6RO4,1D4U,6J44,1XPA


Conserved Protein Domain Family
DBD_XPA
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cd21076: DBD_XPA 
DNA-binding domain found in DNA repair protein complementing XP-A cells (XPA) and similar proteins
XPA, also known as xeroderma pigmentosum group A-complementing protein (XPAC), is involved in DNA excision repair. It initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region.
Links
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Statistics
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PSSM-Id: 410962
Aligned: 29 rows
Threshold Bit Score: 162.81
Created: 12-Feb-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Zn binding siteDNA binding
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:6RO4; Homo sapiens repair factor XPA binds Zn2+ ion.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #  #                 #  #                                                   
6RO4_G       101 DYVICEECGKEFMDSYLMNHFDlpTCDNCRDaDDKHKLITKTEAKQEYLLKDCDLEKREPPLKFIVKKNPHHsQWGDMKL 180 human
P28518       122 QYEECLECGDMFADSYLFNNFGhsVCDKCRDkDERYALITRTEAKAEYLLKDCDFDKREPKLRYISRKNPHNvRWGEMKL 201 fruit fly
XP_002601308  86 DRVACELCNSEISDSFLYNSFDvpVCDGCKDmEEKHKLITKTEAKQQFLLKDCDFDQRDPPLRCIIKKNPHNqRWGDMKL 165 Florida lancelet
GAA48573     121 DKPVCDQCNRTFDDSFLRKHFDvdVCDRCRDpKGLHTMITKSTAKDRYLVNDVDLDVREPKLRFVLKRNPHNsVWGDMRL 200 Clonorchis sine...
CDS27972     152 EKPVCDECSRTFDDSFLLSNFDcqVCDACRDyKGIHSLITRTSAKDRYLLSDVDLDVREPPLRRIFKKNPRNsTWGDMQL 231 Hymenolepis mic...
XP_009028879 104 EKPICEDCKSTFSDSFLFDHFLksVCDSCRDkEEKHRLITKTEAKERYLLKDCDFEIREPVLKYVLKKNPNYkKFGEMKL 183 Helobdella robusta
XP_011662567 110 DPLRCQECGRGFQDSYLSKHFElsVCDECRDnDEKHVLITKTDARNEFLLKDEDFEKREPPLKFITRKNPHNvRWGEMKL 189 purple sea urchin
NP_001296580  83 SQDLCRECHAKFSDSFMLKNFNlnVCDGCRD-KDKHKLITKTDAKQKYCLKDCDFDVREPPLKFILKKNPHNdRWGDMKL 161 Hydra vulgaris
XP_013403478  91 DLLICNECSKEFMDSFLYSHFEefVCDKCRDnEEKHSLITKTDAKNKYLLKDADFDRREPSLRFIVKKNPHNnRWGEMKL 170 Lingula anatina
CRL04855      91 AYQKCVECDEEFADSYLYKNFGfsCCDKCKN-EENSMLITKTTARDEFLLKDCDFDRREPPLKFISRKNPHKsTWAEMKL 169 Clunio marinus

Feature 1                                   
6RO4_G       181 YLKLQIVKRSLEVWGSQEALEEAKEVR 207 human
P28518       202 YLHLQIHQRALEVWGSEEELVRQHEAR 228 fruit fly
XP_002601308 166 FLLYQVVKRAHEIWGDEDGLEQERERR 192 Florida lancelet
GAA48573     201 YLEAQVAQRSLEIWGSEDKLEAERERR 227 Clonorchis sinensis
CDS27972     232 FLEAQVAARSLEVWGSEENVEAERSNR 258 Hymenolepis microstoma
XP_009028879 184 YLECQVAERAFEVWGSDEKLEEEIERR 210 Helobdella robusta
XP_011662567 190 FLRLHVEERALEVWGDPETMEEAREQR 216 purple sea urchin
NP_001296580 162 FLEDQVRNRAIEVWGSEDGIEEQKELR 188 Hydra vulgaris
XP_013403478 171 YLESQVYKRAMEVWGSEEKIEEAQERR 197 Lingula anatina
CRL04855     170 YLRSQVEARALEVFESLEKIAQEKQIR 196 Clunio marinus

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