Conserved Protein Domain Family
GT29_ST3GAL5

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cd23983: GT29_ST3GAL5 
beta-galactoside alpha-2,3-sialyltransferase 5
ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).
Statistics
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PSSM-Id: 467711
Aligned: 7 rows
Threshold Bit Score: 369.453
Created: 28-Nov-2018
Updated: 27-Apr-2023
Structure
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Aligned Rows:
 
putative active
Feature 1:putative active site [active site]
Evidence:
  • Comment:based on homology to other members of the family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                ###                    ##                    #                          
Q9UNP4       191 TCRRCVVIGSGGIlhgleLGHTLNQFDVVIRLNsAPVEGyseHVGnKTTIRMTYPEgaplsdleyysnDLFVAVLFKSVD 270 human
NP_001165301 137 HCKRCIVIGSGGIlhgleLGQMVDQFDIVIRLNnAPVHGyaqDVGnKTTIRMTYPEgapvseqeyqhsSLFVTVLFKHAD 216 western clawed ...
XP_006003188 136 PCKHCVVIGSGGVlrglgLGNVLDHFDIIIRLNaAPVRGfsnDVGsKTTIRMSYPEgapkskheyhpqTLFVAVMFKSVD 215 coelacanth
CAF04061     136 DCRRCVVVGNGGIlkglgLGHLLNRFDIIIRLNsGPLQDfsaDVGnRTTIRMSYPEscpkvwedtdpdLKYVAVIFKSVD 215 zebrafish
AFK11311     169 GCRRCVVVGNGGIligskLGPYIDQHHIVIRMNnGPVVGyeqDVGsKTTLRITYPEgasktpidydpkSLFVAVIYKSAD 248 elephant shark
NP_001004016 165 TCRRCVVVGSGGIlhgknLGAHIDQYNIIIRVNnAPVFGfesDAGsRTTIRLIYPEgapshiqeyertEVVALVVFKSLD 244 zebrafish
NP_001001192 136 HCKRCVVIGSGGIlygseLGHLLNQYDIVIRLNdAPVQGytdHVGnKTTIRMTYPEgaplseheyppaSLFVAVLFKSVD 215 chicken
Feature 1                                                                             ###        
Q9UNP4       271 FNWLQAMVkketlpfwvrlffwkqvaekiplqpKHFRILNPVIIKETAFDILqysepqsrfwgrdknvPTIGVIAVVLAT 350 human
NP_001165301 217 FRWLEAVLknqklsawnrfffwkrvtdkiplnsSQFRVLNPLIIKETAIDILgfpkpqkrwlgwdknvPTIGMTAVILAT 296 western clawed ...
XP_006003188 216 FSWLKAMIknetlsfwsrlffwqevatripinpSQFRILNPLIVKETALDMLqypeprhtlwswdqnvPTLGATAVVLAT 295 coelacanth
CAF04061     216 FHWLRAMIsrtpvslwdrlffwqnvpmsvpvktSQFHLLNPQIIREMALDLLnypepkkrlwswdqniPTLGLTALNLAT 295 zebrafish
AFK11311     249 FAWLKAVVskkpmtfaeklwfwqsvvesiplkvENFRIFNLDIIRETALNFLsypdphss-qwkwmkhPTLGVTSIITAL 327 elephant shark
NP_001004016 245 LAWMTSVVtkeplswwsklwfwkdvidsiplqpENVRILNPEIMYRTGQVLQtyaeq------qrkmvPTLGITAVVVAL 318 zebrafish
NP_001001192 216 FNWLQAMVknetlslwirlffwkevakkipftsKQFRILNPVIVKETALDILefpkprsifwgwdknvPTIGVMAVVLAT 295 chicken
Feature 1                 ##         ###               #            
Q9UNP4       351 HlCDEVSLAGFGYdlnqprTPLHYFDSQcmaamnfqtmHNVTTETKFLLKL 401 human
NP_001165301 297 HlCDEVNLAGFGYdlsqpdASLHYYDNRcmnsmndqpmHDVTKEKKMLRTL 347 western clawed frog
XP_006003188 296 HmCDEVSLAGFGYnlsqphTPLHYYENIsmnamkgqtmHNVTREHLFLQKL 346 coelacanth
CAF04061     296 YiCDEVSLAGFGYnlsqkeAPLHYYDSVpmttilkeamHNVQKETVFLKRL 346 zebrafish
AFK11311     328 HlCDEVNMAGFGYdmnqlhLPMHYYETVsmaamnaqamHDISLEKLFLLSL 378 elephant shark
NP_001004016 319 QvCDEVSIAGFGYdlqhpgAPLHYYGSLrmdamktqvvHDVSAETVFLKEL 369 zebrafish
NP_001001192 296 HlCDEVSIAGFGYdlnqpsTPLHYYNNLcmaamnrqtmHNVTGETKLLQKL 346 chicken

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