3R7W


Conserved Protein Domain Family
RagA_like

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cd11384: RagA_like 
Click on image for an interactive view with Cn3D
Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B
RagA and RagB are closely related Rag GTPases (ras-related GTP-binding protein A and B) that constitute a unique subgroup of the Ras superfamily, and are functional homologs of Saccharomyces cerevisiae Gtr1. These domains function by forming heterodimers with RagC or RagD, and similarly, Gtr1 dimerizes with Gtr2, through the carboxy-terminal segments. They play an essential role in regulating amino acid-induced target of rapamycin complex 1 (TORC1) kinase signaling, exocytic cargo sorting at endosomes, and epigenetic control of gene expression. In response to amino acids, the Rag GTPases guide the TORC1 complex to activate the platform containing Rheb proto-oncogene by driving the relocalization of mTORC1 from discrete locations in the cytoplasm to a late endosomal and/or lysosomal compartment that is Rheb-enriched and contains Rab-7.
Statistics
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PSSM-Id: 206744
Aligned: 32 rows
Threshold Bit Score: 403.516
Created: 27-Oct-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Structure:3R7W: Saccharomyces cerevisiae Gtr1p binds guanylyl imidodiphosphate, a non-hydrolyzable analog of GTP; contacts at 4.0A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               ####                                          #                       
3R7W_A      5 KLLLXGRSGSGKSSXRSIIFSNYsAFDTRRLGATiDVEHSHLRFLGNxTLNLWDCGGQDVFXENYFTKQKDHIFQx---V 81  baker's yeast
CBY21554   10 KVLLMGKSGAGKTSMRSIIFASYvADDVYRLGMTmDIEHAHVRMLGNlVVNLWDCGGQDSFMDSYFMFQKEQIFKg---C 86  Oikopleura dioica
EGP85103   14 KVLLMGRSGAGKSSMRSIIFSNYvAKDVRRLGATvDVEHANIKFMGNlMLNLWDCGGQDSFVESYLTNQRSHVFTs---V 90  Mycosphaerella gra...
CAD21343   29 KVLLMGKSGSGKSSMRSIIFSNYlARDTRRLGATiDIDLSHVKFLGNlTLNLWDCGGQEAFMENYLSQQRAHVFSn---V 105 Neurospora crassa ...
EAR88900    3 KLLLMGRQGAGKTSMHSIIFANYpARETMGIGYTvGVDQQLIRFMGNlTLNLWDCGGQDKLMKHYFHQQKETIFKd---V 79  Tetrahymena thermo...
CBH17257    7 KLLLMGPAGAGKTCMRSIIFDNYlPRDTLRLAITiSHEESRVRLLNNmYVNLWDCGGQQQYVAEYLNRQRECIFRn---V 83  Trypanosoma brucei...
CAI39282   10 KMLLMGQHKVGKTSMHSIIFANTpPNQVMQIGLTvDVNQNSFKFMGNlKINLWDCGGQDKLLQEYFTTQKSTIFSn---V 86  Paramecium tetraur...
EFP78845    9 KVLLMGKSGSGKSSMRNMIFANMaAADTRKLGATiDMETTPIKFLGHfALRLVDCGGQDSYMHNVLSMPARNRSSvfsqI 88  Puccinia graminis ...
EAL50844    8 KVLLMGRSGSGKTSMRTILFSNYlPTQTRQLQVTiDVNHSQISFLGNyTLNLWDCGGQKQFMDMYLGAQKSQTFKk---V 84  Entamoeba histolyt...
EFC38521    2 KLLLMGKNGSGKTSMRSILFAMTsPMECRKLAPTiDVEYIPIKLMENmKVNLWDCGGQQNMMLNYFKNRRESIFSq---V 78  Naegleria gruberi ...
Feature 1                                                             ## #                    
3R7W_A     82 QVLIHVFDVESt---------------EVLKDIEIFAKALKQLRKYSpDAKIFVLLHKXDLVQLDKREELFQIXXKNLSE 146 baker's yeast
CBY21554   87 EVLIYVIDVKSe---------------RPEADLQGYRDCLAAIADYSaNAKIFVLVHKMDLLLESEKNAIFEVKKKELEE 151 Oikopleura dioica
EGP85103   91 AVLIFVFDVSSk---------------EAASDMLSFASTIRALKEYSpNSKIFILIHKMDLIRPDQKHNIYGHKMRDIRA 155 Mycosphaerella gra...
CAD21343  106 GVLIYVFDIESr---------------DVDRDLATYVNIISALVQYSrEAKVFVLIHKMDLIQPMTREDVFDRRVALVRR 170 Neurospora crassa ...
EAR88900   80 EVLIYVFDVDKqg-------------mDLEEDLTTYRVCLENLAELSeGAKVFVLIHKMDKIQPNQQKEVLERKKQEISS 146 Tetrahymena thermo...
CBH17257   84 GVLLFVFDISSmsceesdvfggktseqNWTDTFQYFREAVQHVRTYSpQAKVFVLLHKMDIIQQKLRSSIFESRKREILK 163 Trypanosoma brucei...
CAI39282   87 EVLIYVFDVDKeg-------------dLFIKELNDFKTTVTSLSECSpGAIVFVLIHKFDKIKESERKIVFERKYKEIIQ 153 Paramecium tetraur...
EFP78845   89 GCLLYVFDVESpdfs--------tidmIWFSRVISAILETLSESENMeEFKLHILIHKMDLVPEEHRQVVFESKAKEVRN 160 Puccinia graminis ...
EAL50844   85 EALIYVFDVTSe---------------TFDKDIQEYRAVLERLYEYSpDAKLFTLIHKMDVFEEDEKDYQYLQKEGKIKL 149 Entamoeba histolyt...
EFC38521   79 NALVYVFDVSTd---------------GDEEVLRDFHESLQALGENSsNTKVFCLLHKTDVLIPSEREKILQRKEKEIMA 143 Naegleria gruberi ...
Feature 1                                                                    ###              
3R7W_A    147 TSSEfg------------------------------------------------fPNLIGFPTSIWDESLYKAWSQIVCS 178 baker's yeast
CBY21554  152 IAHTn-------------------------------------------------rLNVDIAKTSIWDKTLYSAWSKIVTQ 182 Oikopleura dioica
EGP85103  156 TCDDegf----------------------------------------------hsAQVDFCPSSIWDQSLYKAWTQVIYF 189 Mycosphaerella gra...
CAD21343  171 KTAEavaivrkqkpevsgvgvgglpgpggggggggammagslpspelstpipdleVEMQLFATSIWDQSLYKAWASIIHD 250 Neurospora crassa ...
EAR88900  147 QCSDsr------------------------------------------------vNVLGFFATSIWDETLYKAWSSIVQQ 178 Tetrahymena thermo...
CBH17257  164 EVENvgg----------------------------------------------sgGDVQFFATSIYDDTLYLAYSNIVRS 197 Trypanosoma brucei...
CAI39282  154 RADGln------------------------------------------------iEIKDVFSTSIWDETLYKAWSQIVQN 185 Paramecium tetraur...
EFP78845  161 KVEDyskg-------------------------------------------kisaDMIHIFSTSIWDETIYKAWSTIVQM 197 Puccinia graminis ...
EAL50844  150 VSKP---------------------------------------------------FRVVSYPTSIYDDTLYSAWSAITYS 178 Entamoeba histolyt...
EFC38521  144 VAEL---------------------------------------------------TDLTCFRTSIWDESLYRAWGSILNT 172 Naegleria gruberi ...
Feature 1                                                                                     
3R7W_A    179 LIPnxsNHQSNLKKFKEixnalEIILFERtTFLVICSsngensnenhds---------sdnnnvlldpkRFEKISNIXKN 249 baker's yeast
CBY21554  183 LIPkkeKFQTELQNLAEqsganEVLLFEKaTMLNICYikndanghkt-------------eddedliaeRMEGLSHYLKN 249 Oikopleura dioica
EGP85103  190 LVPnanTIESMLQRLADlldarEMILYERtTCLVVTHitrgnee-------------------rnpytdRFERISSILKT 250 Mycosphaerella gra...
CAD21343  251 LVPnlsVIETQLASLGVaidadEILLFERtSFLVVSKwtspege-------------------snpygdRFERMSNILKA 311 Neurospora crassa ...
EAR88900  179 MVPnmqFIKQQLKEFSDlcdadEVVLFEKqTFLIIAFydkhe-----------------------rgmmKYERVSNIIKQ 235 Tetrahymena thermo...
CBH17257  198 LIPhcdVLTRAMEKLLVscnasEVALYERgTFLCLTYvskidaggadngsliaeddgsnrgdrcsgtesRTTKVSETVKH 277 Trypanosoma brucei...
CAI39282  186 LIPninIIKESLKAFCQtcsceEVVLFEKsTFLIIDFqetne----------------------kkdiqKYERLSNIIKQ 243 Paramecium tetraur...
EFP78845  198 LIPeigSLHAPLERFAKftsacEVIVFETaTSLVVARwtdndate----------------qiqavderRFERASAVVKA 261 Puccinia graminis ...
EAL50844  179 LIPmitEVEDKLNSFCNfieadEIVVYEAsSLLVISYssrve----------------------fdesrRFENISTSIKS 236 Entamoeba histolyt...
EFC38521  173 LIPqinEIKSKLEEFAKicgaeEVVLFERsTFLLISQwsnekv---------------------tqddhRFEKIANITKQ 231 Naegleria gruberi ...
Feature 1                                                                    
3R7W_A    250 FKQSCTKl------kSGFKTLILnn----nIYVSELSsNXVCFIVLkdxn-ipqELVLENIKK 301 baker's yeast
CBY21554  250 FKLICWRk------aTNFESLEIrts-tfsAIMQIFTdYTCIMLVSfn-----pDIPMWNWRK 300 Oikopleura dioica
EGP85103  251 HKHSMSKhtgtmaseVSFAEMQIktg-sfmFFITRLTeNTNLAVVMps-----dEACFNAARN 307 Mycosphaerella graminicola IPO323
CAD21343  312 WKHTCSKytgtprnaEQFSDFEYkmganfsMFVTKFTtNTYILVCMppge-arfNSAKLNVAA 373 Neurospora crassa OR74A
EAR88900  236 FKLSCVKl------gANIQGITVknk--fsSTIQEFNeNSFIMVVYsdpr-isqGAIDYNLQY 289 Tetrahymena thermophila
CBH17257  278 FKLSCMNn------aTSLEGYQMttt-tftALLHPFTsCTYVLIFSedts-vnvELHRINVLS 332 Trypanosoma brucei gambiense DAL972
CAI39282  244 FKLTCMKt------qASIQAITVkse-kftVYIDEFTeNTFIMLAYtdps-iypAAISHNVHH 298 Paramecium tetraurelia strain d4-2
EFP78845  262 FKSASARi------rSRFKSMEIthp-mytAVLDSLTeTTAILVVAvdpk-vvpAAIHLNINL 316 Puccinia graminis f. sp. tritici CR...
EAL50844  237 FYHSCTDlk-----kTQFKNIRVelp-dkkVYFDTFTsSTFIMVIFsnpc-ltfTNVAMNVKA 292 Entamoeba histolytica HM-1:IMSS
EFC38521  232 FKLSCSKa------hSQLSSMELvks-dfsAFFEEFTmNTFIMVIVsaesklesEMVKMNIRL 287 Naegleria gruberi strain NEG-M

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