Conserved Protein Domain Family
Hyccin

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pfam09790: Hyccin 
Hyccin
Members of this family of proteins may have a role in the beta-catenin-Tcf/Lef signaling pathway, as well as in the process of myelination of the central and peripheral nervous system. Defects in Hyccin are the cause of hypomyelination with congenital cataracts [MIM:610532]. This disorder is characterized by congenital cataracts, progressive neurologic impairment, and diffuse myelin deficiency. Affected individuals experience progressive pyramidal and cerebellar dysfunction, muscle weakness and wasting prevailing in the lower limbs.
Statistics
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PSSM-Id: 462903
Aligned: 24 rows
Threshold Bit Score: 176.062
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_009014294  58 TCYESYGESVRNDKELMDELYCLLnhtsfhkydQLLDPVCHQLFN-FYRSSVhsLHCFAIEFIPTIVGSYL--SASMSSS 134
4_pfamImport   1 KFLNKVAPSSLFAANYISTNYTDV---------DLIQPIIGQILAiYYKSGV--LRLYALQFVPGFVSLYL--LALSKKQ 67 
XP_001897193  34 IQLTRETCKTQYLINYLSCNYTDV---------DLVQPVVAQLLAcYYRGGI--LRYFVLQCIPSLIHIYL--LALAKRQ 100
XP_016660375  19 DDWATFAITTSQNKTLIESIYAVLddih--kysKLVDRICGALFN-CYRTEEtdLHLFVLLFIPHLTYSYL--NSIAHVD 93 
Q9FMI8        92 ADSDRPALSLLSSRAAYSLISNSLcnp---asgSGSDPLCQWLYE-TYLSSDppLRLVVLSFFPLLVGMYL--SRIHSSD 165 thale cress
XP_009112116  69 ADSDRPALSLLSSRPAYSLISASLrdp---ssgSGSDPLCQWLYE-TYLSSDqpLRLVVLSFLPLLAGTYL--SRIHSSD 142
XP_004966258  60 ADSDRPARALLRSPAAYSALSDALra-----ggGADDPACHWLYD-TLLSADpdLRLAALAFLPLLAALYL--RRLPPEL 131
5_pfamImport   1 TSLAAYAKLAHEKDAVLVSFKSAVnsfqneslvELVQPASHQLFE-FYRSGNndLKIHAISFFPALVGGYL--LACSSKH 77 
XP_009014774  16 EKLLDFAEDIKKDHTLKKEIFFFIenk---nksEELDPVVHQLFN-FYRLDNdqLKKFSLEFIPAMLLKYY---SAINGQ 88 
XP_015788203  23 DEIHAYAIGVFNYPDLINAILNALeddk--qyeKFLAPICTQLFN-YHRLKDdrLRLFVIAFLPSLIGVHLlySVKPLEV 99 
XP_009014294 135 HLH---SG---CLAAFLLGVYNL-----------GNSEMTTINafpiVPSLS-----QPSVYHD-PSSVSl--ITRLTEA 189
4_pfamImport  68 QKS---VS---LFETFLTAIYNEeivkd-sergtNEKKTEDIR----IPSIR-----HHSVYHD-PAKIQiqtELPITRN 130
XP_001897193 101 KKS---VS---IFETFFLAMFNEeilaggilsesVTKKVEEVR----IPSIR-----FPSVYHD-PKKLSlasDIALKSG 164
XP_016660375  94 KQS---CR---SIEALLIGIYNLeav-----denNTPRFISFR----LPSLA-----QPSIYHE-PSSLA---PTSLTET 149
Q9FMI8       166 STSlpsLS---GFEAVLLAIYAAevk-----araGKPILVH------IPDLS-----QPSLYHT-PRN-GvdkSRD-SNP 223 thale cress
XP_009112116 143 SSSlpsLS---GFEAVLLAIYAAevk-----sraGKGVLVH------IPDLS-----QPSLYHT-PRNGGvdrSRDSSNH 202
XP_004966258 132 PSS---LS---GFEAVLLAVYSSeak-----nrqGKPVLVQ------VPDLS-----VPSLYHT-PASSPsskSPRRPQP 188
5_pfamImport  78 ENA---SKikvSLGTCLLAIYNLvcee---nekeNSDQNYEIE----MPNLS-----NPSIYHD-PM------AYPFSEY 135
XP_009014774  89 QVV---IS---SLEAFLLGMYNLd---------sTRLKLNCQTdfllQPNSAlifntTSSIYHDiPMGVT---TSMLTRS 150
XP_015788203 100 RRK---YR---CVDTVLLGIYNVeit-----nedGLGSNRTFR----IPTTS-----KPSIYHE-PPTTS---ASTFSQP 155
XP_009014294 190 ALSVRln--sEHVPVKRPTH-KKY---------DGITPQNRSAILSFVISVYNMNITLMSFR--SRKSLCHLSS-KL--- 251
4_pfamImport 131 ASVTP-----VLHTVHFGPF-PSV---------SKMNGENRFTVLNRILFSVNESLFEVASEi-AARYVCLGTL-SV--- 190
XP_001897193 165 APAFVq----ATKTVRIGPY-KSV---------DRIFPQNRQTVLTRLLKSVNGCLCRLSRDv-ICQGICLSTI-AL--- 225
XP_016660375 150 AIRRLeq--rDTHPVRRGPF-NQI---------ERLSASNRMEVLSNLYFIYYKNLNLLPEVynPFDRFYRVTS-KM--- 213
Q9FMI8       224 t---------ASVGVLSPQLePQI----------AVKSTKRASIVGVGLQCYFKEISQMPAW--SKLEFCKFSAswa--- 279 thale cress
XP_009112116 203 v---------ASVGVLSPQLePQV----------AVKSTKRAGIVGVGMQCYFKEISQMPAW--SKLELCSFAGawa--- 258
XP_004966258 189 PPIPPpq-atPVVGVLSPPLePQA----------AVKSTKRAGIIGVAFEAYYSKISQMPAA--SKVDACNAVAawa--- 252
5_pfamImport 136 TVNSSnh--gRT-FVKLPPM-KSY---------LNIYPENRSEIMDVIMSCYADYVAIIPTT--SLIQVCDMCL-QI--- 196
XP_009014774 151 ALDRWhvhnsHQSKIKNVTYlKAT---------DSVTNKNKLTIMIHALQRYNEHISDFSDL--SHLTLCKFCM------ 213
XP_015788203 156 TSTSNdn--sTKADSSSLPY-INVpvygnykssDYINASNRVSVLTALLHLFHDQMSSLPKQ--SHAALCRMTVsVLeke 230
XP_009014294 252 -------------------------SRTGFEDYveclspianqhCSTSGDNGSWQKDPESMHQ----------------- 289
4_pfamImport 191 -------------------------CRSGFSFPetg-----frsKVLESESPREVIEDFSRKP----------------- 223
XP_001897193 226 -------------------------CQSGFSFReta-----lvsRVFGSSFHHKEFDDFSKKP----------------- 258
XP_016660375 214 -------------------------VTQGYFH-------------KRSTSFTNSDISTSTTLP----------------- 238
Q9FMI8       280 ----------------------gqdCDCKEKIDededk--vlalTNGFGD-SSSFNGSSG-RSleieedfdrlairene- 332 thale cress
XP_009112116 259 ----------------------gqdCDCKEKIDgegdk--vlalTNGFVDSSSSLNGSSEIEAeeveeeeeeqvis---- 310
XP_004966258 253 ----------------------gqyCKCRFELD-----------DKELEEEEGDSLGSVSPMSleaengkeleeelarmh 299
5_pfamImport 197 -------------------------VSQAFPW-----------------HSNFLKVERTNDIR----------------- 217
XP_009014774 214 ----------------------------MFTK-------------TKKDNPNVESQADNNIMP----------------- 235
XP_015788203 231 trppadwkqilnqhpnsignlhnsaLIPDFPR------------------------------------------------ 262
XP_009014294 290 ------------------KIPFDESLIIEILVGIYYLMFNGLSKLCMQAVDDIHLRASYDLNYPVLLVTNAFLNSLHLNN 351
4_pfamImport 224 ------------------RQKVTAEFLNHLLRGCYLALFNGAADLALRAIDSIHMRAQYEMLPETLLVVNSLRNSLLDNM 285
XP_001897193 259 ------------------RLRISSQYLLESLNGLYFALFNGTPELAVQAVDAVHQRALYEFYADVILVTNSISETLLESN 320
XP_016660375 239 ------------------RIPLSPKFLIHLLYCLYISIFNCGKAEAFQALEDIYYRACYSCYCEVILLANAIKNSCQGSF 300
Q9FMI8       333 --eqlssngggggvgrgvRIPLPWELFQPTLRILGHCLL----------------------------------------- 369 thale cress
XP_009112116 311 ------sngvgvgvgggvRIPLPWELLQPILRILGHCLL----------------------------------------- 343
XP_004966258 300 ingtssgrncgekddkegRVPLPWELLQPVMRVLGHCLL----------------------------------------- 338
5_pfamImport 218 ------------------RVQITSSVMLSILRSVYFALYNGCRSYAISAIEAAKMRGCYEMCPKVQLFCNAVLNSTLQED 279
XP_009014774 236 ------------------KH-------------------NGQSEAGLMAVSSLYKRAHYDLLPASIMSIGALMSFISNAQ 278
XP_015788203 263 ------------------KIPVASQLLVRLSSCIYFCIYNGVGDVAIQALDHIHARGLSELYPDVLLMTNAIKHQLSTNP 324
XP_009014294 352 TSPdlsqedskSLSVTASPIQT--------------------------HRHskFP---KDAITNASFRTRKLPDD 397
4_pfamImport 286 WSK--------EKRGELMWTRP--------------------------QHKdmIRr--KDLVTNASLKMKRMPED 324
XP_001897193 321 FHK--------NEELTAQWVRP--------------------------GKLdnHKr--NEVVTNASLRLKKMPED 359
XP_016660375 301 EGgqt----pnVSSVGTPVSSN--------------------------TCStpVS---KSMITNASFRTKKLPDD 342
Q9FMI8       370 ----------------------------------------------------------------SPLNTEDVKDA 380 thale cress
XP_009112116 344 ----------------------------------------------------------------SPLNSEDVKDA 354
XP_004966258 339 ----------------------------------------------------------------APLNPVEVRDA 349
5_pfamImport 280 DQNlgn--splGLPTLLTPILS--------------------------RSSssVS---RHAVTAKSIKDHKWKHT 323
XP_009014774 279 NDEdddnngdnAATTTTTTTTSqlkkllprhlqqhdaqqkflsqqqsqQQQqqLT---REAITNATFRTQTMPED 350
XP_015788203 325 PTQsgd--cpaEIPVTFTPTST--------------------------VTSttSSssnKTAITNASFKTRKLPED 371
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