ECWFLPTALLCAYGFFANLRPSEPFLTPYLLGPDKNLTERQVYNEIYPVWTYSYLLLLFPVFLATDYLRYKPVILLQGLS 107 house mouse
EDO34856   6 EFWQKATLLLCLYGFFKEMKPSEPFLTPYLRAPPKNITDEQLENEIYPVWTYSYLAALFFVFVFTDFLRYKPVIIIEGLA 85 
O45166     2 EQW-KVMVLICMYGAVKEFRPTEPYMYEYQHTV-LNMSEQTLNSQVYPIWTYSYLITLIPAFLLTDVFLYKPLLVFEAFS 79  Caenorhabditis elegans
Q9VK64     2 KSWLKISLLLCTFGFFREFRPSEPYVTEYLASDYGNLTTDQIYQDVYPFGTYSVLAQLVIVFLITDLVRYKPVIVLSALA 81  fruit fly
Q9VGV5     2 KEWLKISCLLCVFGCIREIRPSEPYVTEYLLGPWRNITEQQLTHDVYPVGTYSYLVQLVFVFLITDFLRYKPLIITIGAA 81  fruit fly
Q9VGV6     2 ESWLKISCLLCIFGFLRELRPSEPYHAEILMGEWYHVTQDEVNRSVYPVGTYSYLALLIFVFLITDLLRYKPVIIANATT 81  fruit fly
CAF91078   6 ENWKYPTFILCIYGFFSTVRPIEPFLFAYLTGPDKNLTAEELNNQIFPMSTYGNLAAQIPIFLLTDWLRYKPVVILECVA 85 
Q1LV16     4 SDWVFPTVLLSLYGFFANCRPAEPFLTPYLVGP-KNISEEVVTNYLFPIWTYSYLSLLCPVFLLTDLLRYKPLIVAQGLF 82  zebrafish
Q28C92    10 SGWKYPTILLCLFGFFADMRAVDPFTAQYFTGSYHNLTVEQVKNSVLPVWTYSYIALLIPVFLLTDYLRYKPIIVLQALG 89  tropical clawed frog
Q9BZV2    90 FIITWLLLLFGQGVKTMQVVEFFYGMVTAAEVAYYAYIYSVVSPEHYQRVSGYCRSVTLAAYTAGSVLAQLLVSLANMSY 169 human
Q9EQN9   108 LIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYYSYIYTVVDLGMYQKVTSYCRSATLVGFTVGSVLGQILVSVVGWSL 187 house mouse
EDO34856  86 YLATRVLLIWASGVLAMQFMQLAYGIATGAEVAYYSYIYAVVDIEHYLKVTSYTRAAVLVGRMMSGVVGQLLVSFRVCDY 165
O45166    80 YFLCWVIFVFGKSVWSQQVLEVFYGWATATEIAYFAYIYVKVPKTEYKSATAFTRAALLVGRFLAYALAQLLIGLNWTSY 159 Caenorhabditis elegans
Q9VK64    82 GITLFSMLIWTETVGMLQVAQVFFGTFTAAEVAYYTYMYAKVNKEQYQVVTGHTRAAILSGKFLGGLFAQILVSTDSMDY 161 fruit fly
Q9VGV5    82 GVIIWSMLIWTTSLLSLQILEFFFGTYMAAEVAYYTYIYAKVDKKYYARVTSHTRAAMFAGKLVSGITSQLMLNLELMNY 161 fruit fly
Q9VGV6    82 GICIWGTLIWTTTLSGLQAVEVFYGFYQAGEVAYYSYIYAKVDKQYYPRVTSHTRAAMFVGKLVAGILAQMVIGMRWMNY 161 fruit fly
CAF91078  86 LFTTTALNLWTASVPGQQASEFFFGVATASEVAYYSYIYSMVPVNKYRKATSYVRSVQLLGYTVGAVLAQLIFSFKLLSF 165
Q1LV16    83 LVTNYIILSFANSLPALTYLQFNFAVVTSTEVAYFSYIYSVIPPERYQRATGYVRSAMLAGYTFGAILGQMLISLANTSY 162 zebrafish
Q28C92    90 LSISMLLMLITRGEAAMQGMEFAYAIFSSCDVAYYSYIYSMVDIVYYQRVTSYCRSITLVAATLGALLQQILMSFAGVSY 169 tropical clawed frog
Q9BZV2   170 FYLNVISLASVSVAFLFSLFLPMPKKSMFFHAKpsreikksssv---npvleethegeAPGCEEQKPTSEILsTSGKLNK 246 human
Q9EQN9   188 FSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIpsschgvnglkvqnggivtdtpaanHLPGWEDIESKIPL-NLDEPPV 266 house mouse
EDO34856 166 LTLNYISMASVCIAFIFTFLLPSATGNVFGVGQni---------------------pqNTDSKADGNCDDEIiVVHKLPG 224
O45166   160 STLNIISLVAMTIAVFLALILPGVEWKEAYEKK--------------------------------------LeDNNVQGN 201 Caenorhabditis elegans
Q9VK64   162 RQLHYLSLATQLISLAVSLFLPSVPRSLYFYAG-------------------------------------------SEKI 198 fruit fly
Q9VGV5   162 KELNYITLGTQIIAMLWAFGLPRVDRSLYFHRE------------------------------QLSITEPQT-QLPGVGN 210 fruit fly
Q9VGV6   162 KQLFYITVTSQVAALLWAFFLPKVEKSLYFHNR-------------------------SEAIEGGTKSDGGNlEKGSEQP 216 fruit fly
CAF91078 166 NNIAILTLILLAIGLFTSFLLPVPQWSMFFHKKtkvtd---------------lefpgELNTKHVERTGEIKdKGEETAN 230
Q1LV16   163 FHVNTVTLSLMIVALCISLSLPMPQHGVFFKKK-------------------------QVEVSMDTMNEVADgGSSRDLE 217 zebrafish
Q28C92   170 FYLNILTLTSALVSLVCSMFLPVPSRSMFFHKKmpgdt----------------ilskQARSPKMETTEDTN-------M 226 tropical clawed frog
Q9BZV2   247 GQLNSLKPs--nVTVDVFVQWFQDLKECYSSKRLFYWSLWWAFATAGFNQVLNYVQILWDYK-APSQDSSIYNGAVEAIA 323 human
Q9EQN9   267 EEPEEPKP----DRLRVFRVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYAQGLWEKV-MPSQNADIYNGGVEAVS 341 house mouse
EDO34856 225 S--LNNCGrlynSWKLSLLNMWHDFKVCYSNKELLKWSLWWSFGTCGEFQVENFIQNLWEVIyPSMSHRKIYNGGVTAIS 302
O45166   202 LKEIVDQSsymdYLRMFFVGLRHNLMAIYRNPLILKWSVWSALSSCIFYQVTNYTQTLWGTL---PESANRYNGITEALV 278 Caenorhabditis elegans
Q9VK64   199 TIADGEETspkfSFANACRLLWYHLVSSYSNPVVLQWSIWWALATCGQVQVISYIQFLWKEV--APNKLSVYNGGVEAVA 276 fruit fly
Q9VGV5   211 LAEMDQQQentqKQPGALSLLWLHFRNAYTNPRVVQWSLWYAIGLAGYLQVTYYVQVLWKVI--EPEPVIAWNGAVDAVL 288 fruit fly
Q9VGV6   217 SN----EEasqeKKIPALQLLWSHFRSAYTNPLVIQWSLWYAISLAGFLQITTYMQVVWKSF--ENEPTIAWNGAVDVAL 290 fruit fly
CAF91078 231 TTEDPQELaveqTCGKVLLKMIRDSRDSFSSRKLLYWSLWWVMATCGFTQIVSFVQSLWEHV-QPSQNASIYNGGVEAVS 309
Q1LV16   218 KEVTGRSVkiceYIKTSGKQMWESLKESYSSRRLVQWSLWWALATAGYGQVFNYVQLMWDHI-EPSSTSSVYNGGVEAVC 296 zebrafish
Q28C92   227 LKGCEAERasntNFFNVIWLLCKEVKECYWSRKILYWSLWWAFATPIYNLLVNYSQLLWVYV-EPSGKINAYNSAVDAAS 305 tropical clawed frog
Q9BZV2   324 TFGGAVAAFAVGYVKVN--WDLLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVE 401 human
Q9EQN9   342 TLLGASAVFAVGYIKLS--WSTWGEMTLFLCSLLIAAAVYVMDTVQSIWVCYASYVVFRIIYMVLITIATFQIAANLSME 419 house mouse
EDO34856 303 HLFCVGVALLLSRLNVN--WSIFGEVVLGIVCVADAFVLYISAHTSSLWLAYLMYILFRVAYTFLITIASFQIAKNVGLS 380
O45166   279 PLLGIPADLITRQLNVN--WNRWGDLLLAVGSIGQAGLLFWMSQSHHIVVLYLSYIFYRVIYQLTTTIAQSTLAFSLDSR 356 Caenorhabditis elegans
Q9VK64   277 TLLGAIGAILAGLLNSNkrRGSY-MMGISICAAALGALLIYAAKTQLIWVAYVNYVLFCTVFFFIITVAGAVVAENLVED 355 fruit fly
Q9VGV5   289 TALAALSALAAGYLHTGrlRPRASLLILGILSAVEGGCVLICCWTQDIYWSYAGFVLFGALYGFTITVASAEVARNLEEE 368 fruit fly
Q9VGV6   291 TLLSAVFALLAGYFHAGrlNTRSSLLSMALLSVLEGGCVLLSCWTDDIYLSYLGYVLYGGLFAFTITVASSELASSLEED 370 fruit fly
CAF91078 310 NLLSAATVYAIGYKEDR--WERWEELALGAFSGLCSGALFVMTFSNNIWVCYVSFVIFKCLYMVLMTLAMFHIAIGLTME 387
Q1LV16   297 ALVGAAAAFSVGYIQVQ--WGVWGELSLGVFSAVGAGCVFLMGLTNSIWLSYAGYAIFKASYMFLITITMFQIAVNLSME 374 zebrafish
Q28C92   306 TFLGAILSMGAGFVKVD--CELFGEAALTCLSIIDAGVLLFMGFSRTVWISYAGYLIFKSSYMLLITIATFNIAVNLSME 383 tropical clawed frog
Q9BZV2   402 RYALVFGINTFIALVIQTIMTVIVVD-QRGLNLPVSIQFLV 441 human
Q9EQN9   420 RYALVFGVNTFIALALQTLLTLIVVD-ARGLGLCITTQFLI 459 house mouse
EDO34856 381 RFALVFGCNMFAALALQTILTTIVAD-KSGLDLNIIEQFVV 420
O45166   357 LFGLLFGINTFVALLLQSILTAVVID---WQKLDIRPQFVV 394 Caenorhabditis elegans
Q9VK64   356 SFGLIFGINTLVGLILQTILTVAVVE-RVGFALEPRDQYVV 395 fruit fly
Q9VGV5   369 SFGLVFGVNTFVALIFQSLLTIIFVT-DTGFELDPVGQYTA 408 fruit fly
Q9VGV6   371 SFALVFGFNTFVGLLLQCILTFVVVSeKANLNLNVFQQFSV 411 fruit fly
CAF91078 388 RYALVFGANNFSAVVLQTILTSIVVD-KGGLGLSIIPQFIV 427
Q1LV16   375 CYALTFGINSFVALTLQTILTAIVVD-NTALGLDIATQGLY 414 zebrafish
Q28C92   384 RYALLFGFNTLVALFIQTLLT-VVVD-HRRLGLDLITQFLV 422 tropical clawed frog
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