2M9U


Conserved Protein Domain Family
MLVIN_C
?
pfam18697: MLVIN_C 
Click on image for an interactive view with Cn3D
Murine leukemia virus (MLV) integrase (IN) C-terminal domain
This is the C-terminal domain (CTD) which can be found in murine leukemia virus (MLV) integrase (IN) proteins. The MLV IN C-terminal domain interacts with the bromo and extraterminal (BET) proteins through the ET domain. This interaction provides a structural basis for global in vivo integration-site preferences andt disruption of this interaction through truncation mutations affects the global targeting profile of MLV. The CTD consists an SH3 fold followed by a long unstructured tail.
Links
?
Statistics
?
PSSM-Id: 436671
Aligned: 6 rows
Threshold Bit Score: 125.716
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
2M9U_A         6 HSHMVGDTVWVRRHQTKNLEPRWKGPYTVLLTTPTALKVDGIAAWIHAAHVKAADPGG--GPSSRLTWRVQRS-QNPLKI 82  Moloney murine ...
EHB15683     165 HRYRSGDWVFVRQHQQKDLEPHWKGRYVTVLTMPTTLKVDGIASWVHYTHVRPVDPHAi-LEDFITSWQVAKDrDNPLKL 243
1_pfamImport   2 HRYWPGDWVYVHHHRQETLEPRWKRPFLVILATPTALKVDSISAWVHYTHTRPADLFAl-REEFLPQWKAEIDkTNPLKL 80 
EHB15633     164 HRYQPGDWIFVRRHRQKDLEPRWKGPYVTVLTTPTALKVNGIASWVHCTHVRLADPHAv-LEDYIPSWQVSKNrDNPLKL 242
EHB17156     154 HCYRPGDWVFVQRYRQKNLEPHWKGPYVIVLTTPNALKVDGIASCIHYTHARPADPHTv-LKDFIPLWQVSKDrDNPLKL 232
EGV97740      48 HPFQIGDSVYIRRHQSKTLEPRWKGPYTVLLTTPTALKVDGIAAWVHASHAKKANTSEnwVTNETPKWKLQRT-QNPLKI 126

2M9U_A        83 RLTR 86  Moloney murine leukemia virus isolate Shinnick
EHB15683     244 KLRR 247
1_pfamImport  81 KLRR 84 
EHB15633     243 RLCR 246
EHB17156     233 KLHR 236
EGV97740     127 RLLR 130
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap