6C26


Conserved Protein Domain Family
OST3_OST6

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pfam04756: OST3_OST6 
OST3 / OST6 family, transporter family
The proteins in this family are part of a complex of eight ER proteins that transfers core oligosaccharide from dolichol carrier to Asn-X-Ser/Thr motifs. This family includes both OST3 and OST6, each of which contains four predicted transmembrane helices. Disruption of OST3 and OST6 leads to a defect in the assembly of the complex. Hence, the function of these genes seems to be essential for recruiting a fully active complex necessary for efficient N-glycosylation. These proteins are also thought to be novel Mg2+ transporters.
Statistics
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PSSM-Id: 461420
Aligned: 173 rows
Threshold Bit Score: 112.339
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6C26_3        26 NRLLKLANKSp-------KkIIPLKD-SSFENILa---PPHeNAYIVALFTATAPEIGCSLCLE-LESEYDTIVASWFDD 93  Saccharomyces c...
XP_013630911  38 NELVSLRSNSe-------SgVIHLDD-HGISKFLisspTPR-PYSILVFFDATQLHSKTELRLQeLRREFGLVSANFLAN 108
XP_018509225  30 KELVSLRSSSe-------SgVIRLTD-DTVSKFItsvsTPR-PYSLIIFFNSIDLNSNP---LQeFRREFAFVSASFIAN 97 
XP_002889874  32 NELVSLRSAAe-------SgLIPLND-EDVSKFItsvaTPR-PYSLIIFFDAIHLHGNSQLRLPeFRREFGLVSATFIAN 102
XP_005849823  28 QRLLALQRSH--------GgVIELDP-KTFQELLvg--kSR-PYSVIIVADAKDLRSQGKLKLGqLVSEFRLVAKSFAAT 95 
CBN74884      45 RSLEKLRAAGdskgqaggGaVVVVDG-TKFDRYItg--vPR-QYEAVVFFTAAGANYKCTSCRV-HLDEFTTMAESYQAA 119
6_pfamImport   1 EKLAKLQQRAr-------NgVVPFTS-DLFTRFAv--rPER-PYHLVLLLTATSAKHKCDACLQ-LAPEFELLGQSYQAA 68 
EGC30798      49 KEFRDLAVKE--------GgIIQLKTlTQTKKFLqa--kNR-PYEVLALFTSSNPKYGCAGCLV-L-----NYGASYIQY 111
Q54N33        46 NDLYDRAKKA--------GgVVEFKSnLDSKKFVta--qNR-PYDLLALFTSSNPKYGCSGCVQ-LKNQIESFSLSYEPY 113 Dictyostelium d...
XP_001022369  30 EALRELASKSp-------NgIIHFNS-TGYRYFLl--eQPR-PYEVVLFFTAP----KCDFCEQ-MLTQYELTSNYYYAN 93 
6C26_3        94 hpd-----akSsNSDTSIFFTKVNLedpsKT-IPKAFQFFQLNNVPRLFIFKP---NS-PS-ILDH----SVISISTDTG 158 Saccharomyces c...
XP_013630911 109 n--------nG-SDLNKLFFCEIEF----SR-SQSSFQRFGVNALPHIRLVSG---STsKLsDESG----QMDQSDFAR- 166
XP_018509225  98 nnnr---sdvA----NKVFFCEIDE----SS-DSEAFGLFGIQFLPQICLVDP-----------------LMENLQDKTG 148
XP_002889874 103 nn-------nG-TNGKKLFFCEIES----TH-SVASFQRFAVENLPHISLVSP---MTeNL----T----ESDQMDGGDF 158
XP_005849823  96 hag----kgsV----GSVIFARLEF----SK-AKDLFGRMGIQALPYLARIPP----------SLAisegGAVTLGKEEV 152
CBN74884     120 rantp-etlnG----VDVYFFVADF----GQ-NQLPFQKLGLQTVPKILHFPP------------AlaegDDGRYAIDQS 177
6_pfamImport  69 aqvkvdtrdgL-----DVVFGVADY----EA-NQEVFRHYELTSAPFVVYVAPdanSDvGAaLPTKeqvnPQYLYNVYTQ 138
EGC30798     112 lesp---qflE----KPIFVVILEV----DS-TLEFFQHVGFNTIPHLVFIPS----------GSKpiqtKGFTFT---- 165
Q54N33       114 lnsa---gflE----KPIFIVILEV----DY-NMEVFQTIGLNTIPHLLFIPS----------GSKpitqKGYAYT---- 167 Dictyostelium d...
XP_001022369  94 nghip-fkdsS-KKLRAVYFGMMSF----DQnTRETFLDLEFKSVPNLLVSVP---QHaLVsDQERnnflKGFKWSISGS 164
6C26_3       159 ----SE---RMKQIIQAIKQFSQv--NDFSLHLPM-DWTPIITSTIITFITVLLFKKQSKLM--F-SI--ISSRIIWATL 223 Saccharomyces c...
XP_013630911 167 ---------LAESMAEFVEQRTKl--TVGPIQRPP-FLSKAQISVIVAMIVIATPFVIKRILkgE-TL--LHDRRLWLSG 231
XP_018509225 149 rmeeEDvdgTAESVVEFIESRTNl--TVGPLHRPP-LLSKTQISVIVALIAISTPFLIKKVL--K-GEtvLHNSRVWLFC 222
XP_002889874 159 ----TG---LAESMAEFVERLTKl--TVGPIQRPP-LLSKTQIGIIVAFLIISTPILIKKILkgE-TL--LHDRRIWLVG 225
XP_005849823 153 mpttGYp-wSAEAIAEWVLERSGv--AVGEIKRPT-LISTRLMPLLSLAVLACVAFVGYHLY----YAsfMRHQWLYALG 224
CBN74884     178 qhmhMAgqvKAEDMARFVKEKTG---VSFPIIRP--EPPVMIILVGLLVVAALAIKPILSNLgaLlRV--IRNKYLWLAT 250
6_pfamImport 139 ----GL---QAEGMATFVHQRTG---FEVTVLRSK-TYLYVLVAVASVGVAIAAKLALDHLD--F-LLmkLRRKQLWMTV 204
EGC30798     166 ----KVdqaTPAQISNFILSHSKiniEPVRTLYE--KYSQQFFGTIIFIASLRFIITAYKKR---------NNPMFWYFL 230
Q54N33       168 ----GFeqtSSQSISDFIYSHSKiriEPVKTFYE--KYSVQILSFVVFLASVRFLITAYRKR---------KSPMFWYFL 232 Dictyostelium d...
XP_001022369 165 ----DGl-vTHHKLLEYINKRTG---REIEYQPPIhEVLRNLGILLILIILTIVVFRLYKSF--------FLNTKLWFVG 228
6C26_3       224 STFFIICMISAYMFNQIRNTQLAGVGPKGE--V-MYFLPNEfQHQFAIETQVMVLIYGTLAALVVVLVKGIQFLRShlyp 300 Saccharomyces c...
XP_013630911 232 AIFIYFFSVAGTMHNIIRKMPMFLQDRNDPnkL-VFFYQGS-GMQLGAEGFAVGFLYTVVGLLLAFVTNVLVRVRN---- 305
XP_018509225 223 TVLVYFFSVSGTMHNIIKGMPMFVRDHEDSn-KlVFFYKGE-NFQLGAEGLSVGLLYNVVGLLLAYVTNALVRVRS---- 296
XP_002889874 226 AVFVYFFSVSGTMHNIIREMPMYIKDYEDSnkF-VFFIEES-EMQLGAEGFFVGFLYTVVGLLLAFVTNVLVRVKK---- 299
XP_005849823 225 AIAVYWFSVSGGMFNIIRGVPLVGFDHRKRq-S-MLFMPG--QGQLGAEGFIMGSLYTTVGLAVAALIILAPKVKD---- 296
CBN74884     251 SLLVYTFGISGGVYDIIRNPAPFMVKQDGF--I-MWFHPQS-NVQFVAEGFITGIMTLMCGLSGILLVHVAPKLRN---- 322
6_pfamImport 205 SLLFYGLSVSGMVYCIIRNPPPYAADRQGN--V-QYFHPQG-RQQFVYEGLIVGSYDVAAAVCVILLSQWALYVRN---- 276
EGC30798     231 TILLFSAVIMGIFYDFIHKPALYDYDHRNQk-Y-NYFSRGS-RSQTVSEGFIMGVSTLAITLVFIYISDILPNYSRfg-- 305
Q54N33       233 TILLFACVIMGIFYDFIHKPNFYEFDHRQQt-Y-NYFSRGS-RSQTVSEGMIMGVSTIAITLIFVFLSDILPNYTNfs-- 307 Dictyostelium d...
XP_001022369 229 SIVIYFVCIAGFIYNQIHGVPMTTVDSKGN--F-QWMLDNQ-RMQLGAEGFVMSGL-IILSALTIISYQLIARLNQk--- 300
6C26_3       301 etkkaYFIDAIL-ASFCALFIYVFFAALTTVFTIKSPAY----------PF 340 Saccharomyces cerevisiae S288C
XP_013630911 306 -----LNVQRLV-MLVALFVSFWAVKKVVYLDNWK-TGYgi-------hPY 342
XP_018509225 297 -----VSGQRVF-MMLAMVVSLLAVKKVVYLNSWK-TGYeiqtywpsswH- 339
XP_002889874 300 -----LEEQRMA-MLLSLSISFWAVRKVVYLDNWK-TGY----------EI 333
XP_005849823 297 -----PNTQRVA-AYGIILVAFMAFRLVTSNHLWK-TGMntdwylf----- 335
CBN74884     323 -----SGYRQVA-VCVCGVIFLMLFSKVMSLYKSKNMWYr---------PV 358
6_pfamImport 277 -----PVVRYLA-IVGCSLGFVFLYRQMTDAYKMKNRWYtgwmgf------ 315
EGC30798     306 ----tKVKNVLFfLGMGAIISFLYFQSI--AFSMK---Yy--------rPL 339
Q54N33       308 ----sKSKGLLFfMGMSSIIVLLFFQSL--AFQIK---Yy--------rPL 341 Dictyostelium discoideum
XP_001022369 301 -----NIVNQLL-LIAIFGTTFIIVIKIEELYKFK-GWY----------NI 334
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