Conserved Protein Domain Family
dut
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TIGR00576: dut 
deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)
The main function of these proteins is in maintaining the levels of dUTP in the cell to prevent dUTP incorporation into DNA during DNA replication. Pol proteins in viruses are very similar to this protein family. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). Changed role from 132 to 123. RTD [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Links
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Statistics
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PSSM-Id: 273149
Aligned: 23 rows
Threshold Bit Score: 176.271
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O07199     4 TLAIVRLDPGLPLPSRAHDGDAGVDLYSAEDV-------ELAPGRRALVRTGVAVAVPF-GMVGLVHPRSGLATRVGLSI 75  Mycobacterium tuber...
P06968     7 KILDPRVGKEFPLPTYATSGSAGLDLRACLNDa-----vELAPGDTTLVPTGLAIHIADpSLAAMMLPRSGLGHKHGIVL 81  Escherichia coli K-12
Q45920     8 KILDKRLGSEFPLPAYATTGSAGLDLRACLDEp-----lKIEPDETCLISTGLAIYLGHsNVAATILPRSGLGHKHGIVL 82  Coxiella burnetii R...
CAA16477   7 EVLIRRVDPDVPLPAYAQPGDAGADLRTTVER-------ELAPGERAVLPTGVSVALPE-GYAAFVHPRSGLAARCGVAL 78  Streptomyces coelic...
O66592     7 KIKRLPHAQDLPLPSYATPHSSGLDLRAAIEKp-----lKIKPFERVLIPTGLILEIPE-GYEGQVRPRSGLAWKKGLTV 80  Aquifex aeolicus VF5
AAB97415   8 ELQRLPHAEGLPLPAYQTAEAAGLDLMAAVPEda---plTLASGRYALVPTGLAIVLPP-GHEAQVRPRSGLAAKHGVTV 83  Bradyrhizobium japo...
O83855     2 IRVRAVVYPGASFPEYQTLGSSGADLRAFLPGgp----lEVHPLGRVLVPTGVCVELPV-GLEMQIRPRSGLALEYGVTV 76  Treponema pallidum ...
AAC14879   3 KVKIVRLNQKAILPVYATAHAAGMDVSACLDAp-----vTVPSSASALIPTGFAIELPE-GYEAHVRPRSGLALRHCISL 76  Chlorobaculum tepidum
O25536     2 KIKIQKIHPNALIPKYQTDGSSGFDLHAVEEV-------MIKPHSVGLVKIGICLSLEV-GYELQVRTRSGLALNHQVMV 73  Helicobacter pylori...
CAA04589   1 -MIKIKLTHPDCMPKIGSEDAAGMDLRAFFGTnpaadlrAIAPGKSLMIDTGVAVEIPR-GWFGLVVPRSSLGKRHL-MI 77  Bacteriophage T5

O07199    76 VNSPGTIDAGYRGEIKVALINLDpAAPIVVHRGDR--IAQLLVQRVELvelveVSSFDEAGLASTSRGDGGHGSSGG 150 Mycobacterium tubercul...
P06968    82 GNLVGLIDSDYQGQLMISVWNRG-QDSFTIQPGER--IAQMIFVPVVQ-----AEFNLVEDFDATDRGEGGFGHSGR 150 Escherichia coli K-12
Q45920    83 GNLVGLIDSDYQGPLMVSCWNRG-KEPYTINPGDR--IAQLVVLPILK-----AQFAVVEEFELTERGAGGFGSSGQ 151 Coxiella burnetii RSA 493
CAA16477  79 VNAPGTIDAGYRGEIKVIVVNLDpRESVRFERFDR--IAQLVVQQVERvrfrqV----AE-LPGSARAEGGFGSTGG 148 Streptomyces coelicolo...
O66592    81 LNAPGTIDADYRGEVKVILVNLGn-EEVVIERGER--IAQLVIAPVQRvevveV-----EEVSQTQRGEGGFGSTGT 149 Aquifex aeolicus VF5
AAB97415  84 LNSPGTIDADYRGEIKVILINHG--AAVLRDQARRadRAKMVIAPVVQaalvpV-----ATLSATDRGAGGFGSTGR 153 Bradyrhizobium japonicum
O83855    77 LNSPGTIDADYRGEIRVLLVNLG-LAAFVVSHGDR--IAQAVISSVLRveyvrS-----GSISLTERGKGGYGSTGV 145 Treponema pallidum sub...
AAC14879  77 PNSPATIDADYRGEVGVILINHG-REPFTVSHGDR--IAQMVVAKVDHvvfeeV-----ESLSETARGEGGFGHTGV 145 Chlorobaculum tepidum
O25536    74 LNSPGTVDNDYRGEIKVILANLS-DKDFKVQVGDR--IAQGVVQKTYKaefieC-----EQLDETSRGSGGFGSTGV 142 Helicobacter pylori 26695
CAA04589  78 ANTAGVIDSDYRGTIKMNLYNYG-SEMQTLENFER--LCQLVVLPHYSt----HNFKIVDELEETIRGEGGFGSSGS 147 Bacteriophage T5
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