7LS6


Conserved Protein Domain Family
UMP1

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pfam05348: UMP1 
Proteasome maturation factor UMP1
UMP1 is a short-lived chaperone present in the precursor form of the 20S proteasome and absent in the mature complex. UMP1 is required for the correct assembly and enzymatic activation of the proteasome. UMP1 seems to be degraded by the proteasome upon its formation
Statistics
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PSSM-Id: 461627
Aligned: 66 rows
Threshold Bit Score: 114.237
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7LS6_H        27 PslPDTLRQqegGA---VPLSTQLNDRHPLESTLK-NWETTQRQRQMEQYRQIFGIAEPMKRTMEMEIVNR-------T- 94 
EFN58357      15 TapHDALRQ---GL---VTLKDGAAASHPVEQIQKlSGP-AGEKARLEMLSNVYGTALPARMQIERQILDRqgggswgLm 87 
XP_002959191  11 SkaHDALRL---GL---VSLKEDATVRHPVEVIQS-EHRQRTLASQHQMLRDLYGIAAPARAQIEAQILSK-------F- 75 
XP_001846424  18 FagHVEPRD--------ENCAAQLRFGHPLKQSEL-NYDQHRQNLNLQMLRNREGLAAPLKLTMELKSVSK-------V- 80 
Q9VIJ5        14 SvlNATGRV---GMpteANCLNQLAHVHRLRDSEL-NYNEHQYNRNMQMLRNHEGLGVPLKMGMERFAARQ-------V- 81  fruit fly
XP_001989246  14 HvlNASGRA---ALpteQNCLSQLAHVHRLRDSEL-NYNDHRYNIDMQMLRNREGLGAPLKMGMDRFAARQ-------I- 81 
1_pfamImport   4 YgvTSSLRT---GL---GNVRSSLKHSHQLEISEK-NYESNLRETEYNMLRNSQGIHAPLRKRMELTAVQK-------At 69 
XP_006012796  26 YgvQDTLRK---GF---SSVKNELLPCHPLELSEK-NFQLTHDKMNFTTLRNIQGLHAPLKLQMEYKAVKQ-------I- 90 
Q9CQT5        25 FesHDLLRK---GF---SCVKNELLPSHPLELSEK-NFQLNQDKMNFSTLRNIQGLFAPLKLQMEFKAVQQ-------V- 89  house mouse
XP_417119     25 FegHGLLRR---GF---ACVKNELVPSHPLELSEK-NFQLNQDKTNFAMLRNIQGLHAPLKLQMELRAVKQ-------A- 89 
7LS6_H        95 DFNPLS-TNg-sIHRDILLNKECSIDWEDVYPgtglqaSTMVGD-DVHSKIEKQL 146
EFN58357      88 ERLPG--LPsskLGLESMTGALEDFGFESYLNlp---aDSEVAPpDLHSQMEQRL 137
XP_002959191  76 TRLPGAgTSs-lLGLESLTGELDEFKYESYLAlp---eVSTLPPvDLHSQMELKC 126
XP_001846424  81 GHLPF--LPstnVARDVLTGRDELIDYTDIFNla---eNSEIMA-QPHAVMEKNL 129
Q9VIJ5        82 GRLPF--LSssnFMDDVLTGRCDSIGFEDFMNlp---eNSEHMR-QPHAVVEKSL 130 fruit fly
XP_001989246  82 GRLPF--LQssnIMDDVLTGRCDEISFEDFLNlp---eYNENLR-QPHAVVEKSM 130
1_pfamImport  70 TRLPS--LPssnFAMDILNGNDTCISIEDNFcr----gDTEVMG-DPHLMMEHKL 117
XP_006012796  91 QRLPF--LPssnIALDILRGNDECIGFEDILNdp---tECEVMG-EPHIMVEYKL 139
Q9CQT5        90 HRLPF--LPssnLSLDILRGNDETIGFEDILNdp---sQSELMG-EPHVMVEHKL 138 house mouse
XP_417119     90 QRLPF--LHssnMALDTLRGNDECIGFEDILNdp---sQSEVMG-EPHMMMEYKL 138
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