Conserved Protein Domain Family
RTA1

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pfam04479: RTA1 
RTA1 like protein
This family is comprised of fungal proteins with multiple transmembrane regions. RTA1 is involved in resistance to 7-aminocholesterol, while RTM1 confers resistance to an an unknown toxic chemical in molasses. These proteins may bind to the toxic substance, and thus prevent toxicity. They are not thought to be involved in the efflux of xenobiotics.
Statistics
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PSSM-Id: 461325
Aligned: 250 rows
Threshold Bit Score: 137.211
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCE79109     146 FTCGYGLEFGGFAARVASFGDmtaSDPFIAQLVMLTIAPAFIMGGIYFLFAQLVVIH----GRNYSLLRPLWYSYIFITC 221
EAQ70743     110 LIMGGIWESAAFTVHAIGAKDqqsEPLAVGYSMLYLLAPLWITAFVYMTFARQVWYWt--pDQRLFMLSAHVLSKVFVLA 187
EPE28658      63 iVASGMAQTLAYVLRILSILNpasFGFYAGWFVLILVAPLFTNAFVYMVMGRMIWNYv--pEKKIHRVTAWRFGMYFVVL 140
EMR84474      53 IIVSGIAQTLAYIFRVISIKNpasFGNYAAWFILILIAPLFTNAFAYMVMGRMIWNYv--iEAKIWKITAWRFGLYFVIL 130
EHK48506      52 IIMSALWQTLTYIFRTISIQNpasYGNYAAWFVLILVAPLWTNAYAYTLFGRMVWAYt--aTHKLWRIKAWQFGFIFILL 129
EPE04416      52 IIMSSLWQFLTYIFRALSIQTpasFGNYAAWFVLILIAPLWTNAYSYMVFGRLVWNYt--pDRKVWGLRAQRFGVIFVML 129
ERS95305      58 IVMSVLWQLLTYIFRTISIQTpasFGDYAAWFVLVLIAPLWTNAFAYMVFGRLVYNYt--pDRKLWGVPASRFGLLFVVL 135
EGU85649      78 AIMGATWETIGFAFKTLGSRNqqnMTYLIWGQLFFLLAPLWINAFVYMAVARMVYFRm--pDRKLLGIKAIRMTLLFVWL 155
Q2GRV8        74 LVMGALWEYACFMLRTLGAFDqqnGGLVVGGTVLFLLAPLWINAFVYMVVARLIHFLlpsnSQRILGLSPRWLAKAFVAV 153 Chaetomium glob...
XP_003044402  78 IVMGALWECVCFILRALGARDqqeSTYMIVSTLLLLLAPLWINAFAYMTVARLVHFLh--pRRRLAGLSAQWLAKCFVAV 155
CCE79109     222 DVLSLIIQAGGGGSASVASQNYe-dTDPGTYTMIAGIAFQVFAMSIFLIFWFDFLRRMY--------FHdlpmsekalle 292
EAQ70743     188 DVLAFVLQFLGAALVTNHKAKTpeeIRRGAILHLAGLSLQLTVTAIFLVLMAAWHLKMIayeaerahldpy--------- 258
EPE28658     141 DVCALVIQIIGAVQATGENTTTk-qVLRGLHMYMGGVGVQLGFILLFLFFAVKFHRIVRqqnstsfgSPgl--------- 210
EMR84474     131 DVAALLIQIYGAATAASDNASAd-eTLQGLHVYMVGVGIQQFFIFVFLFFAFKFHQTLRsqsrqnvyTSrq--------- 200
EHK48506     130 DIVAFVVQVVGAVQATGSNTTDq-qVLNGLHIYMGGVGLQLVFILIFCIYALRFYLETRqspdarqaQ------------ 196
EPE04416     130 DIVAFIVQVYGAAAASAKDAATd-dVLRSLHIYMAGVGIQLFFLLICFVFGIRLWLMMRtdai-myphLrp--------- 198
ERS95305     136 DIIAFVIQVYGAATASANGIPEd-eVLRDLHVYMGGVGVQLLFILICSVFGIKLWTVMRreakqsprALrp--------- 205
EGU85649     156 DIILFLVQGAGGSMLSNNDDMNv--IRIGQKLYMAGVGLQLAVIVIFIGITAFFYFKLRqlegr---------------- 217
Q2GRV8       154 DVLSFFIQAAGGGMLAGQDGGDt--VQTGQRIYMAGIGVQLAFVVIFAAITGLFTLRLErlmgagll------------- 218 Chaetomium glob...
XP_003044402 156 DVLCFIIQAAGGAMLADQNNSDt--ADLGRKVYMAGVGVQLGCVLVFLAIHTLFRREISrnartgk-------------- 219
CCE79109     293 vsdehgniprcvamynkktvlnyiklllnvpsarefktlyleknynpgfaelrerrlFHWFPLFLTLGVIFIYIRCVYRV 372
EAQ70743     259 ---------------------------------------------gdcspegpirrsWKFLHAAMYIAVLLIAIRLCFRL 293
EPE28658     211 -------------------------------------------------------thALILLYNLYTVLGFIILRIIFRL 235
EMR84474     201 ---------------------------------------------------------awSLLYVLYAVILLITIRIIFRL 223
EHK48506     197 -----------------------------------------------------------VLFYAQILALAMIVLRIIFRI 217
EPE04416     199 ---------------------------------------------------------alMLLYVQFVVLVLIIVRIVFRI 221
ERS95305     206 ---------------------------------------------------------alLLLYVQFAVLALIIIRIIFRI 228
EGU85649     218 -----------------------------------------------------smgrMKWLILTMLAVLILIVIRIVYRL 244
Q2GRV8       219 -------------------------------------------------eprhnltvTRHLVWFMLTVIGLIVVRIVFRF 249 Chaetomium glob...
XP_003044402 220 --------------------------------------------------lrtrslwTMSLLWVIYVVLALIVVRIIFRL 249
CCE79109     373 VELSM---GF--NGYLITHEVYLMTLDALMIALNGIIFCFFHPTFVFGV 416
EAQ70743     294 AESGQivvGSt-RGGLASSQILQYLLDAAPVMLCLAVLAVAHPGRFLIG 341
EPE28658     236 IEYAQ---GL--DSGIPNKEGYQYGLDSLPMLIALVLLDAFHPGRIMKG 279
EMR84474     224 VEYSQ---GL--KSSIPNHEAFQYSLDSVPMLFALVFLNIFHPGRIMAD 267
EHK48506     218 CEYSQ---GL--DSKIPNHEAYQYCLDSLPMFIALVVYNVVHPGRIMRG 261
EPE04416     222 VEYSS---GL--KSSIPLHEAYQYSLDTLPMFLALLMYNIVHPGRIMQG 265
ERS95305     229 VEYAS---GL--KSSIPNHEAFQYALDTLPMFVAIVLYNIVHPGSIMRG 272
EGU85649     245 IEFGP---GVneHNQLLIHEEYPLGLDATPILIALVLLNIMHPGFVLRG 290
Q2GRV8       250 VEFSG---GVssSNPILANEAYQLGLDALPMLIALLLINAVHPSKVLKG 295 Chaetomium globosum CBS 148.51
XP_003044402 250 VEFSQ---GVssSNVILRHEEFQLYLDALPMLIAVVVLNVVHPGMVLQG 295
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