4KDC


Conserved Protein Domain Family
UbiG
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TIGR01983: UbiG 
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ubiquinone biosynthesis O-methyltransferase
This model represents an O-methyltransferase believed to act at two points in the ubiquinone biosynthetic pathway in bacteria (UbiG) and fungi (COQ3). A separate methylase (MenG/UbiE) catalyzes the single C-methylation step. The most commonly used names for genes in this family do not indicate whether this gene is an O-methyl, or C-methyl transferase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]
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Statistics
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PSSM-Id: 273910
Aligned: 16 rows
Threshold Bit Score: 324.248
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4KDC_A               22 EIAKFEAVASRWWDLEGEFKPLHRINPLRLGYIAERAGG---------------------------LF------------ 62  Escheric...
Q9NZJ6               96 EVKTFLALAHKWWDEQGVYAPLHSMNDLRVPFIRDNLLKtipnh-----------------qpgkpLL------------ 146 human
CAB16512             32 EVEKFGDLSAEWADELGPFHALHSLNRIRVPWIVDNVRKsdqk------------------------------------- 74  Caenorha...
O49354               80 ELAKFSAIADTWWHSEGPFKPLHQMNPTRLAFIRSTLCRhfskdp----------------ssakpFE------------ 131 thale cress
Q98G87               13 EVERFSALAAEWWNPNGKFRPLHKFNPVRLSYIRDQIAArfgrdp----------------raarpFE------------ 64  Mesorhiz...
BAC45479             19 EIAKFSKLSAEWWDPKGKMAPLHRINPLRLGYIRDAACRkfernv----------------rslncLG------------ 70  Bradyrhi...
lhbprmlnih:CBU_0350  12 ELAKFSDLAQDWWNPAGKMKPLHLINPVRLKYIEQQIT----------------------------LK------------ 51  Coxiella...
Q9ZCT9                8 ELEKFEKISHNWWNKNGEFGILHRINHIRIEYIIEKIKSny-----------------------ndIS------------ 52  Ricketts...
P27680               40 EVKHFQELAPTWWDTDGSQRILHKMNLTRLDFVQRTVRNqvkiqnpeifvpgfnykeflpeyvcdnIQremqesietnld 119 Saccharo...
WP_010962529        161 EISKFAKMAGQWWDENGKFKPLHIMNPVRVSYIIEKIKElkk----------------------cnLK------------ 206 Wolbachi...

4KDC_A               63 ---GKKVLDVGCGGGILAESMAREGAT--VTGLDMGFEPLQVAKLHALESGIq-------VDYVQETVEEHAAKh--aGQ 128 Escheric...
Q9NZJ6              147 ---GMKILDVGCGGGLLTEPLGRLGAS--VIGIDPVDENIKTAQCHKSFDPVld----krIEYRVCSLEEIVEEt--aET 215 human
CAB16512             75 --appRLVDVGSGGGLLSIPLARSGFD--VTGIDATKQAVEAANQSLTAKPLqiagiskrLRFEHTSVEDFCQKphnkSA 150 Caenorha...
O49354              132 ---GLKFIDIGCGGGLLSEPLARMGAT--VTGVDAVDKNVKIARLHADMDPVts-----tIEYLCTTAEKLADEg--rK- 198 thale cress
Q98G87               65 ---GLRILDIGCGGGLLCEPMARLGAE--VVGADASETNIEVAKLHAAEGNVi-------VDYRATTAEDLADAg--eT- 129 Mesorhiz...
BAC45479             71 ---GLRVLDIGCGAGLLCEPLSRLGAQ--VIGVDPSQSNIAAAKLHADKSHLa-------IDYRCTTVEEIDPRe---R- 134 Bradyrhi...
lhbprmlnih:CBU_0350  52 ---GKHVLDVGCGGGLLSEALAKHGAI--VTGVDMSESLIDVAKNHAEQQQLn-------INYQCQDIEILTKDa---QR 116 Coxiella...
Q9ZCT9               53 ---KLQILDVGCGGGLIAAPLALQGFN--VTAIDALKSNVETATIYAQKNGLk-------INYLQATIEELENDk---L- 116 Ricketts...
P27680              120 krpEVSVLDVGCGGGILSESLARLKWVknVQGIDLTRDCIMVAKEHAKKDPMle----gkINYECKALEDV--T----GQ 189 Saccharo...
WP_010962529        207 ---ELSLLDVGCGGGILSESMARVGIN--VVGIDVCEENIKVAHSHAKKVGLn-------IEYIHTSIEELSNDk----k 270 Wolbachi...

4KDC_A              129 YDVVTCMEMLEHVPDPQSVVRACAQLVKPG-GDVFFSTLNRNGKSWLMAVVGAEYILRMVPKGTHDVKKFIKPAELLGWV 207 Escheric...
Q9NZJ6              216 FDAVVASEVVEHVIDLETFLQCCCQVLKPG-GSLFITTINKTQLSYALGIVFSEQIASIVPKGTHTWEKFVSPETLESIL 294 human
CAB16512            151 YDAVVASEIVEHVADLPGFIGCLAELARPG-APLFITTINRTWLSKLAAIWLAENVLKIVPPGVHDWEKFITPAELTSHL 229 Caenorha...
O49354              199 FDAVLSLEVIEHVANPAEFCKSLSALTIPN-GATVLSTINRTMRAYASTIVGAEYILRWLPKGTHQWSSFVTPEEMSMIL 277 thale cress
Q98G87              130 FDVILNMEVVEHVADIDLFVAKCGQMVRPG-GIMFVATINRTLKALGLAIIGAEYVLRWLPRGTHQFGKLVRPEELEKAL 208 Mesorhiz...
BAC45479            135 FDIVLAMEVVEHVVDVGVFLKRCAAMLKPN-GLMVVSTLNRNWKSFALAIVGAEYVLRWLPRGTHEWNKFVTPDELTKYL 213 Bradyrhi...
lhbprmlnih:CBU_0350 117 FDIITCMELLEHVPDPQRMIKNCAALIKPG-GKLFFSTINRNFKAYLYTIVGAEYVFNLLPKGTHDYAQFIRPSELTQWA 195 Coxiella...
Q9ZCT9              117 YDVVICLEVIEHVANIQQFILNLVQHIKPN-GIAIISTMNRTKKAYLFGIIVAEYILGWVPKNTHDYSKFVKPSEIYEIL 195 Ricketts...
P27680              190 FDIITCMEMLEHVDMPSEILRHCWSRLNPEkGILFLSTINRDLISWFTTIFMGENVLKIVPKGTHHLSKYINSKEILAWF 269 Saccharo...
WP_010962529        271 YDVVLLMEVVEHVDNLELFMKKAIELLKPE-GLIFISTINRTIKSFCLAIIGAEYILNWLPKGTHNWNKFLKPSEIANHL 349 Wolbachi...

4KDC_A              208 D---QTSLKERHITGLHYNPITNTFKLGPGVDVNYM 240 Escherichia coli K-12
Q9NZJ6              295 E---SNGLSVQTVVGMLYNPFSGYWHWSENTSLNYA 327 human
CAB16512            230 E---KAGCRVTAVHGLMFHPVGNHWTWIESTQCNYG 262 Caenorhabditis elegans
O49354              278 Q---RASVDVKEIAGFVYNPITGRWLLSDDISVNYI 310 thale cress
Q98G87              209 G---GASLTIIDRTGVTYNPLADRWARSKDMDVNYM 241 Mesorhizobium loti MAFF303099
BAC45479            214 L---DNRLVITEQTGVVYSPFADKWTLSSDMDVNYM 246 Bradyrhizobium diazoefficiens USDA 110
lhbprmlnih:CBU_0350 196 E---SGGLRLLDITGIHYHPLKNEFDLSRDVSVNYL 228 Coxiella burnetii RSA 493
Q9ZCT9              196 T---DTNIEIKELKGLVFNLAKNEWKLSNDIDVNYF 228 Rickettsia prowazekii str. Madrid E
P27680              270 NdnySGQFRLLDLKGTMYLPYQGWVEHDCSDVGNYF 305 Saccharomyces cerevisiae S288c
WP_010962529        350 R---ENNVTLQNMAGMEYNVIKREWNLTKGVDVNYI 382 Wolbachia endosymbiont of Drosophila melanogaster
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