Conserved Protein Domain Family
beta-trefoil_FGF16
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cd23326: beta-trefoil_FGF16 
FGF domain, beta-trefoil fold, found in fibroblast growth factor 16 (FGF16) and similar proteins
FGF16 plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. It is required for normal cardiomyocyte proliferation and heart development. FGF16 interacts with fibroblast growth factor receptors, FGFR1 and FGFR2. FGF16 contains a FGF domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.
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Statistics
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PSSM-Id: 467012
Aligned: 5 rows
Threshold Bit Score: 307.67
Created: 6-Apr-2021
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O43320        55 HLKGILRRRQLYCRtGFHLEIFPNGTVHGTRHDHSRFGILEFISLAVGLISIRGVDSGLYLGMNERGELYGSKKLTrECV 134 human
XP_014346421  40 HLKGILRRRQLYCRtGFHLEIFPNGTVQGTRQDNSRFGILEFISLAVGLVSIRGVDSGLYLGMNERGELYGSKKLTrECV 119 coelacanth
Q2HXK8        51 HLKGILRRRQLYCRtGFQLEIFPNGTVHGTRQDHSRFGILEFISLAVGLVSIRGVDAGLYLGMNEKGELYGSKKLTaECV 130 zebrafish
XP_018088425  50 HLKGILRRRQLYCKtGFHLEIFPNGTVHGTRQDHSRYGILEFISLAVGLVSIRGVDSGLYLGMNERGELYGSKKLNrECV 129 African clawed ...
NP_001038115  55 HLKGILRRRQLYCRtGFHLEIFPNGTVHGTRQDHSRFGILEFISLAVGLVSIRGVDSGLYLGMNERGELYGSKKLTrECV 134 chicken

O43320       135 FREQFEENWYNTYASTLYKHsDSERQYYVALNKDGSPREGYRTKrhQKFTHFLPRPVdpsKLPSMSRDLF 204 human
XP_014346421 120 FREQFEENWYNTYASTLYKHsDTGRPYYVALNKDGSPREGYRTKrhQKFTHFLPRPVdpdKIPAMYRDLF 189 coelacanth
Q2HXK8       131 FREQFEENWYNTYASTLFKHaDTGRYYYVALNKDGSPREGSRTKkhQKLTHFLPRPVeieKIPQAYRELF 200 zebrafish
XP_018088425 130 FREQFEENWYNTYASTLYKHaDSDRQLYVALNKDGSPRDGYRTKryQKFTNFLPRPVdplKLPVMYRDLY 199 African clawed frog
NP_001038115 135 FREQFEENWYNTYASTLYKHpDSERHYYVALNKDGSPREGYRTKrhQKFTHFLPRPVdpaKIPAVYRDLF 204 chicken
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