Conserved Protein Domain Family
FAP206
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pfam12018: FAP206 
Domain of unknown function
This domain of about 280 residues is found in eukaryotes. There are two conserved sequence motifs: GFC and GLL. This family is also known as UPF0704. This domain is found in FAP206, a protein associated with cilia and flagella. In the ciliate Tetrahymena, the cilium has radial spokes, each of which is a macromolecular complex essential for motility. A triplet of three radial spokes, RS1, RS2, and RS3, is repeated every 96 nm along the doublet microtubule. Each spoke has a distinct base that docks to the doublet and is linked to different inner dynein arms. Knockout of the FAP206 gene results in slow cell motility and the 96-nm repeats lack RS2 and dynein c. FAP206 is probably part of the front prong and docks RS2 and dynein c to the microtubule.
Links
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Statistics
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PSSM-Id: 463432
Aligned: 44 rows
Threshold Bit Score: 170.14
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EEY60522            238 DIQESVAALAKLVRDEVRDANEICTQ-YTEVLLHVhhqlgtgeeaHSAEPSPSLDEIARWQDELSNRRQFLSYLQSLEED 316
XP_029345808        222 ELRDSFKKVMMTTSWILQ-----CYKvYTEILAPIfv-------iRINFATVTIKKLNDYKTVLVFYLQYQKNLEIIKND 289
Q57VI3              214 KAELLMSSLREHIEKELEEAISACAR-YVAVLRSPst------pvEGSMREAICAEYHRQLQLLLNIRMAKQQLDTLNNQ 286 Trypanos...
EDW02429            218 DLEMAQSNTNAGFNAALERLKNLCDRcQTAVSDQLqfn----ckeTQLLYRVPLEQLHRINQFTVTFYMLQRCLTALKRS 293
XP_002059457        218 ELQMAQSNTSAAFDAVLERLKDLSGKcQAAISEQLqfn----ckeTTLYYRVPLEQLQRINQFTVTFNSLMRCLLELQRS 293
XP_002004300        218 DLQMAQANTNAAFDAALERLKELSSRcQTAISEQLqfd----ckeTTLYYGVALAQLDRINQFTITFNMLMRCLVALQSS 293
WGS:AAQB:GK21484-PA 217 DLEMAQTNTEEAFHTALKQASQMRSFcQMAVEENIkid----andMTLSYRVPLERLQRLNQFSLMYAMFYRCLNTLHLS 292
WGS:AAPP:GF12186-PA 216 DLEMAQKNTETAFAASMEKANGVRNIcQALLEELVtid----smaETISYKVPLEHMDRLNQFSLTYCMLHRCLTTLNSN 291
ESS35660            149 DLPLSIEQEIEEGEKQIQELVKILLH-SPVLLAKA-------------GSETAEQDLALISAQHIYMTQLNAYRRALLTA 214
EAY02324            211 EVPKKLNAAKDRITTSIEGVNSLIIE-YNKALKDE-----------------NVPNAKRLTDELANRQQFNFFYEFLLTR 272

EEY60522            317 IAFSHEKVGTRLQMFQADMSALQNLVGART----------SLPKSHVYPLFEAVSHSWAELHQEHELLQ---ARARALRS 383
XP_029345808        290 LNKLKIELPALLIKFNIILKEIKQ-LKNTN----------DFGEDTICPEFNNVTIIWSEIRGIMNHLS---ITCNLILT 355
Q57VI3              287 I------FGELLPSYEAALEAVKDVLGTRSmrsdgvslrkNVSKATVYPKFIELAEVYEEAQRSFQSFEdikALMTLSLS 360 Trypanos...
EDW02429            294 YEHTAYLVSVETGRYECVVAKINDTLSMRT----------SIQSELIFPHFVYLSKVWSNLNHYFNHIV---ELNKLREQ 360
XP_002059457        294 YEHTAYMVSVESGRYNCVIAKINDTLYMRS----------AIDSELIFPHFVYLSKVWGNLNHYFNHIV---ELNRLREQ 360
XP_002004300        294 YEHTTYLLSVETGRYDCVVAKINATLAMRT----------SIESELIFPHFVYLAKVWANLNHYFNHIV---ELNKLRER 360
WGS:AAQB:GK21484-PA 293 YENTKYLVNVEQKRYQCVIAKINDTLSMRT----------AIESELIFPHFVYLSQVWTNLNNFLNHIV---ELNKLREH 359
WGS:AAPP:GF12186-PA 292 YQTTAYLIEVELKRYNCVVAKINETLSMRT----------AIESELIFPHFVYIAQVWGNLNNFLHHIV---ELNKLREQ 358
ESS35660            215 FLHTRHHLKEAVSECMSEIVGVGEELNSQP----------CTSRDDVFPKFSRIAVSYRKAFQENEKLC---SLNCLVAF 281
EAY02324            273 LKDISVGVEKSTIEFDSIIENLRNQMEISD----------SVPTQKSMPYFAALAEVWHKLKGCEDQVQ---TIENLLAR 339

EEY60522            384 LLRFKstftrtlsses-------pivrqarrggsIPPEDLFSHVETFPVEsQLAVdgktrsfglegedldgdeDNSNPSE 456
XP_029345808        356 MKQLTyeinniseei---------nnksimdtilTDTEELYTIFETYPLHpMCE-------------------------- 400
Q57VI3              361 LGKVS------------------------------NSSLPPTLLQEAINLeKEDGpadrcs------tearfeSIVTASL 404 Trypanos...
EDW02429            361 LEQQVtkemthrakdt--------itqiqdlakrRKDWFECSFFERMDALkKYQt------------------------- 407
XP_002059457        361 LECQVpkemeqrakdt--------imeiqdlskhIKEMRECSFNERMELLkKYQt------------------------- 407
XP_002004300        361 VEAQItsgmvqrsket--------iaeiqelakrHSEMRKCSFNQRMDTLkKFQt------------------------- 407
WGS:AAQB:GK21484-PA 360 LESLIpmdikslaest--------vaeilairqrIKSDSVVSFDERMAALkMHQt------------------------- 406
WGS:AAPP:GF12186-PA 359 LEALVvddlvtmtknt--------iaelqalnkrIKTPKVVTFDERMNAVkGLKt------------------------- 405
ESS35660            282 LASLAgehtldvasnvesacrrvhgifasvgqgdQEECRGVRSAENAEKErDDN-------------------------- 335
EAY02324            340 LRKHRdtftysistvd-------etaptiptpqqTPPTEKEVIPKESEVAgDDS-------------------------- 386

EEY60522            457 EE---GSGfpiRMPVES-TPEFMQL-PLD----YQGFCPWTVVERGGLLL--------PGDPSLGVVQYRN----AYHVF 515
XP_029345808        401 -----------WHPPTTsTDDTRNL-FAD------GYCVVMIVETDGTLI--------KHDKSLGVIQYSD----EWFGF 450
Q57VI3              405 PTkldRVFy---------ARDAETLrARSavcaLNGMCPVTLLE-DGLCVegrvgsrdPAFPGFVMRSEVDnervEWYAF 474 Trypanos...
EDW02429            408 ------------------DGNFCSLaKAD----IKEFCGLTLAVTNGLLL--------PAKVQRKLCMNVD----IKFGF 453
XP_002059457        408 ------------------DGNFCSLaEAD----IKEFCGLTLAVTNGLLL--------PAKVLRKLCMNLD----IKFGF 453
XP_002004300        408 ------------------DGNFCSLaQAD----IQEFCALAMAVTNGLLL--------PAKVVRKLCMNVD----IKFGF 453
WGS:AAQB:GK21484-PA 407 ------------------DGNFCNLaRAD----INEFCALTLTITNGLIL--------PAHVQRKLCMNVN----ISFGF 452
WGS:AAPP:GF12186-PA 406 ------------------DGNFCNLaKAD----IKEFCGLFMTMTNGLLM--------PAKVIRKLCSNMD----ITFGF 451
ESS35660            336 -----EVErpdGEPPR----------EFDgkfeLGGNCAWCLAKYAALV---------PADRSIAAISYGG----DAYAF 387
EAY02324            387 ------------------HPVLVQH-DADgefaFNGFCPVTLVERNGLLL--------PGDVVLGSIKWEK----RYYAF 435

EEY60522            516 VNERALGEFMIHPRRYVQGVLRRAGRQPALIYLLRLQES-FP 556
XP_029345808        451 ASIQAALHFGTKPTYYLYHFLNLMRSKTHLLSFFHLYEQ-MA 491
Q57VI3              475 QTASKLLRFAASSQRFVDHAKTLVKSNMVMVGLFGLVDLlPR 516 Trypanosoma brucei
EDW02429            454 QDETYARIGELWFERFITALRQAIFNSANLALLFKLDDA-LI 494
XP_002059457        454 QDETYARIGELWFERFIIAFRQAIFNSANLALLFNLDHA-LI 494
XP_002004300        454 QDETYARIGELWFERFITALRQSIFNNANLVLLFQLDHIlIA 495
WGS:AAQB:GK21484-PA 453 RDHRFARYAELRFEQFIEAFRKVIFQNANLALLFHLDEE-LL 493
WGS:AAPP:GF12186-PA 452 RDPQFARFAELRFEHFIVAFRSAVFNSANLALLFKLDDE-LI 492
ESS35660            388 STLRGAKEFAQHPDRLLSDIRQQIRRQPALIHLLNLDRLyPR 429
EAY02324            436 VDQVKRNKFLADPQYWHDEAMKVAQKKPELVPLLGLQNE-FP 476
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