4WD6,2YNT,1DD6,1WUP


Conserved Protein Domain Family
IMP_DIM-like_MBL-B1

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cd16301: IMP_DIM-like_MBL-B1 
Click on image for an interactive view with Cn3D
IMP-1, DIM-1, GIM-1, SIM-1, TMB-1 and related metallo-beta-lactamases, subclass B1; MBL-fold metallo-hydrolase domain
Includes the acquired MBLs IMP-1(a beta-lactamase that is active on imipenem), DIM-1 (Dutch imipenemase), GIM-1 (German imipenemase), KHM-1 (Kyorin Health Science MBL 1), SIM-1 (Seoul imipenemase), and TMB-1 (Tripoli metallo-beta-lactamase). IMP-1, DIM-1, GIM-1, SIM-1, and TMB-1 are Class 1 integron-mediated MBLs, KMH-1 is plasmid-mediated. MBLs (class B of the Ambler beta-lactamase classification) are a diverse group of metallo-enzymes that are capable of catalyzing the hydrolysis of a wide range of beta-lactam antibiotics. MBLs have been divided into three subclasses B1, B2 and B3, based on sequence/structural relationships and substrates, with the B1 and B2 MBLs being most closely related to each other. This subgroup of acquired MBLs belongs to the B1 subclass. B1 enzymes are most active with two zinc ions bound in the active site, and have a broad-spectrum substrate profile.
Statistics
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PSSM-Id: 293859
Aligned: 20 rows
Threshold Bit Score: 350.814
Created: 15-May-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1DD6 : Pseudomonas aeruginosa IMP-1 metallo-beta-lactamase binds a mercaptocarboxylate inhibitor and two zinc ions

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                       # #        #  ###                 #                         # 
4WD6_A      5 PELRIEKVKENIFLHTSYSRVNg------FGLVSSNGLVVIDkgNAFIVDTPWSDRDTETLVHWIRKNgYELLGSVSTHW 78  Pseudomonas stutzeri
1DD6_A      5 PDLKIEKLDEGVYVHTSFEEVNg------WGVVPKHGLVVLVnaEAYLIDTPFTAKDTEKLVTWFVERgYKIKGSISSHF 78  Pseudomonas aerugi...
AAT90846   27 GQLSISKLADGVYLHHSYKNVSn------FGLVEANGLVVIKdkQAFIIDTPWTDNDTQKLVDWITQQgFIPVASISTHS 100 Shewanella livings...
ABI70740   40 KANQAQATQIQLFEYQSYFKTDd------FGLVDANGLVVVEgkDAYLIDTPWSEKDTIALVEWIKQQnFILKASISTHS 113 Shewanella frigidi...
KJE42032   23 KQLKIKKLSDNVYQHISFKRVKp------WGLVEASGLVVINgtEVHMIDTPWTTQGTKELIEWIEAKgLTLKNTVVTHF 96  Thalassomonas acti...
KJY88596   21 STLVVTPIAEHVYKHESSLHVEp------WGLVAGSGLVVVDgqDAYIVDTPWTEQDTEVLLLWAEDRkLNVKGAVVTHY 94  Pseudoalteromonas ...
ABL99385   20 QALEITPLSDGLFLHQSEKEVEg------FGKVSANGLIIVDgkEAFVVDTPWTDADAEALLEWTKAKdLTVKAVLATHW 93  Shewanella amazone...
ABE56430   22 SKLKIVQLSDIVYQHTSLSDGDa------YGVMAANGLIVIVgkQAYLIDTPWTEADTNTLIQWVTVKgLTIGGVIVTHF 95  Shewanella denitri...
ERG53131   28 PKLTIKPIQNGVYEHISYQHVGq------WGNVSARGLVVVDgkEAYMIDTPWSNSDTEKLINWTNEQgFTLKAAVVTHF 101 Pseudoalteromonas ...
CAQ78899   27 KPLQFEEITNNVFLVKSYREFKnlqspkkPILVDANSLVYVDgkDAYLIDTPWNASNMPQLMTWIENRgLTLKKTVFSHF 106 Aliivibrio salmoni...
Feature 1     # #                                                         #                  #
4WD6_A     79 HEDRTAGIKWLNDQSISTYATTSTNHLLKENkKEPAKYTLKgnESTLVDgLIEVFYPGGGHTIDNVVVWLPKSKILFGGC 158 Pseudomonas stutzeri
1DD6_A     79 HSDSTGGIEWLNSRSIPTYASELTNELLKKDgKVQATNSFSgvNYWLVKnKIEVFYPGPGHTPDNVVVWLPERKILFGGC 158 Pseudomonas aerugi...
AAT90846  101 HQDRAGGIGYLNRQGITTTVSETTQQILTENdKTTAKSTFTgmQYIMKTdLVEVYDLGAGHTKDNLVVWLPTQQILFGGC 180 Shewanella livings...
ABI70740  114 HADRTAGISYLNSIGVSTHVSAMTQKILTTQhKALASQPFDgdSFTLANgLLEARYLGAGHTIDNIVVWLPKAQLLFGGC 193 Shewanella frigidi...
KJE42032   97 HEDASGDLPLLNDLKIKTYATSLTNKLLKSNrKETSSDEISsnTFELADgVVSIFYPGAGHTEDNIVVWVPKEKILFGGC 176 Thalassomonas acti...
KJY88596   95 HQDASGGLAVLNKHQIPTYASAQTNHLLAQKhSEIALHNLPqaSSVIKSgVVETYYPGAGHSKDNIVVWLPQSKILFAGC 174 Pseudoalteromonas ...
ABL99385   94 HEDRAGSFGVFERAGIATLSSEATQALLRQHqKTLATHTFSgdEIQYFGnKVEVFYPGAGHAMDNLVVYLPHEKLLFGGC 173 Shewanella amazone...
ABE56430   96 HQDSSGGLAVLNKLKINTYATTLTNQLLKANnREPASNEITseTFDLVPgVIQAYYPGAGHTQDNLVVWLAKSNLLFGGC 175 Shewanella denitri...
ERG53131  102 HQDASGGLTALNQRNIPTYAYKKTNQLLEKHkGLSATHIIEedKFSLLKdKIEVFYPGGGHTADNIVVWLEKPQILFAGC 181 Pseudoalteromonas ...
CAQ78899  107 HEDQTGGLEYLQEHHFETYASALTNKFLKGDnKKATNHQFSgdNFVLLEnKIEVFYPGGGHTKDNAVVWLPKEKVLLGGC 186 Aliivibrio salmoni...
Feature 1       #     ####                             #                     
4WD6_A    159 FVRsldsEGLGYTGEAHIDQWSRSAQNALSRYSEAQIVIPGHG-KIGDIALLK-HTKSLAETA 219 Pseudomonas stutzeri
1DD6_A    159 FIKp---YGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSeVGDASLLKL-TLEQAVKGL 217 Pseudomonas aeruginosa
AAT90846  181 LIKslnsSTLGYTGEADLQQWPLTIAKVQAQFPQVKIVVPGHG-QVGDKALLE-HTIELLIPK 241 Shewanella livingstonensis
ABI70740  194 LVKsahsKSMGYIAEASLTDWPVTISKVKATFVDAEVVVPGHG-AIGNAGLLN-HTQELVNIY 254 Shewanella frigidimarina NCIMB 400
KJE42032  177 FVKslhaKSLGNTGDAVIGEWSNSIQKVINRYPDIKLVVPGHG-KVGDVSLLT-HTQKLALSA 237 Thalassomonas actiniarum
KJY88596  175 FVKsvasKNLGNLEDASVDEWQASIHKVLSRYPEINMVIPGHG-KEGDLSLLH-HTVKLIKIE 235 Pseudoalteromonas piscicida
ABL99385  174 LVReastRFMGFYGDGSLPDWPESMSRLIAKFPEVITVVPGHG-ALGDKRLLE-HTRGLAEAA 234 Shewanella amazonensis SB2B
ABE56430  176 LVQsfnnRKLLNIEDASIKDWPKSLQNVMVKYPNIDMVIPGHG-QIGDVSLLE-LTQQLARKA 236 Shewanella denitrificans OS217
ERG53131  182 FVKglnsKNLGNLEDARVSKWPTSIENTLSAYPNIKHVFPGHG-RAGDQSLLL-HTAKLAKNY 242 Pseudoalteromonas spongiae UST01072...
CAQ78899  187 LMRanevNTIGWTGDADMKAWAGSAQKVLTKYPQANFVVPGHG-NVGEGTSIIsHTVDITGKI 248 Aliivibrio salmonicida LFI1238

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