2MVW,2D8V,2JUN,2VHF


Conserved Protein Domain Family
Bbox1
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cd19757: Bbox1 
B-box-type 1 zinc finger (Bbox1)
The B-box-type zinc finger is a short zinc binding domain of around 40 amino acid residues in length. It has been found in transcription factors, ribonucleoproteins and proto-oncoproteins, such as in TRIM (tripartite motif) proteins that consist of an N-terminal RING finger (originally called an A-box), followed by 1-2 B-box domains and a coiled-coil domain (also called RBCC for Ring, B-box, Coiled-Coil). The B-box-type zinc finger often presents in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain, in functionally unrelated proteins, most likely mediating protein-protein interactions. Based on different consensus sequences and the spacing of the 7-8 zinc-binding residues, the B-box-type zinc fingers can be divided into two groups, type 1 (Bbox1: C6H2) and type 2 (Bbox2: CHC3H2). This family corresponds to the type 1 B-box (Bbox1).
Links
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Statistics
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PSSM-Id: 380815
Aligned: 380 rows
Threshold Bit Score: 27.0751
Created: 4-Sep-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C [DC] C [CH] [CH] HClick to see conserved feature residue pattern help
Evidence:
  • Structure:2JUN; Homo sapiens Midline-1 binds two Zn2+ ions through its B-box motif.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #           #  #    #  #     #        #     
2MVW_A         11 VCTrCKes----adFWCFeCEQlLCAKCFEa--HQwf---lkHEARPL 49   human
2JUN_A          5 LCQfCDqdpaqdavKTCVtCEVsYCDECLKa-tHPnkkpftgHRLIEP 51   human
XP_011402947  103 YCQtCTege--iacNHCTdCKAyLCEFCSKy--HTrsveykgHTLIPQ 146  Amphimedon queenslandica
XP_012941716  529 FCTsCSren--eavICCTtCPAyLCHDCQTg--HGtmrlfssHKLDPI 572  California sea hare
XP_013069102  446 GCTgCTrdq--eavTCCTtCMAfLCAECKEg--HKtihhfqgHSLTPI 489  Biomphalaria glabrata
XP_019857065  269 RCAeCErnl---avKYCSeCSAsYCEACNKq-qHTgskvrarHKPIPI 312  Amphimedon queenslandica
RHY66376     1954 LCQhCEdvq---atVYCNlCPQaLCDECSRh-iHEnth-faqHVDTIT 1996 Aphanomyces astaci
RHZ28423       51 MCCkCVdr----atHSCVeCDLlYCLVCSDq-rHSkgs-fqrHTVTTI 92   Aphanomyces astaci
EPB78646      291 LCDeCLeaa---atHFCRvCMQyYCEACSIrmdHSvg----sHLDSPT 331  Ancylostoma ceylanicum
KFG46580      222 LCAqCEana---atVFCRgCVAnYCDACSLs-lHErhprladHKFRLL 265  Toxoplasma gondii p89

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