Conserved Protein Domain Family
COA8

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pfam10231: COA8 
Cytochrome c oxidase assembly factor 8
Apoptogenic protein 1 (Apop1, also known as cytochrome c oxidase assembly factor 8), previously thought to induce apoptosis through the Cyclophilin-D-dependent pathway, is required for cytochrome c oxidase (COX) assembly and function. Apop1 is controlled by the ubiquitination-proteasome system (UPS). In Drosophila melanogaster, Apop1 is also involved in neurological impairment, COX enzymatic activity, and resistance to oxidative stress conditions.
Statistics
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PSSM-Id: 463011
Aligned: 32 rows
Threshold Bit Score: 152.409
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EPS98567      20 RHlVGPSDPVSNLRPVIYDdaVPEHRTDLthpyslrefggdtrEYQWKMQRQQLDAYNHVFWTDCNLRFGAAKQAVLDSL 99 
ESO02537       2 HDwIGPADKVSNLRPLKFY--KKKRESKR--------------EEELRIFREDTQAWNQEFWRKHNDNFTMMKKEYIKE- 64 
EEC13752       8 ATlVSPPDPVSNLRHVKLR--IPENESPA--------------EAQFRMQYAAVQDWNQEYWTKHNTDFQRKKDEFTRRK 71 
EFX71456      44 TDvYGPPDPKSSLRLITFY--IPPDETEA--------------EKKYRLRRAQVQEWNHLFWTIHNVQFTQAKEEFVTSV 107
XP_004990081   4 STrVLAPHPVSNLRRIERV--PRADETRA--------------EKRLRLQLDADHEFHQRFWHKNNTDFKQAREAFLEEH 67 
XP_007395938  26 RDlVGPPDPVSNLRPVIYDd-TPAQSAPAshpyslkeftgdtrEYQWKVQRQELDAYNHNFWADSNTRFNAALEARLSSL 104
KJE94572      45 IVrMGPPDHVTNLRPFEII--PAANESVA--------------EREYREMRIAAAQGHDRFWRSNNTRFVQEKAAFEAEL 108
XP_788825     60 RDwIGPADKKSNLRRVILA--QPQNETDV--------------ERDYRVSRTATNDWNHQFWSKQNEIFIKAKEEFVQAR 123
A8WJ42        17 FDwVGPPDSVSKIRKIMLR--RVDNESEL--------------ERQYRAAREELNQWNSDFWAEHNQLFDRQKSEFVEKK 80  Caenorhabditis ...
XP_002596441   7 HDwIGPADPSSNLRPIKFR--VPTGESAA--------------EERLRQLRADTQKWNQEFWSNHNQQFNKEKADFIRSW 70 
EPS98567     100 PESCPVEDR---------ES--------ALSAFYRRWADQEAERQRAYSAEWRRRNWASISLGARLAYEKVA 154
ESO02537      65 -------N-----------GkdknlttaEMGIFYKKFLDDNYRIHLQYNKSWYLKNFKILWLTVLVQFEKIF 118
EEC13752      72 LEEYSRQG-----------IkkenvpaeEMAEFYRTFLNDNHQKHMQYNWTWYKKNFGLLWPAIKSNWAYYS 132
EFX71456     108 LERRG--KDa--------STtgqpltadDLSEFYRAFLDQNREKHLKYNVEWHMKNMGLLWPGIKANLSRFK 169
XP_004990081  68 REDMSagrl----------------pahLMAEFYCSFLEAHREDHITYNLEWWGRAARQIPLYVHAYVSRFF 123
XP_007395938 105 PADSTSYDR---------EL--------AMSDFYGSWLAQEQDRLRAYNAEWRKRNWDNIVLEARVKYQKFM 159
KJE94572     109 ARTQPgqpi----------------taeTLSVFYKRFLDHNLPLHKAYNAEWWRINISMLVPAARATIARVR 164
XP_788825    124 LGEKQKETEdssdndvigSGvkqvlsaeDMAEFYQQFLKDNQHSFHDYNKQWYRKNFSLLWPAVKANVSMFM 195
A8WJ42        81 QKELGrleh---------------vsanELSEFYRDFLNDRHVAMMVYNKEWYRRNLQLIWPALKVNVVRFF 137 Caenorhabditis briggsae
XP_002596441  71 LEKEDFKSVh-------tDGdkrmppaeDMSEFYRTFLTEHQHGQLQYQREWYKRNLYIIYLSFRVKMFQLV 135
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