7EMF,5U0P


Conserved Protein Domain Family
Med27

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pfam11571: Med27 
Mediator complex subunit 27
Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. The ubiquitous expression of Med27 mRNA suggests a universal requirement for Med27 in transcriptional initiation. Loss of Crsp34/Med27 decreases amacrine cell number, but increases the number of rod photoreceptor cells.
Statistics
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PSSM-Id: 463298
Aligned: 43 rows
Threshold Bit Score: 77.7148
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7EMF_0       228 LDIWSKSNYQVFQKVTDHATTALLHYQLp-QMPDVVVRSFMTWLRSYIKLFQAPCQRCGKFLQ--DG----LPPTWRDFR 300
Q10477       173 FIFFHDTRGKFSVYCSSSKDDAITFSINrnNNFLGNLWSLMPKILDYQHLYSKPCDFCKSLI---SPvyleLPSVRRNAN 249 Schizosaccharom...
XP_002482680 279 pPEWRVSSRNSFGR-PSRLENAILHQLNs-RPRKWDLCYLLEYVLSYSNIRSQPCKKCNHVTGslAQ----LPIVRKPVA 352
CAK46449     244 VPDWRVFTRTPGGQTPSKVETAVAQCLNs-RPRQWDLLYLLDMISSYSTIKQTPCAKCTKMTDstAT----LPTIRKPSS 318
GAD96507     241 gmGWRVSNKQSPGKPKTKLETSVSMSLNq-RPRKWDLAYLLEMISSYSEIKKTPCVKCNKMIDntTL----LPTIRRSKT 315
CBF79081     257 VPEFNVSSKSPSGEPSSRVETAVLACLNa-RPRKWDLKFLFGMISSYSNIFQTTCTRCGKMQDqaAN----LPTLRRPKT 331
Q4W9T3       242 MVDWRVQELAAPGRPKTKLETAVAACLNa-RPRQWDLAYLLDMIASYSDVKQTPCVKCGKMTDnaAQ----LPSVRRPNP 316 Aspergillus fum...
Q2U0Q4       275 VPEWQVSSRTMPGQVKTKLESAVSDCLNs-RSRQWDLAYLLDMISSYSDVKQTPCVKCGRMTDnaAQ----LPAVRQQKQ 349 Aspergillus oryzae
EAW13416     241 VSDWRVMDKAVPGKPKTKLELGIMACLNa-RPRQWDLAHLLDMISAYSAVKQTPCAKCGKMTNsaAQ----LPTIRQPKP 315
EPS30709     230 IVEWNVSKQPLPGRAPTKIEDSIVQCVNa-RPRKWDLAFVIDMISSYSDMKQTVCVKCNKLTDssAQ----LPVIRRAQA 304
7EMF_0       301 ------------------------TLEAFHDTC 309
Q10477       250 stvk----------------ptskDILALHAEC 266 Schizosaccharomyces pombe 972h-
XP_002482680 353 ltsagdgsapaegsgngasnelgvVWEAYHQAC 385
CAK46449     319 tpqe----------------qgsqTWEAYHQGC 335
GAD96507     316 vespd--------------gkkstTWEAYHQNC 334
CBF79081     332 kepqt---------------dqppTFEAYHATC 349
Q4W9T3       317 lqssq---------------gqpvLWEAYHPTC 334 Aspergillus fumigatus
Q2U0Q4       350 qsdp----------------qqppIWEAYHSSC 366 Aspergillus oryzae
EAW13416     316 tsdgq---------------esslQWDAYHTDC 333
EPS30709     305 ipsaqq-------------epqglVFDALHASC 324
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