Conserved Protein Domain Family
PHD_SPP1
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cd16039: PHD_SPP1 
PHD finger found in Set1 complex component SPP1
Set1C component SPP1, also called COMPASS component Spp1, or Complex proteins associated with set1 protein Spp1, or Suppressor of PRP protein 1, is a component of the COMPASS complex that links histone methylation to initiation of meiotic recombination. It induces double-strand break (DSB) formation by tethering to recombinationally cold regions. SPP1 interacts with H3K4me3 and Mer2, a protein required for DSB formation, to promote recruitment of potential meiotic DSB sites to the chromosomal axis. SPP1 contains a PHD finger, a zinc binding motif.
Links
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Statistics
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PSSM-Id: 277186
Aligned: 6 rows
Threshold Bit Score: 80.5983
Created: 26-Mar-2015
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding siteputative
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C [CH] H [CH] C [CH]Click to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         # #             #  #    #  #               #  #
O74508       120 YCICQKPDdg--sWMLGCDGCEDWFHGTCVNIPESYndltvQYFCPKC 165 Schizosaccharomyces pombe 972h-
XP_006454375 353 YCVCKTKYde-drFMIACDRCDEWYHTTCVNMPDLEvelvdQFFCPPC 399 Agaricus bisporus var. bisporus H97
Q03012        24 YCICKRPDyg--eLMVGCDGCDDWFHFTCLHIPEQFkdlvfSFYCPYC 69  Saccharomyces cerevisiae S288c
EMR10514     142 YCICQKPDtg--cWMIACDGCDNWYHGECVKILEADeelldKYFCDFC 187 Pneumocystis murina B123
AFW69662     173 YCICCKPDdn--rAMIACDQCDEWYHFDCINLLGPPp---eSFFCPAC 215 Zea mays
CCF54193     218 YCVCQKRQddvegGMIMCDRCEQWYHYRCMSMNEADvelvdRFICPPC 265 Ustilago hordei

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