4DKL


Conserved Protein Domain Family
7tmA_Mu_opioid_R

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cd15090: 7tmA_Mu_opioid_R 
Click on image for an interactive view with Cn3D
opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.
Statistics
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PSSM-Id: 320218
Aligned: 5 rows
Threshold Bit Score: 461.386
Created: 15-Dec-2013
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 41 residues -Click on image for an interactive view with Cn3D
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Opioid receptors respond to classical opioid alkaloids such as morphine and heroin, as well as to endogenous peptide ligands like dynorphins, enkephalins, endorphins, endomorphins and nociceptin.
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracellular surface of its receptor.
  • Structure:4DKL: Mouse mu-opiod receptor binds a morphinan antagonist, contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                               #  ##           ###### ##
4DKL_A        18 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTaTNIYIFNLALADALATSTLPFQSVNYLMGtWPFGnilCKIVISIDY 97 
AAK01143      63 ITALYSIVCVMGMGLVGNVLVMYVIIRYTKMKTaTNIYIFNLALADSLATSTLPFQSVNYLMGtWPFGdelCKIVMSIDY 142 zebrafish
P35372        71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTaTNIYIFNLALADALATSTLPFQSVNYLMGtWPFGtilCKIVISIDY 150 human
XP_003641008  86 IAIMALYSVVCVVGLFGNFLVMYVIIRYTKMKTaTNIYIFNLALADALATSTLPFQSVNYLMGtWPFGtilCKIVISIDY 165 chicken
XP_002933909  70 IIITALYSMICVMGLFGNVLVMYVIVRYTKMKTaTNIYIFNLALADALATSTLPFQSVNYLMGtWPFGnivCKIVISIDY 149 western clawed ...
Feature 1          #                                            # #####                          
4DKL_A        98 YNMFTSIFTLCTMSVDRYIAVCHPvkALDFRtPRNAKIVNVCNWILSSAIGLPVMFMAttk---yrqGSIDCTLTFshpt 174
AAK01143     143 YNMFTSIFTLTTMSVDRYIAVCHPvkALDFRtPRNAKIVNVCNWILSSAIGLPVMVMAsttsdlhsnGIIDCTLLFphps 222 zebrafish
P35372       151 YNMFTSIFTLCTMSVDRYIAVCHPvkALDFRtPRNAKIINVCNWILSSAIGLPVMFMAttk---yrqGSIDCTLTFshpt 227 human
XP_003641008 166 YNMFTSIFTLCTMSVDRYVAVCHPvkALDFRtPRNAKIVNVCNWILSSAIGLPVMFMAttk---yrqGSIDCTLTFshpa 242 chicken
XP_002933909 150 YNMFTSIFTLTTMSVDRYIAVCHPvkALDFRtPRNAKIVNVCNWILSSAIGLPVMFMAttk---serGSTDCALLFphps 226 western clawed ...
Feature 1           #  ### ### ##                                                                
4DKL_A       175 WYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKsvrnifemlrideglrlkiykntegyytigighlltkspslnaak 254
AAK01143     223 WYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKsvrml---------------------------------------- 262 zebrafish
P35372       228 WYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKsvrml---------------------------------------- 267 human
XP_003641008 243 WYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKsvrml---------------------------------------- 282 chicken
XP_002933909 227 WYWDNLLKICVFIFAFIMPVLIITVCYGMMILRLKsvrml---------------------------------------- 266 western clawed ...
Feature 1                                                                                        
4DKL_A       255 seldkaigrntngvitkdeaeklfnqdvdaavrgilrnaklkpvydsldavrraalinmvfqmgetgvagftnslrmlqq 334
AAK01143         --------------------------------------------------------------------------------     zebrafish
P35372           --------------------------------------------------------------------------------     human
XP_003641008     --------------------------------------------------------------------------------     chicken
XP_002933909     --------------------------------------------------------------------------------     western clawed ...
Feature 1                                                                     #  ## ##  #        
4DKL_A       335 krwdeaavnlaksrwynqtpnrakrvittfrtgtwdayeKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALitipet 414
AAK01143     263 ----------------------------------sgskeKDRNLRRITRMVLVVVAVFIVCWTPIHIFVIIKALvtipns 308 zebrafish
P35372       268 ----------------------------------sgskeKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALvtipet 313 human
XP_003641008 283 ----------------------------------sgskeKDRNLRRITRMVLVVVAVFIICWTPIHIYVIIKALvnipet 328 chicken
XP_002933909 267 ----------------------------------sgskeKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALinipps 312 western clawed ...
Feature 1          ## ###  #  ##                     
4DKL_A       415 tfQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 450
AAK01143     309 llQTITWHFCIALGYTNSCLNPVLYAFLDENFKRCF 344 zebrafish
P35372       314 tfQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349 human
XP_003641008 329 tfQTVSWHFCIALGYINSCLNPVLYAFLDENFKRCF 364 chicken
XP_002933909 313 lfQTVTWHVCIALGYTNSCLNPVLYAFLDENFKRCF 348 western clawed frog

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