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Semaphorin 4F C-terminal Semaphorins are a large and diverse family of proteins, widely expressed across divergent animal phyla. They are secreted and membrane-associated proteins, conserved both structurally and functionally, and they are divided in eight classes (1-7 and V). They are involved in axon guidance and influence the migration of neurons and glial cells. This entry represents the C-terminal domain of Semaphorin 4F (also known as Semaphorin-W) which plays a role in visual system development and in oligodendrocyte precursor migration and differentiation. Like other Semaphorin 4 members, it includes a Ig-like domain, adjacent the PSI domain (plexin-semaphorin-integrin domain, conserved across all semaphorins), a transmembrane region and a short intracellular tail. The latter is rich in proline residues similar to other transmembrane semaphorins suggesting that it may interact with cytoskeletal or signalling proteins. It also contains a cyclic nucleotide-dependent protein kinase phosphorylation site, involved in signal transduction into the cell. Sema4F is found in glutamatergic synapses, preferentially in postsynaptic dendrites, attached to SAP90/PSD-95-scaffolding protein. Sema4F interacts with SAP90/PSD-95 PDZ domains through the critical last last three C-terminal amino acids. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",