Conserved Protein Domain Family
RRM_SF

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cl17169: RRM_SF Superfamily 
RNA recognition motif (RRM) superfamily
RRM, also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA processing, RNA export, and RNA stability. This domain is 90 amino acids in length and consists of a four-stranded beta-sheet packed against two alpha-helices. RRM usually interacts with ssRNA, but is also known to interact with ssDNA as well as proteins. RRM binds a variable number of nucleotides, ranging from two to eight. The active site includes three aromatic side-chains located within the conserved RNP1 and RNP2 motifs of the domain. The RRM domain is found in a variety heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing, and protein components of small nuclear ribonucleoproteins (snRNPs).
Links
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Taxonomy: root
PubMed: 1915 links
Protein: Related Protein
Related Structure
Statistics
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Accession: cl17169
PSSM Id: 473069
Name: RRM_SF
Created: 13-Mar-2013
Updated: 4-Oct-2023
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