5E6P,2DLS


Conserved Protein Domain Family
PDZ_ARHGEF11-12-like

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cd23069: PDZ_ARHGEF11-12-like 
PDZ domain of ARHGEF11, ARHGEF12, and related domains
PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain of ARHGEF11, ARHGEF12, and related domains. This subfamily includes the GEFs (guanine exchange factors) ARHGEF11 (Rho guanine nucleotide exchange factor 11, known as PDZ-RhoGEF) and ARHGEF12 (Rho guanine nucleotide exchange factor 12, also known as leukemia-associated RhoGEF). GEFs activate Rho GTPases by promoting GTP binding. ARHGEF11/12 are regulators of G protein signaling (RGS) domain-containing GEFs; the RGS domain mediates their binding to and activation of Galpha (and Gq also in the case of ARHGEF12), in response to G-protein coupled receptor activation. ARHGEF11 and 12 are involved in serum-signaling, and regulate Yes-Associated Protein (YAP1)-dependent transcription. The ARHGEF12 PDZ domain binds plexin-B1 and the receptor tyrosine kinase insulin-like growth factor receptor (IGF-R1) beta-subunit. ARHGEF12 also interacts with glutamate receptor delta-1(GluD1), a postsynaptic organizer of inhibitory synapses in cortical pyramidal neurons. The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This ARHGEF11-12-like family domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.
Statistics
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PSSM-Id: 467282
Aligned: 18 rows
Threshold Bit Score: 127.894
Created: 1-Jun-2021
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
 
peptide binding
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on canonical PDZ domains with structure
  • Comment:PDZ domains specifically recognize and bind to short C-terminal peptide motifs, but can also recognize internal peptide motifs and certain lipids
  • Structure:5E6P: PDZ domain of human ARHGEF11 binds the cytoplasmic region of PlexinB2; contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                     #######       #  #                            #   #  ##          
5E6P_B          8 QRCVIIQKDq-hGFGFTVSGDrIVLVQSVRpGGAAMKAGVKEGDRIIKVNGTMVTnsSHLEVVKLIKSGaYVALTLL 83   human
2DLS_A          9 QRCVIIQKDq-hGFGFTVSGDrIVLVQSVRpGGAAMKAGVKEGDRIIKVNGTMVTnsSHLEVVKLIKSGaYVALTLL 84   human
XP_013071185  117 QRCVIIQRDe-kGYGFTVSGDnPVFVASVKaDGAASKAGVQQGDRIVKVNGTLVTsrNHLDVVKLIKSGsYVALTLL 192  Biomphalaria gla...
EEC18542       70 QRCLIVRRDe-kGYGLTVSGDnPVFVQSVKpDGAAARAGVHQGDRIIKVNGTLVTqsNHQDVVQLIKSGaHVALTLL 145  black-legged tick
NP_001027010   48 QRCVVVQRDn-lGFGFTVCGErIKLVQNVRpGGAAVKAGVQEGDRIIKVNGSMVSsmSHQEVVKMIKSGtYVALTLQ 123  zebrafish
XP_002118052   18 QRIVTIFRDqqnSYGFTVSGDnPVFVQSVReGGPAYNAGIQRGDRIVKVNKKLVThaHHQDVVQMIKGVeSVTLTLF 94   Trichoplax adhae...
XP_012560154   12 QRCVVIHRDe-nGYGLTVSGDnPVYVQSIKeNGAAANAGVQVDDQIIKVNGMVVSqsNHLEVVSLIRSGsFVALTLL 87   Hydra vulgaris
AAR30497        3 ERCVVVQRQp-dGFGLTVNSEfPVYVHTLKqDGAAYCAGVRQGDRIVKVNGMSVSpnNHKEVLQMISNGhNVALTLL 78   nematode
XP_009021991  604 TKCVVLQKEe-sGYGFTVMGTdPVYVSHVReNGAAYRAGIQEGDKVIKVNGTLVAhfNHIDVTNMMKSN-QVKIMRN 678  Helobdella robusta
O15085         45 QRCVIIQKDq-hGFGFTVSGDrIVLVQSVRpGGAAMKAGVKEGDRIIKVNGTMVTnsSHLEVVKLIKSGaYVALTLL 120  human

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